Antiandrogen flutamide protects male mice from androgen-dependent toxicity in three models of spinal bulbar muscular atrophy. (Q33765455)

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14 March 2020

title

Antiandrogen flutamide protects male mice from androgen-dependent toxicity in three models of spinal bulbar muscular atrophy (English)

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3

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Hiroaki Adachi

5

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Marc Breedlove

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Cynthia L Jordan

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Andrew P Lieberman

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4

Masahisa Katsuno

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Sandra M Troxell-Smith

2

object named as

Sandra M Troxell-Smith

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14 March 2020

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Kayla J Renier

1

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Jason P Chua

7

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Hong Sun Kim

8

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Gen Sobue

6

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language of work or name

English

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publication date

17 April 2014

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volume

155

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issue

7

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page(s)

2624-2634

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Androgen receptors in muscle fibers induce rapid loss of force but not mass: implications for spinal bulbar muscular atrophy.

14 March 2020

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Native functions of the androgen receptor are essential to pathogenesis in a Drosophila model of spinobulbar muscular atrophy

22 June 2018

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Phase 2 trial of leuprorelin in patients with spinal and bulbar muscular atrophy

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Overexpression of wild-type androgen receptor in muscle recapitulates polyglutamine disease.

22 June 2018

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Androgen-dependent pathology demonstrates myopathic contribution to the Kennedy disease phenotype in a mouse knock-in model

22 June 2018

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Abnormalities of germ cell maturation and sertoli cell cytoskeleton in androgen receptor 113 CAG knock-in mice reveal toxic effects of the mutant protein

22 June 2018

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The corepressors silencing mediator of retinoid and thyroid hormone receptor and nuclear receptor corepressor are involved in agonist- and antagonist-regulated transcription by androgen receptor

22 June 2018

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22 June 2018

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22 June 2018

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alpha-Synuclein locus triplication causes Parkinson's disease

22 June 2018

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Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT.

22 June 2018

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Formation of the androgen receptor transcription complex

22 June 2018

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Androgen-induced NH2- and COOH-terminal Interaction Inhibits p160 coactivator recruitment by activation function 2.

22 June 2018

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22 June 2018

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p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation

22 June 2018

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Distinguishing androgen receptor agonists and antagonists: distinct mechanisms of activation by medroxyprogesterone acetate and dihydrotestosterone

22 June 2018

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22 June 2018

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Evidence for an anti-parallel orientation of the ligand-activated human androgen receptor dimer

22 June 2018

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Steroid requirement for androgen receptor dimerization and DNA binding. Modulation by intramolecular interactions between the NH2-terminal and steroid-binding domains.

22 June 2018

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A biological profile of a nonsteroidal antiandrogen, SCH 13521 (4'-nitro-3'trifluoromethylisobutyranilide).

22 June 2018

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Progressive proximal spinal and bulbar muscular atrophy of late onset. A sex-linked recessive trait

22 June 2018

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Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues.

22 June 2018

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Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

22 June 2018

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22 June 2018

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Effects of a non-steroidal antiandrogen on sexual behavior and pituitary-gonadal function in the male rat.

22 June 2018

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Mice with the testicular feminization mutation demonstrate a role for androgen receptors in the regulation of anxiety-related behaviors and the hypothalamic-pituitary-adrenal axis.

22 June 2018

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Soluble androgen receptor oligomers underlie pathology in a mouse model of spinobulbar muscular atrophy

30 October 2018

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Administration of testosterone results in reversible deterioration in Kennedy's disease.

30 October 2018

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Human expanded polyglutamine androgen receptor mutants in neurodegeneration as a novel ligand target

30 October 2018

1 reference

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Flutamide administration at 500 mg daily has similar effects on serum testosterone to 750 mg daily

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060177

Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4060177

Androgen receptor immunoreactivity in skeletal muscle: enrichment at the neuromuscular junction

30 October 2018

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Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy

30 October 2018

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Ligand promotes intranuclear inclusions in a novel cell model of spinal and bulbar muscular atrophy

30 October 2018

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Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila.

30 October 2018

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Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

30 October 2018

1 reference

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Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor

30 October 2018

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Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

30 October 2018

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Endocrinological and histological changes induced by flutamide treatment on the hypothalamo-hypophyseal testicular axis of the adult male rat and their incidences on fertility

30 October 2018

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Androgen receptor gene (CAG)n repeat analysis in the differential diagnosis between Kennedy disease and other motoneuron disorders

30 October 2018

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SIRT1 modulates aggregation and toxicity through deacetylation of the androgen receptor in cell models of SBMA.

30 October 2018

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12 December 2020

X-linked bulbar and spinal muscular atrophy, or Kennedy disease: clinical, neurophysiological, neuropathological, neuropsychological and molecular study of a large family

1 reference

12 December 2020

Metabolism and hepatic toxicity of flutamide in cytochrome P450 1A2 knockout SV129 mice

1 reference

12 December 2020

Anabolic responsiveness of skeletal muscles correlates with androgen receptor protein but not mRNA

1 reference

12 December 2020

Androgen receptor expression in the levator ani muscle of male mice

1 reference

12 December 2020

Phenotypic manifestations associated with CAG-repeat expansion in the androgen receptor gene in male patients and heterozygous females: a clinical and molecular study of 30 families

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12 December 2020

Expression of X-linked bulbospinal muscular atrophy (Kennedy disease) in two homozygous women

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12 December 2020

Identifiers

DOI

10.1210/EN.2013-1756

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24742193%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24742193%20AND%20SRC:MED&resulttype=core&format=json

14 March 2020

PubMed publication ID

24742193

1 reference