The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation. (Q33770369)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15870293%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

title

The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation (English)

1 reference

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11 January 2020

8

1 reference

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11 January 2020

11

Sarah Spiegel

1 reference

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11 January 2020

author name string

Sravan K Goparaju

1

1 reference

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11 January 2020

Puneet S Jolly

2

1 reference

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11 January 2020

Kenneth R Watterson

3

1 reference

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11 January 2020

Meryem Bektas

4

1 reference

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11 January 2020

Sergio Alvarez

5

1 reference

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11 January 2020

Sukumar Sarkar

6

1 reference

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11 January 2020

Lin Mel

7

1 reference

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11 January 2020

Jerold Chun

9

1 reference

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11 January 2020

Sheldon Milstien

10

1 reference

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11 January 2020

language of work or name

English

0 references

publication date

1 May 2005

1 reference

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Molecular and Cellular Biology

11 January 2020

published in

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11 January 2020

volume

25

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issue

10

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11 January 2020

page(s)

4237-4249

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Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells

11 January 2020

cites work

1 reference

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Lysophospholipid G protein-coupled receptors

4 July 2018

1 reference

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Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.

4 July 2018

1 reference

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Rho and Rac take center stage

4 July 2018

1 reference

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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

4 July 2018

1 reference

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Blood lipid mediator sphingosine 1-phosphate potently stimulates platelet-derived growth factor-A and -B chain expression through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5

4 July 2018

1 reference

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S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR).

4 July 2018

1 reference

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Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis

4 July 2018

1 reference

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Sphingosine-1-phosphate: an enigmatic signalling lipid

4 July 2018

1 reference

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Biology of the p21-activated kinases

4 July 2018

1 reference

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Cellular motility driven by assembly and disassembly of actin filaments

4 July 2018

1 reference

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Inhibitory and stimulatory regulation of Rac and cell motility by the G12/13-Rho and Gi pathways integrated downstream of a single G protein-coupled sphingosine-1-phosphate receptor isoform

4 July 2018

1 reference

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Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS).

4 July 2018

1 reference

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Akt activation induced by lysophosphatidic acid and sphingosine-1-phosphate requires both mitogen-activated protein kinase kinase and p38 mitogen-activated protein kinase and is cell-line specific

4 July 2018

1 reference

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Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3.

4 July 2018

1 reference

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Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

4 July 2018

1 reference

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EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration

4 July 2018

1 reference

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Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis

4 July 2018

1 reference

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Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement

4 July 2018

1 reference

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Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3

4 July 2018

1 reference

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

4 July 2018

1 reference

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Mammalian MAP kinase signalling cascades

4 July 2018

1 reference

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Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells

4 July 2018

1 reference

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Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility

4 July 2018

1 reference

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Paxillin and focal adhesion signalling

4 July 2018

1 reference

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An oncogenic role of sphingosine kinase

4 July 2018

1 reference

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Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3

4 July 2018

1 reference

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Sphingosine 1-phosphate released from platelets during clotting accounts for the potent endothelial cell chemotactic activity of blood serum and provides a novel link between hemostasis and angiogenesis.

4 July 2018

1 reference

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Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

4 July 2018

1 reference

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Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy

4 July 2018

1 reference

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Antiproliferative properties of sphingosine 1-phosphate in human hepatic myofibroblasts. A cyclooxygenase-2 mediated pathway

4 July 2018

1 reference

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Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

4 July 2018

1 reference

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Induction of endothelial cell chemotaxis by sphingosine 1-phosphate and stabilization of endothelial monolayer barrier function by lysophosphatidic acid, potential mediators of hematopoietic angiogenesis

4 July 2018

1 reference

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Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis

4 July 2018

1 reference

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Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCgamma

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

N,N-Dimethylsphingosine is a potent competitive inhibitor of sphingosine kinase but not of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Molecular cloning and functional characterization of murine sphingosine kinase

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Pericyte loss and microaneurysm formation in PDGF-B-deficient mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Abnormal kidney development and hematological disorders in PDGF beta-receptor mutant mice.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Deletion of the PDGFR-beta gene affects key fibroblast functions important for wound healing.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Gab1 contributes to cytoskeletal reorganization and chemotaxis in response to platelet-derived growth factor

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Sphingosine kinase transmits estrogen signaling in human breast cancer cells.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Sphingosine 1-phosphate is a novel inhibitor of T-cell proliferation

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Sphingosine 1-phosphate and platelet-derived growth factor (PDGF) act via PDGF beta receptor-sphingosine 1-phosphate receptor complexes in airway smooth muscle cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphate

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Sphingosine-1-phosphate, a platelet-derived lysophospholipid mediator, negatively regulates cellular Rac activity and cell migration in vascular smooth muscle cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1087716

Purification and characterization of rat kidney sphingosine kinase

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15870293

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Platelet-derived growth factor activates p38 mitogen-activated protein kinase through a Ras-dependent pathway that is important for actin reorganization and cell migration

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15870293

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.25.10.4237-4249.2005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15870293%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15870293%20AND%20SRC:MED&resulttype=core&format=json

11 January 2020

1 reference