Systematic mapping of functional enhancer-promoter connections with CRISPR interference (Q33709312)

28 July 2017

Systematic mapping of functional enhancer-promoter connections with CRISPR interference (English)

1 reference

28 July 2017

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9

Eric S Lander

1 reference

28 July 2017

Sharon R Grossman

5

0 references

Mathias Munschauer

object named as

Mathias Munschauer

2

0 references

Jesse Engreitz

10

object named as

Jesse M Engreitz

1 reference

28 July 2017

1

Charles P Fulco

1 reference

28 July 2017

Rockwell Anyoha

3

1 reference

28 July 2017

Glen Munson

4

1 reference

28 July 2017

Elizabeth M Perez

6

1 reference

28 July 2017

Michael Kane

7

1 reference

28 July 2017

Brian Cleary

8

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28 July 2017

language of work or name

English

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publication date

29 September 2016

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28 July 2017

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28 July 2017

354

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28 July 2017

6313

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28 July 2017

769-773

1 reference

The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)

28 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

High-throughput mapping of regulatory DNA.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

Functional genetic screens for enhancer elements in the human genome using CRISPR-Cas9.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

Integrative analysis of 111 reference human epigenomes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

In search of the determinants of enhancer-promoter interaction specificity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

Transcriptional enhancers: from properties to genome-wide predictions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

An integrated encyclopedia of DNA elements in the human genome

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

Transcription factors: from enhancer binding to developmental control

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

Extensive promoter-centered chromatin interactions provide a topological basis for transcription regulation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

Functional and mechanistic diversity of distal transcription enhancers

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

Targeted deletion of multiple CTCF-binding elements in the human C-MYC gene reveals a requirement for CTCF in C-MYC expression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

Differential contribution of the Gata1 gene hematopoietic enhancer to erythroid differentiation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

A GATA box in the GATA-1 gene hematopoietic enhancer is a critical element in the network of GATA factors and sites that regulate this gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

Different core promoters possess distinct regulatory activities in the Drosophila embryo

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

Developmental regulation of beta-globin gene switching.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

Identification and characterization of essential genes in the human genome.

21 June 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

21 January 2018

You Don't Muck with MYC

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

DNA targeting specificity of RNA-guided Cas9 nucleases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Nucleosomes impede Cas9 access to DNA in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Landscape of transcription in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

FIMO: scanning for occurrences of a given motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

TRANSFAC and its module TRANSCompel: transcriptional gene regulation in eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Sequence determinants of improved CRISPR sgRNA design

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Improved vectors and genome-wide libraries for CRISPR screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

RNA-RNA interactions enable specific targeting of noncoding RNAs to nascent Pre-mRNAs and chromatin sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

A high-throughput chromatin immunoprecipitation approach reveals principles of dynamic gene regulation in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Multiplex genome engineering using CRISPR/Cas systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Mapping and analysis of chromatin state dynamics in nine human cell types

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

The accessible chromatin landscape of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Combinatorial effects of multiple enhancer variants in linkage disequilibrium dictate levels of gene expression to confer susceptibility to common traits

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Looping and interaction between hypersensitive sites in the active beta-globin locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Long-Range Chromatin Interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Reactivation of developmentally silenced globin genes by forced chromatin looping.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Global view of enhancer-promoter interactome in human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Enhancer-promoter interactions are encoded by complex genomic signatures on looping chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Dynamic Control of Enhancer Repertoires Drives Lineage and Stage-Specific Transcription during Hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Chromatin architecture reorganization during stem cell differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Upregulation of c-MYC in cis through a large chromatin loop linked to a cancer risk-associated single-nucleotide polymorphism in colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Bioconductor: open software development for computational biology and bioinformatics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Software for computing and annotating genomic ranges

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

rtracklayer: an R package for interfacing with genome browsers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

BEDTools: a flexible suite of utilities for comparing genomic features

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Integrative genomics viewer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Biopython: freely available Python tools for computational molecular biology and bioinformatics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Genetic screens in human cells using the CRISPR-Cas9 system

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Genome-scale CRISPR-Cas9 knockout screening in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Unlinking an lncRNA from Its Associated cis Element

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Diversifying microRNA sequence and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Accurate prediction of inducible transcription factor binding intensities in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Genome-wide quantitative enhancer activity maps identified by STARR-seq

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Histone H3K27ac separates active from poised enhancers and predicts developmental state

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Comprehensive mapping of long-range interactions reveals folding principles of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

GATA-1-mediated proliferation arrest during erythroid maturation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

The distinctive roles of erythroid specific activator GATA-1 and NF-E2 in transcription of the human fetal γ-globin genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

Enhancer-dependent transcription of the epsilon-globin promoter requires promoter-bound GATA-1 and enhancer-bound AP-1/NF-E2

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2445

A putative role for histone deacetylase in the differentiation of human erythroid cells.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5438575

30 October 2018

Identifiers

DOI

10.1126/SCIENCE.AAG2445

1 reference

28 July 2017

0 references

1 reference

28 July 2017

1 reference