Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner. (Q33668452)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24627160%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

title

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner (English)

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10 March 2020

11

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10 March 2020

Arjuna Rajakumar

13

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10 March 2020

Ivan Topisirovic

14

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10 March 2020

12

Valentina Gandin

1 reference

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10 March 2020

author name string

Rachel Miloslavski

1

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10 March 2020

Elad Cohen

2

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10 March 2020

Adam Avraham

3

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10 March 2020

Yifat Iluz

4

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10 March 2020

Zvi Hayouka

5

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10 March 2020

Judith Kasir

6

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10 March 2020

Rajini Mudhasani

7

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10 March 2020

Stephen N Jones

8

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10 March 2020

Nadine Cybulski

9

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10 March 2020

Markus A Rüegg

10

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10 March 2020

Oded Meyuhas

15

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10 March 2020

publication date

13 March 2014

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Journal of Molecular Cell Biology

10 March 2020

published in

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10 March 2020

volume

6

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10 March 2020

page(s)

255-266

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10 March 2020

issue

3

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mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts

10 March 2020

cites work

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Amino acid signalling upstream of mTOR

21 June 2018

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Distinct perturbation of the translatome by the antidiabetic drug metformin

21 June 2018

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A unifying model for mTORC1-mediated regulation of mRNA translation.

21 June 2018

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Regulation of TOR by small GTPases

21 June 2018

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Inducible raptor and rictor knockout mouse embryonic fibroblasts

21 June 2018

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Rapamycin passes the torch: a new generation of mTOR inhibitors

21 June 2018

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Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR.

21 June 2018

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21 June 2018

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mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry

21 June 2018

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Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1

21 June 2018

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Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress

21 June 2018

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mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

21 June 2018

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Ribosomal protein S6 kinase from TOP mRNAs to cell size

21 June 2018

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Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis

21 June 2018

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Synthesis and function of ribosomal proteins--fading models and new perspectives

21 June 2018

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Regulation of oxygen homeostasis by hypoxia-inducible factor 1.

21 June 2018

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An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

21 June 2018

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The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner

21 June 2018

1 reference

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

21 June 2018

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Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells

21 June 2018

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Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

21 June 2018

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Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs

21 June 2018

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MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation

21 June 2018

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

21 June 2018

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 June 2018

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Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

21 June 2018

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Bnip3 mediates the hypoxia-induced inhibition on mammalian target of rapamycin by interacting with Rheb

21 June 2018

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Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner

21 June 2018

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AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling

21 June 2018

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Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2

21 June 2018

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

21 June 2018

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5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments

21 June 2018

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Hypoxia-induced energy stress regulates mRNA translation and cell growth

21 June 2018

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Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis

21 June 2018

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Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

21 June 2018

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Regulation of mTOR and cell growth in response to energy stress by REDD1.

21 June 2018

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Lithium can relieve translational repression of TOP mRNAs elicited by various blocks along the cell cycle in a glycogen synthase kinase-3- and S6-kinase-independent manner

21 June 2018

1 reference

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S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway

21 June 2018

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TSC2 mediates cellular energy response to control cell growth and survival

21 June 2018

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Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

21 June 2018

1 reference

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Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

21 June 2018

1 reference

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Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation

21 June 2018

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Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

21 June 2018

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Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.

21 June 2018

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A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells

21 June 2018

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Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

21 June 2018

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Translational control is required for the unfolded protein response and in vivo glucose homeostasis

21 June 2018

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Regulation of translation initiation by FRAP/mTOR

21 June 2018

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HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

21 June 2018

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Vertebrate mRNAs with a 5'-terminal pyrimidine tract are candidates for translational repression in quiescent cells: characterization of the translational cis-regulatory element.

21 June 2018

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Overexpression of initiation factor eIF-4E does not relieve the translational repression of ribosomal protein mRNAs in quiescent cells

21 June 2018

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G1 events and regulation of cell proliferation

21 June 2018

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Oligopyrimidine tract at the 5' end of mammalian ribosomal protein mRNAs is required for their translational control

21 June 2018

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Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

21 June 2018

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A regulatory cis element and a specific binding factor involved in the mitogenic control of murine ribosomal protein L32 translation

21 June 2018

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Building ribosomes: even more expensive than expected?

21 June 2018

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Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies.

21 January 2018

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Comparison of methylated sequences in messenger RNA and heterogeneous nuclear RNA from mouse L cells

21 January 2018

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12 December 2020

AXenopus laevisHomologue of the La Autoantigen Binds the Pyrimidine Tract of the 5′ UTR of Ribosomal Protein mRNAsin Vitro: Implication of a Protein Factor in Complex Formation

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12 December 2020

Cellular nucleic acid binding protein binds a conserved region of the 5' UTR of Xenopus laevis ribosomal protein mRNAs

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12 December 2020

Stable isotope-labelling analysis of the impact of inhibition of the mammalian target of rapamycin on protein synthesis

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12 December 2020

Identifiers

DOI

10.1093/JMCB/MJU008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24627160%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24627160%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24627160%20AND%20SRC:MED&resulttype=core&format=json