Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft model (Q37467299)

20 August 2017

Evaluation of MGMT promoter methylation status and correlation with temozolomide response in orthotopic glioblastoma xenograft model (English)

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20 August 2017

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8

Caterina Giannini

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20 August 2017

Gaspar J Kitange

1

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20 August 2017

Brett L Carlson

2

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20 August 2017

Ann C Mladek

3

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20 August 2017

Paul A Decker

4

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20 August 2017

Mark A Schroeder

5

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20 August 2017

Wenting Wu

6

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20 August 2017

Patrick T Grogan

7

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20 August 2017

Karla V Ballman

9

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20 August 2017

Jan C Buckner

10

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20 August 2017

C David James

11

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20 August 2017

Jann N Sarkaria

12

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20 August 2017

15 November 2008

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Journal of Neuro-Oncology

20 August 2017

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20 August 2017

92

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20 August 2017

1

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20 August 2017

23-31

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https://scigraph.springernature.com/pub.10.1007/s11060-008-9737-8

20 August 2017

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cites work

Validation of real-time methylation-specific PCR to determine O6-methylguanine-DNA methyltransferase gene promoter methylation in glioma.

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Targeted modulation of MGMT: clinical implications

23 August 2017

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Methyl-CpG-binding proteins in cancer: blaming the DNA methylation messenger

23 August 2017

1 reference

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MGMT gene silencing and benefit from temozolomide in glioblastoma

23 August 2017

1 reference

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Sequence-specific transcriptional repression by an MBD2-interacting zinc finger protein MIZF

23 August 2017

1 reference

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The affinity of different MBD proteins for a specific methylated locus depends on their intrinsic binding properties

23 August 2017

1 reference

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CpG methylation of MGMT and hMLH1 promoter in hepatocellular carcinoma associated with hepatitis viral infection.

23 August 2017

1 reference

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Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide

23 August 2017

1 reference

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Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents

23 August 2017

1 reference

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23 August 2017

1 reference

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CpG methylation within the 5' regulatory region of the BRCA1 gene is tumor specific and includes a putative CREB binding site

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790867

Epigenetic silencing of TCEAL7 (Bex4) in ovarian cancer.

23 August 2017

1 reference

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Epigenetic regulation of O6-methylguanine-DNA methyltransferase gene expression by histone acetylation and methyl-CpG binding proteins.

14 September 2017

1 reference

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Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide

14 September 2017

1 reference

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Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR

14 September 2017

1 reference

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Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790867

Heterogeneous methylation of the O(6)-methylguanine-DNA methyltransferase promoter in immortalized IMR90 cell lines

14 September 2017

1 reference

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Increased sensitivity of transforming growth factor (TGF) beta 1 null cells to alkylating agents reveals a novel link between TGFbeta signaling and O(6)-methylguanine methyltransferase promoter hypermethylation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790867

Activity of temozolomide in the treatment of central nervous system tumor xenografts

28 September 2017

1 reference

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Localization of methylation sites in the human O6-methylguanine-DNA methyltransferase promoter: correlation with gene suppression

28 September 2017

1 reference

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Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme

28 September 2017

1 reference

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Identification of molecular characteristics correlated with glioblastoma sensitivity to EGFR kinase inhibition through use of an intracranial xenograft test panel

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790867

Use of an orthotopic xenograft model for assessing the effect of epidermal growth factor receptor amplification on glioblastoma radiation response.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790867

CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790867

Distinct responses of xenografted gliomas to different alkylating agents are related to histology and genetic alterations

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790867

Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790867

DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790867

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2790867

A specific CpG methylation pattern of the MGMT promoter region associated with reduced MGMT expression in primary colorectal cancers

2 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19011762

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

MGMT immunohistochemical expression and promoter methylation in human glioblastoma

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19011762

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S11060-008-9737-8

1 reference

20 August 2017

1 reference

20 August 2017

PubMed publication ID

19011762

1 reference