Intended transcriptional silencing with siRNA results in gene repression through sequence-specific off-targeting (Q33611634)

28 July 2017

Intended transcriptional silencing with siRNA results in gene repression through sequence-specific off-targeting (English)

1 reference

28 July 2017

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Joshua Moses

1

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28 July 2017

Amber Goodchild

series ordinal

2

1 reference

28 July 2017

Laurent P Rivory

series ordinal

3

1 reference

28 July 2017

language of work or name

English

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publication date

21 December 2009

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28 July 2017

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28 July 2017

16

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28 July 2017

2

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28 July 2017

430-441

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describes a project that uses

28 July 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2811671/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells

1 reference

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Off-target effects of siRNA specific for GFP

21 June 2018

1 reference

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An RNA targeted to the HIV-1 LTR promoter modulates indiscriminate off-target gene activation

21 June 2018

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MicroRNA targeting specificity in mammals: determinants beyond seed pairing

21 June 2018

1 reference

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MAP kinase signalling pathways in cancer

21 June 2018

1 reference

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Integrating signals from RTKs to ERK/MAPK.

21 June 2018

1 reference

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Neuropilin-1 promotes human glioma progression through potentiating the activity of the HGF/SF autocrine pathway

21 June 2018

1 reference

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Activating gene expression in mammalian cells with promoter-targeted duplex RNAs

21 June 2018

1 reference

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Small dsRNAs induce transcriptional activation in human cells

21 June 2018

1 reference

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Argonaute-1 directs siRNA-mediated transcriptional gene silencing in human cells

21 June 2018

1 reference

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Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811671

Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity

21 June 2018

1 reference

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3' UTR seed matches, but not overall identity, are associated with RNAi off-targets

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811671

The role of transcriptional coactivator TRAP220 in myelomonocytic differentiation

21 June 2018

1 reference

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Short double-stranded RNA induces transcriptional gene silencing in human cancer cells in the absence of DNA methylation

21 June 2018

1 reference

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Principles of microRNA-target recognition

21 June 2018

1 reference

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Inhibition of angiogenesis by growth factor receptor bound protein 2-Src homology 2 domain bound antagonists

21 June 2018

1 reference

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Constitutive and inducible expression and regulation of vascular endothelial growth factor

21 June 2018

1 reference

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Fast and effective prediction of microRNA/target duplexes

21 June 2018

1 reference

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A small modulatory dsRNA specifies the fate of adult neural stem cells

21 June 2018

1 reference

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Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

21 June 2018

1 reference

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Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery

21 June 2018

1 reference

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Expression profiling reveals off-target gene regulation by RNAi

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811671

A comparison of normalization methods for high density oligonucleotide array data based on variance and bias

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811671

Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811671

Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811671

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 June 2018

1 reference

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Role for a bidentate ribonuclease in the initiation step of RNA interference

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811671

RNA interference is mediated by 21- and 22-nucleotide RNAs

21 June 2018

1 reference

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Met receptor tyrosine kinase: enhanced signaling through adapter proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811671

Transcriptional silencing and promoter methylation triggered by double-stranded RNA

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811671

RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals

21 June 2018

1 reference

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A species of small antisense RNA in posttranscriptional gene silencing in plants

21 June 2018

1 reference

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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811671

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811671

The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811671

Short hairpin RNA-directed cytosine (CpG) methylation of the RASSF1A gene promoter in HeLa cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811671

SiRNA-mediated inhibition of vascular endothelial growth factor severely limits tumor resistance to antiangiogenic thrombospondin-1 and slows tumor vascularization and growth.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811671

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811671

30 October 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/20026621

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Perfect seed pairing is not a generally reliable predictor for miRNA-target interactions

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20026621

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1261/RNA.1808510

1 reference

28 July 2017

1 reference

28 July 2017

1 reference