Endogenous IGF-I and alphaVbeta3 integrin ligands regulate increased smooth muscle hyperplasia in stricturing Crohn's disease (Q33618488)

28 July 2017

title

Endogenous IGF-I and alphaVbeta3 integrin ligands regulate increased smooth muscle hyperplasia in stricturing Crohn's disease (English)

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28 July 2017

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Robert S Flynn

1

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28 July 2017

Karnam S Murthy

2

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28 July 2017

John R Grider

3

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28 July 2017

John M Kellum

4

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28 July 2017

John F Kuemmerle

5

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28 July 2017

language of work or name

English

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publication date

12 September 2009

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28 July 2017

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28 July 2017

volume

138

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28 July 2017

issue

1

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28 July 2017

page(s)

285-293

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Clinical review of Crohn's disease

28 July 2017

cites work

1 reference

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21 June 2018

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Coupling of the insulin-like growth factor-I receptor tyrosine kinase to Gi2 in human intestinal smooth muscle: Gbetagamma -dependent mitogen-activated protein kinase activation and growth

21 June 2018

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Strictures in Crohn's disease are characterised by an accumulation of mast cells colocalised with laminin but not with fibronectin or vitronectin

21 June 2018

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Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice

21 June 2018

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IGF-I stimulates intestinal muscle cell growth by activating distinct PI 3-kinase and MAP kinase pathways

21 June 2018

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Targeted overexpression of IGF-I evokes distinct patterns of organ remodeling in smooth muscle cell tissue beds of transgenic mice

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Ligand occupancy of the alpha-V-beta3 integrin is necessary for smooth muscle cells to migrate in response to insulin-like growth factor

21 June 2018

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Collagen content and types in the intestinal strictures of Crohn's disease

21 June 2018

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Transforming growth factor beta 1 selectively augments collagen synthesis by human intestinal smooth muscle cells

21 June 2018

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Differential changes in brain-derived neurotrophic factor and extracellular signal-regulated kinase in rat primary afferent pathways with colitis

21 June 2018

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Occupation of alphavbeta3-integrin by endogenous ligands modulates IGF-I receptor activation and proliferation of human intestinal smooth muscle

30 October 2018

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Endogenous IGF-I protects human intestinal smooth muscle cells from apoptosis by regulation of GSK-3 beta activity

30 October 2018

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IGF-I elicits growth of human intestinal smooth muscle cells by activation of PI3K, PDK-1, and p70S6 kinase

30 October 2018

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The alphaVbeta3 integrin regulates insulin-like growth factor I (IGF-I) receptor phosphorylation by altering the rate of recruitment of the Src-homology 2-containing phosphotyrosine phosphatase-2 to the activated IGF-I receptor

30 October 2018

1 reference

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Insulin-like growth factor-binding protein-5 (IGFBP-5) stimulates growth and IGF-I secretion in human intestinal smooth muscle by Ras-dependent activation of p38 MAP kinase and Erk1/2 pathways

30 October 2018

1 reference

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Reduced serum insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 levels in adults with inflammatory bowel disease.

30 October 2018

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Expression of insulin-like growth factor binding proteins and collagen in experimental colitis in rats

30 October 2018

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Endogenous IGF-I regulates IGF binding protein production in human intestinal smooth muscle cells

30 October 2018

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Reduction in atherosclerotic lesion size in pigs by alphaVbeta3 inhibitors is associated with inhibition of insulin-like growth factor-I-mediated signaling

30 October 2018

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Expression of endothelial nitric oxide synthase in human and rabbit gastrointestinal smooth muscle cells.

30 October 2018

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Insulin-like growth factor I and insulin-like growth factor binding protein 5 in Crohn's disease

30 October 2018

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12 December 2020

Mesenchymal IGF-I overexpression: paracrine effects in the intestine, distinct from endocrine actions

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12 December 2020

Integrins in regulation of tissue development and function

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12 December 2020

Thickening of muscularis mucosae in Crohn's disease

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12 December 2020

Insulinlike growth factor I and interleukin 1 beta messenger RNA in a rat model of granulomatous enterocolitis and hepatitis

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12 December 2020

Enhanced growth of small bowel in transgenic mice expressing human insulin-like growth factor I

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12 December 2020

Synthetic alphaVbeta3 antagonists inhibit insulin-like growth factor-I-stimulated smooth muscle cell migration and replication

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12 December 2020

Growth hormone reduces the severity of fibrosis associated with chronic intestinal inflammation

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12 December 2020

10.1053/J.GASTRO.2009.09.003

Identifiers

DOI

1 reference

release_njuge6hfcrgzxj5rygq2cscrsi

28 July 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/njuge6hfcrgzxj5rygq2cscrsi

24 November 2022

mapped directly with Wikidata item

PMC publication ID

2813387

1 reference

28 July 2017

1 reference