Genetic pathways in colorectal and other cancers (Q33711610)

28 July 2017

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title

Genetic pathways in colorectal and other cancers (English)

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28 July 2017

4

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28 July 2017

3

Tomlinson IP

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28 July 2017

Ilyas M

1

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28 July 2017

Straub J

series ordinal

2

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28 July 2017

publication date

1 March 1999

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European Journal of Cancer

28 July 2017

published in

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28 July 2017

volume

35

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28 July 2017

issue

3

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28 July 2017

page(s)

335-351

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The natural history of cancer

28 July 2017

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Complex interactions of new quantitative trait loci, Sluc1, Sluc2, Sluc3, and Sluc4, that influence the susceptibility to lung cancer in the mouse

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7 January 2021

Cancer. p53, guardian of the genome

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7 January 2021

p53 function and dysfunction

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7 January 2021

Mutation of the p53 gene precedes aneuploid clonal divergence in colorectal carcinoma

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7 January 2021

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability

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7 January 2021

Mutations of mitotic checkpoint genes in human cancers

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7 January 2021

Genetic instability in colorectal cancers

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7 January 2021

Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC.

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7 January 2021

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

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7 January 2021

The Li-Fraumeni cancer family syndrome

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7 January 2021

Inflammatory bowel disease and colon cancer

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7 January 2021

Colorectal cancer in ulcerative colitis. Influence of anatomical extent and age at onset on colitis-cancer interval

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https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Ulcerative colitis and Crohn's disease: a comparison of the colorectal cancer risk in extensive colitis

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https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Frequent and characteristic K-ras activation in aberrant crypt foci of colon. Is there preference among K-ras mutants for malignant progression?

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https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Phenotypic and genotypic characteristics of aberrant crypt foci in human colorectal mucosa

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7 January 2021

Screening for colorectal cancer

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7 January 2021

Importance of adenomas 5 mm or less in diameter that are detected by sigmoidoscopy

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7 January 2021

Long-term risk of colorectal cancer after excision of rectosigmoid adenomas.

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7 January 2021

Growth of colorectal polyps: redetection and evaluation of unresected polyps for a period of three years

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7 January 2021

The evolution of cancer of the colon and rectum

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7 January 2021

A genetic model for colorectal tumorigenesis

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7 January 2021

Localization of the gene for familial adenomatous polyposis on chromosome 5.

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7 January 2021

Chromosome 5 allele loss in human colorectal carcinomas.

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7 January 2021

Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas

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7 January 2021

The role of the adenomatous polyposis coli (APC) gene in human cancers.

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7 January 2021

APC mutations occur early during colorectal tumorigenesis

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7 January 2021

Identification and characterization of the familial adenomatous polyposis coli gene

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7 January 2021

Variable phenotype of familial adenomatous polyposis in pedigrees with 3' mutation in the APC gene

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7 January 2021

Alleles of the APC gene: an attenuated form of familial polyposis.

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7 January 2021

Association of the APC gene product with beta-catenin

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7 January 2021

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein

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7 January 2021

Beta-catenin mutations in cell lines established from human colorectal cancers

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7 January 2021

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

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7 January 2021

Apoptosis and APC in colorectal tumorigenesis

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7 January 2021

Identification of c-MYC as a target of the APC pathway

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7 January 2021

The interactions of APC, E-cadherin and beta-catenin in tumour development and progression

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7 January 2021

Mutation and cancer: statistical study of retinoblastoma

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7 January 2021

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

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7 January 2021

A resistant genetic background leading to incomplete penetrance of intestinal neoplasia and reduced loss of heterozygosity in ApcMin/+ mice

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7 January 2021

Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis

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7 January 2021

The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history.

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7 January 2021

The 5-methylcytosine content of DNA from human tumors

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7 January 2021

Alterations in DNA methylation may play a variety of roles in carcinogenesis

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7 January 2021

Suppression of intestinal neoplasia by DNA hypomethylation.

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7 January 2021

The ras gene family and human carcinogenesis

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7 January 2021

Ras signals to the cell cycle machinery via multiple pathways to induce anchorage-independent growth

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7 January 2021

Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways

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7 January 2021

Syndecan-1 is up-regulated in ras-transformed intestinal epithelial cells

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7 January 2021

Oncogenic Ki-ras but not oncogenic Ha-ras blocks integrin beta1-chain maturation in colon epithelial cells

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7 January 2021

Mutant K-ras in apparently normal mucosa of colorectal cancer patients. Its potential as a biomarker of colorectal tumorigenesis

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7 January 2021

Deleted in Colorectal Cancer (DCC) encodes a netrin receptor

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7 January 2021

Mad-related genes in the human

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7 January 2021

Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene

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7 January 2021

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

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7 January 2021

Somatic alterations of the DPC4 gene in human colorectal cancers in vivo

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7 January 2021

MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

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7 January 2021

Predicting response to cancer chemotherapy: the role of p53.

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7 January 2021

Phenotypic variation in colorectal adenoma/cancer expression in two families. Hereditary flat adenoma syndrome

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7 January 2021

Clues to the pathogenesis of familial colorectal cancer

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7 January 2021

Microsatellite instability in cancer of the proximal colon

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7 January 2021

The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)

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7 January 2021

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

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7 January 2021

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

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7 January 2021

Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer.

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7 January 2021

Genetic mapping of a locus predisposing to human colorectal cancer

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7 January 2021

Mutations of two PMS homologues in hereditary nonpolyposis colon cancer

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7 January 2021

Mechanisms and biological effects of mismatch repair

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7 January 2021

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

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7 January 2021

DNA methylation and genetic instability in colorectal cancer cells

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7 January 2021

Hypermutability and mismatch repair deficiency in RER+ tumor cells

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7 January 2021

Microsatellite instability and hereditary non-polyposis colon cancer

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7 January 2021

Morphology of sporadic colorectal cancer with DNA replication errors

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7 January 2021

Mismatch repair genes and mononucleotide tracts as mutation targets in colorectal tumors with different degrees of microsatellite instability

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7 January 2021

Polymerase delta variants in RER colorectal tumours

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7 January 2021

Diploid predominance in hereditary nonpolyposis colorectal carcinoma evaluated by flow cytometry

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7 January 2021

Colorectal adenomas in surgical specimens from subjects with hereditary non-polyposis colorectal cancer

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7 January 2021

APC mutations in colorectal tumors with mismatch repair deficiency

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7 January 2021

Defects in mismatch repair occur afterAPC mutations in the pathogenesis of sporadic colorectal tumours

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7 January 2021

Chromosome number and structure both are markedly stable in RER colorectal cancers and are not destabilized by mutation of p53

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https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

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7 January 2021

Microsatellite instability in the insulin–like growth factor II receptor gene in gastrointestinal tumours

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7 January 2021

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

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7 January 2021

Colorectal cancer in ulcerative colitis: a cohort study of primary referrals from three centres

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7 January 2021

Clinicopathological characteristics of colorectal carcinoma complicating ulcerative colitis

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7 January 2021

Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications.

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7 January 2021

Colonic pericrypt sheath cells: characterisation of cell type with new monoclonal antibody

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7 January 2021

Significance of pericryptal fibroblasts in colorectal epithelial tumors: a special reference to the histologic features and growth patterns

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https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis.

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https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Frequent loss of a p53 allele in carcinomas and their precursors in ulcerative colitis

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7 January 2021

p53 Point mutations in dysplastic and cancerous ulcerative colitis lesions

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7 January 2021

DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis.

1 reference

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7 January 2021

DNA aneuploidy in Crohn's disease and ulcerative colitis: results of a comparative flow cytometric study

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7 January 2021

Flow cytometric DNA ploidy pattern in dysplastic mucosa, and in primary and metastatic carcinomas in patients with longstanding ulcerative colitis

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https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

DNA aneuploidy in ulcerative colitis

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https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Common occurrence of APC and K-ras gene mutations in the spectrum of colitis-associated neoplasias

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7 January 2021

c-Ki-ras gene mutations in dysplasia and carcinomas complicating ulcerative colitis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

c-Ki-ras mutations in chronic ulcerative colitis and sporadic colon carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Regenerative lesions in ulcerative colitis are characterized by microsatellite mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

DNA mismatch repair in lymphoblastoid cells from hereditary non-polyposis colorectal cancer (HNPCC) patients is normal under conditions of rapid cell division and increased mutational load.

1 reference

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7 January 2021

Stereomicroscopic examination of surface morphology in colorectal epithelial tumors

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https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Minute cancers arising de novo in the human large intestine

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7 January 2021

Non-involvement of ras mutations in flat colorectal adenomas and carcinomas

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7 January 2021

Lower incidence of K-ras codon 12 mutation in flat colorectal adenomas than in polypoid adenomas.

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7 January 2021

Comparative clinicopathological and immunohistochemical study of ras and p53 in flat and polypoid type colorectal tumours

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7 January 2021

A clinicopathologic study of small flat colorectal carcinoma

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7 January 2021

How do colorectal cancers develop?

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7 January 2021

Generalized Intestinal Polyposis and Melanin Spots of the Oral Mucosa, Lips and Digits

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7 January 2021

Clinical and molecular features of the hereditary mixed polyposis syndrome

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7 January 2021

Multiple Hamartoma Syndrome (Cowden Disease)

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7 January 2021

Mutations in the SMAD4/DPC4 gene in juvenile polyposis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Infrequent K-ras codon 12 mutation in serrated adenomas of human colorectum

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Frequent p53 gene mutations in serrated adenomas of the colorectum.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Genetic alterations of mixed hyperplastic adenomatous polyps in the colon and rectum.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Relationships between UMPK and PGD activities and deletions of chromosome 1p in colorectal cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Cytogenetic aberrations in colorectal adenocarcinomas and their correlation with clinicopathologic features

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Chromosome 7q deletions: observations on 13 malignant tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Colorectal carcinomas show frequent allelic loss on the long arm of chromosome 17 with evidence for a specific target region

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

17q allele loss is associated with lymph node metastasis in locally aggressive human colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Molecular genetics for clinical management of colorectal carcinoma. 17p, 18q, and 22q loss of heterozygosity and decreased DCC expression are correlated with the metastatic potential

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Frequent loss of heterozygosity at telomeric loci on 22q in sporadic colorectal cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Allele loss in colorectal cancer at the Cowden disease/juvenile polyposis locus on 10q.

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Tissue levels of matrix metalloproteinases MMP-2 and MMP-9 are related to the overall survival of patients with gastric carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Plasminogen activators and inhibitor type 1 in neoplastic colonic tissue from patients with familial adenomatous polyposis

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Overexpression of nm23-H1 and nm23-H2 genes in colorectal carcinomas and loss of nm23-H1 expression in advanced tumour stages

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Allele loss, replication errors and loss of expression of E-cadherin in colorectal cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Homeosis and intestinal tumours in Cdx2 mutant mice

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

Smad3 mutant mice develop metastatic colorectal cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0959-8049%2898%2900431-6

7 January 2021

10.1016/S0959-8049(98)00431-6

Identifiers

DOI

1 reference

28 July 2017

1 reference