Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms. (Q33659512)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24867637%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

title

Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms (English)

1 reference

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19 March 2020

7

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19 March 2020

Matthew D Galbraith

8

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19 March 2020

Robin D. Dowell

11

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19 March 2020

12

Joaquin M Espinosa

1 reference

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19 March 2020

2

Zdenek Andrysik

1 reference

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19 March 2020

3

Veronica L Dengler

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19 March 2020

author name string

Mary Ann Allen

1

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19 March 2020

Hestia S Mellert

4

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19 March 2020

Anna Guarnieri

5

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19 March 2020

Justin A Freeman

6

1 reference

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19 March 2020

Xin Luo

9

1 reference

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19 March 2020

W Lee Kraus

10

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19 March 2020

language of work or name

English

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publication date

27 May 2014

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19 March 2020

1 reference

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19 March 2020

volume

3

1 reference

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19 March 2020

page(s)

e02200

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24867637%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

19 March 2020

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4033189/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

DESeq2

object named as

DEseq

DESeq

1 reference

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

DESeq2

0 references

cites work

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p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes

14 July 2018

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Mapping the p53 transcriptome universe using p53 natural polymorphs

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Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions.

14 July 2018

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Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells

14 July 2018

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A genetic screen identifies TCF3/E2A and TRIAP1 as pathway-specific regulators of the cellular response to p53 activation.

14 July 2018

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eRNAs are required for p53-dependent enhancer activity and gene transcription

14 July 2018

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Mdm2 and MdmX as Regulators of Gene Expression

14 July 2018

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Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis

14 July 2018

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ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.

14 July 2018

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Systematic identification of genomic markers of drug sensitivity in cancer cells

14 July 2018

1 reference

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Distinct regulatory mechanisms and functions for p53-activated and p53-repressed DNA damage response genes in embryonic stem cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

A DR4:tBID axis drives the p53 apoptotic response by promoting oligomerization of poised BAX.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

Capture of microRNA-bound mRNAs identifies the tumor suppressor miR-34a as a regulator of growth factor signaling

14 July 2018

1 reference

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A rapid, extensive, and transient transcriptional response to estrogen signaling in breast cancer cells

14 July 2018

1 reference

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Role of p53 serine 46 in p53 target gene regulation

14 July 2018

1 reference

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Differential expression analysis for sequence count data

14 July 2018

1 reference

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Regulation of the p53 transcriptional response by structurally diverse core promoters

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

Awakening guardian angels: drugging the p53 pathway

14 July 2018

1 reference

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Control of inducible gene expression by signal-dependent transcriptional elongation

14 July 2018

1 reference

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Blinded by the Light: The Growing Complexity of p53

14 July 2018

1 reference

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Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters

14 July 2018

1 reference

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Characterization of genome-wide p53-binding sites upon stress response.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

Transcriptional control of human p53-regulated genes

14 July 2018

1 reference

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Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

BLIMP1 regulates cell growth through repression of p53 transcription.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

Excess HDM2 impacts cell cycle and apoptosis and has a selective effect on p53-dependent transcription.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

Mouse double minute 2 associates with chromatin in the presence of p53 and is released to facilitate activation of transcription

14 July 2018

1 reference

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Transcriptional regulation by p53: one protein, many possibilities

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

A global map of p53 transcription-factor binding sites in the human genome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

p53 Functions through Stress- and Promoter-Specific Recruitment of Transcription Initiation Components before and after DNA Damage

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

Kinetics of p53 binding to promoter sites in vivo

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

Analysis of p53-regulated gene expression patterns using oligonucleotide arrays

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

Characterization of a new intrabody directed against the N-terminal region of human p53.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

Constitutive expression of the cyclin-dependent kinase inhibitor p21 is transcriptionally regulated by the tumor suppressor protein p53.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

A model for p53-induced apoptosis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

Repression of p53-mediated transcription by MDM2: a dual mechanism

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

Regulation of p53 stability by Mdm2

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

WAF1, a potential mediator of p53 tumor suppression

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

The C terminus of p53 binds the N-terminal domain of MDM2.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

Amplification and overexpression of the MDM4 (MDMX) gene from 1q32 in a subset of malignant gliomas without TP53 mutation or MDM2 amplification.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4033189

p53 status and the efficacy of cancer therapy in vivo

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24867637

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24867637

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.7554/ELIFE.02200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24867637%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24867637%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24867637%20AND%20SRC:MED&resulttype=core&format=json