Mechanisms of switching on p53: a role for covalent modification? (Q33807813)

29 July 2017

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title

Mechanisms of switching on p53: a role for covalent modification? (English)

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29 July 2017

Meek DW

1

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PubMed ID

10618706

29 July 2017

language of work or name

English

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publication date

1 December 1999

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29 July 2017

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29 July 2017

18

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29 July 2017

7666-7675

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29 July 2017

53

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1202951

29 July 2017

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cites work

Conformation-dependent phosphorylation of p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Protein kinases and the response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Reciprocal interference between the sequence-specific core and nonspecific C-terminal DNA binding domains of p53: implications for regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Regulation of p53 function and stability by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Stabilization and activation of p53 are regulated independently by different phosphorylation events

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

E1A signaling to p53 involves the p19(ARF) tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

JNK targets p53 ubiquitination and degradation in nonstressed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

MEKK1/JNK signaling stabilizes and activates p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

The complexity of p53 modulation: emerging patterns from divergent signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Mutation of phosphoserine 389 affects p53 function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Regulation of the cryptic sequence-specific DNA-binding function of p53 by protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Regulation of the specific DNA binding function of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

ATM associates with and phosphorylates p53: mapping the region of interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Multisite phosphorylation and the integration of stress signals at p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Protein interactions at the carboxyl terminus of p53 result in the induction of its in vitro transactivation potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Mutations in the p53 and SCID genes cooperate in tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

DNA damage induces phosphorylation of the amino terminus of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

A role for ATR in the DNA damage-induced phosphorylation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

A functional p53-responsive intronic promoter is contained within the human mdm2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

p19ARF links the tumour suppressor p53 to Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

Phosphorylation of p53 protein in response to ionizing radiation occurs at multiple sites in both normal and DNA-PK deficient cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

7 January 2021

mdm2 expression is induced by wild type p53 activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

7 January 2021

DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

7 January 2021

Comparative study of the p53-mdm2 and p53-MDMX interfaces

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

7 January 2021

Genomic instability and apoptosis are frequent in p53 deficient young mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

7 January 2021

Phosphorylation of p53 serine 15 increases interaction with CBP

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

7 January 2021

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

7 January 2021

The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

7 January 2021

Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

7 January 2021

Sequence-specific DNA binding by p53: identification of target sites and lack of binding to p53 - MDM2 complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1202951

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1202951

1 reference

PubMed ID

10618706

Dimensions Publication ID

29 July 2017

0 references

1 reference

PubMed ID

10618706