Uncertainty in the translation of preclinical experiments to clinical trials. Why do most phase III clinical trials fail? (Q33828102)

29 July 2017

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title

Uncertainty in the translation of preclinical experiments to clinical trials. Why do most phase III clinical trials fail? (English)

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29 July 2017

phase III clinical trial

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author name string

Pedro R Lowenstein

series ordinal

1

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PubMed ID

19860651

29 July 2017

Maria G Castro

series ordinal

2

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PubMed ID

19860651

29 July 2017

language of work or name

English

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publication date

1 October 2009

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29 July 2017

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29 July 2017

9

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29 July 2017

5

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29 July 2017

368-374

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Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States.

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Antiglioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy: humoral and cellular immunity lead to tumor regression

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4 July 2018

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4 July 2018

1 reference

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Multiparameter computational modeling of tumor invasion

4 July 2018

1 reference

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Quantitative metrics of net proliferation and invasion link biological aggressiveness assessed by MRI with hypoxia assessed by FMISO-PET in newly diagnosed glioblastomas

4 July 2018

1 reference

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Interpreting trial results in light of conflicting evidence: a Bayesian analysis of adjuvant chemotherapy for non-small-cell lung cancer

4 July 2018

1 reference

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De novo induction of genetically engineered brain tumors in mice using plasmid DNA

4 July 2018

1 reference

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HMGB1 mediates endogenous TLR2 activation and brain tumor regression

4 July 2018

1 reference

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Development of a novel mouse glioma model using lentiviral vectors

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Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft model

4 July 2018

1 reference

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Temozolomide for High Grade Glioma

4 July 2018

1 reference

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Clinical trials in gene therapy: ethics of informed consent and the future of experimental medicine.

4 July 2018

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What is the translational efficacy of chemotherapeutic drug research in neuro-oncology? A systematic review and meta-analysis of the efficacy of BCNU and CCNU in animal models of glioma.

4 July 2018

1 reference

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Multiscale modelling and nonlinear simulation of vascular tumour growth.

4 July 2018

1 reference

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Malignant gliomas in adults

4 July 2018

1 reference

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Running an ethical trial 60 years after the Nuremberg Code

4 July 2018

1 reference

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The effectiveness and cost-effectiveness of carmustine implants and temozolomide for the treatment of newly diagnosed high-grade glioma: a systematic review and economic evaluation

4 July 2018

1 reference

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Effect size, confidence interval and statistical significance: a practical guide for biologists

4 July 2018

1 reference

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Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression.

4 July 2018

1 reference

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Gene therapy clinical trials worldwide to 2007--an update.

4 July 2018

1 reference

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Why most published research findings are false: problems in the analysis

4 July 2018

1 reference

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The evolution of mathematical modeling of glioma proliferation and invasion.

4 July 2018

1 reference

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Comparison of treatment effects between animal experiments and clinical trials: systematic review

4 July 2018

1 reference

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Size of treatment effects and their importance to clinical research and practice

4 July 2018

1 reference

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Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864134

Why most published research findings are false

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864134

Dose-dependent effects of platelet-derived growth factor-B on glial tumorigenesis

4 July 2018

1 reference

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Systematic reviews of animal experiments

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864134

Complexity and robustness

4 July 2018

1 reference

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The origins of informed consent: the International Scientific Commission on Medical War Crimes, and the Nuremburg code

4 July 2018

1 reference

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Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials

4 July 2018

1 reference

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Toward evidence-based medical statistics. 1: The P value fallacy

4 July 2018

1 reference

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Toward evidence-based medical statistics. 2: The Bayes factor

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864134

Endogenous expression of transforming growth factor beta1 inhibits growth and tumorigenicity and enhances Fas-mediated apoptosis in a murine high-grade glioma model.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864134

Building a Bayesian bridge from evidence to guidelines

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864134

Bayesian classification of clinical practice guidelines

29 October 2018

1 reference

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Explorations in statistics: confidence intervals.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864134

Explorations in statistics: hypothesis tests and P values.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864134

A call for physiopathological ethics

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864134

The ethics of human gene transfer.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864134

Does a statistically significant survival benefit of erlotinib plus gemcitabine for advanced pancreatic cancer translate into clinical significance and value?

29 October 2018

1 reference

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Glial progenitors in adult white matter are driven to form malignant gliomas by platelet-derived growth factor-expressing retroviruses.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864134

Biopsy versus resection for malignant glioma.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864134

The Nuremberg Medical Trial: have we learned the lessons?

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2864134

10.2174/156652309789753392

29 October 2018

Identifiers

DOI

1 reference

29 July 2017

1 reference

29 July 2017

1 reference

PubMed ID

19860651