Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53. (Q40584948)

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24 November 2019

title

Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53 (English)

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24 November 2019

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9

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8

Yusuf A Hannun

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24 November 2019

author name string

Tarek A Taha

1

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Walid Osta

2

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24 November 2019

Lina Kozhaya

3

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Jacek Bielawski

4

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Korey R Johnson

5

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William E Gillanders

6

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Ghassan S Dbaibo

7

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language of work or name

English

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publication date

26 February 2004

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Journal of Biological Chemistry

24 November 2019

published in

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volume

279

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issue

19

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page(s)

20546-20554

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Functions of ceramide in coordinating cellular responses to stress

24 November 2019

cites work

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Regulation of protein kinase C by sphingosine and lysosphingolipids

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Ceramide: role in growth inhibitory cascades

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Sphingosine-1-phosphate: an enigmatic signalling lipid

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Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

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Shared pathways: death receptors and cytotoxic drugs in cancer therapy

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Killing tumours by ceramide-induced apoptosis: a critique of available drugs

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p53-dependent ceramide response to genotoxic stress

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Bcl-2 interrupts the ceramide-mediated pathway of cell death.

21 January 2018

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The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha

21 January 2018

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Actinomycin and DNA transcription

21 January 2018

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Apoptosis and cancer drug targeting

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Inhibition of caspase-3-mediated poly(ADP-ribose) polymerase (PARP) apoptotic cleavage by human PARP autoantibodies and effect on cells undergoing apoptosis.

21 January 2018

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Apoptotic threshold is lowered by p53 transactivation of caspase-6

21 January 2018

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Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor

21 January 2018

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Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage

21 January 2018

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Sphingosine kinase, sphingosine-1-phosphate, and apoptosis

21 January 2018

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PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)

21 January 2018

1 reference

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Cytokine response modifier A (CrmA) inhibits ceramide formation in response to tumor necrosis factor (TNF)-alpha: CrmA and Bcl-2 target distinct components in the apoptotic pathway

21 January 2018

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The promise and obstacle of p53 as a cancer therapeutic agent

21 January 2018

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Lysosomal destabilization in p53-induced apoptosis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M401259200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14988393%20AND%20SRC:MED&resulttype=core&format=json

24 November 2019

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