Interactions with DCAF1 and DDB1 in the CRL4 E3 ubiquitin ligase are required for Vpr-mediated G2 arrest (Q33759415)

24912982

29 July 2017

title

Interactions with DCAF1 and DDB1 in the CRL4 E3 ubiquitin ligase are required for Vpr-mediated G2 arrest (English)

1 reference

29 July 2017

2

1 reference

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7 June 2020

author name string

Yoshiyuki Hakata

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24912982%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Nathaniel R Landau

series ordinal

3

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7 June 2020

publication date

9 June 2014

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29 July 2017

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7 June 2020

volume

11

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7 June 2020

page(s)

108

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describes a project that uses

7 June 2020

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4058697/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1186/1743-422x-11-108

0 references

cites work

Premature activation of the SLX4 complex by Vpr promotes G2/M arrest and escape from innate immune sensing

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The HIV1 protein Vpr acts to enhance constitutive DCAF1-dependent UNG2 turnover

21 June 2018

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HIV-1 Vpr loads uracil DNA glycosylase-2 onto DCAF1, a substrate recognition subunit of a cullin 4A-ring E3 ubiquitin ligase for proteasome-dependent degradation

21 June 2018

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Formation of mobile chromatin-associated nuclear foci containing HIV-1 Vpr and VPRBP is critical for the induction of G2 cell cycle arrest

21 June 2018

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HIV-1 Vpr up-regulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing

21 June 2018

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A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery

21 June 2018

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HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response

21 June 2018

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Assembly with the Cul4A-DDB1DCAF1 ubiquitin ligase protects HIV-1 Vpr from proteasomal degradation.

21 June 2018

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Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection

21 June 2018

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HIV-1 Vpr-mediated G2 arrest involves the DDB1-CUL4AVPRBP E3 ubiquitin ligase

21 June 2018

1 reference

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DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest

21 June 2018

1 reference

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The HIV1 protein Vpr acts to promote G2 cell cycle arrest by engaging a DDB1 and Cullin4A-containing ubiquitin ligase complex using VprBP/DCAF1 as an adaptor

21 June 2018

1 reference

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Lentiviral Vpr usurps Cul4-DDB1[VprBP] E3 ubiquitin ligase to modulate cell cycle

21 June 2018

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HIV-1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system

21 June 2018

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HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1

21 June 2018

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HIV1 Vpr arrests the cell cycle by recruiting DCAF1/VprBP, a receptor of the Cul4-DDB1 ubiquitin ligase

21 June 2018

1 reference

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DDB1 functions as a linker to recruit receptor WD40 proteins to CUL4-ROC1 ubiquitin ligases

21 June 2018

1 reference

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CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation

21 June 2018

1 reference

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Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery

21 June 2018

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21 June 2018

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A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1

21 June 2018

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21 June 2018

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21 June 2018

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Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation.

21 June 2018

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21 June 2018

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Hepatitis B Virus X Protein and Simian Virus 5 V Protein Exhibit Similar UV-DDB1 Binding Properties To Mediate Distinct Activities

21 June 2018

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21 June 2018

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Human immunodeficiency virus type 1 (HIV-1) Vpr enhances expression from unintegrated HIV-1 DNA.

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058697

Conservation and host specificity of Vpr-mediated cell cycle arrest suggest a fundamental role in primate lentivirus evolution and biology.

21 June 2018

1 reference

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Vpr-induced cell cycle arrest is conserved among primate lentiviruses.

21 June 2018

1 reference

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Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058697

Incorporation of Vpr into human immunodeficiency virus type 1 virions: requirement for the p6 region of gag and mutational analysis.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058697

Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein.

21 June 2018

1 reference

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Distinct effects in primary macrophages and lymphocytes of the human immunodeficiency virus type 1 accessory genes vpr, vpu, and nef: mutational analysis of a primary HIV-1 isolate

21 June 2018

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The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells

21 June 2018

1 reference

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Progression to AIDS in the absence of a gene for vpr or vpx.

21 June 2018

1 reference

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The human immunodeficiency virus type 1 vpr gene prevents cell proliferation during chronic infection.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058697

The human immunodeficiency virus type 1 vpr gene arrests infected T cells in the G2 + M phase of the cell cycle

21 June 2018

1 reference

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Interaction of Virion Protein Vpr of Human Immunodeficiency Virus Type 1 with Cellular Transcription Factor Sp1 and trans-Activation of Viral Long Terminal Repeat

21 June 2018

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Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes

21 June 2018

1 reference

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Simian immunodeficiency virus from African green monkeys.

21 June 2018

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Human immunodeficiency virus vpr product is a virion-associated regulatory protein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058697

Identification of HIV-1 vpr product and function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058697

HIV-1 Vpr induces TLR4/MyD88-mediated IL-6 production and reactivates viral production from latency

21 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1743-422X-11-108

Human immunodeficiency virus type 1 Vpr inhibits axonal outgrowth through induction of mitochondrial dysfunction.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1743-422X-11-108

Human immunodeficiency virus (HIV) type 1 Vpr induces differential regulation of T cell costimulatory molecules: direct effect of Vpr on T cell activation and immune function

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1743-422X-11-108

HIV-1 Vpr inhibits the maturation and activation of macrophages and dendritic cells in vitro

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058697

HIV-1 Vpr induces ATM-dependent cellular signal with enhanced homologous recombination

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24912982

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1743-422X-11-108

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24912982%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

7 June 2020

1 reference

https://scigraph.springernature.com/pub.10.1186/1743-422x-11-108

9 September 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24912982%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

24912982

1 reference