Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1 (Q24685178)

2

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Natalia Martínez

3

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Rocío Jorge

4

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Alicia Ballester

5

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Silvia Gutiérrez-Eisman

6

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Susana García-Vargas

7

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José M Rojas

Molecular Biology of the Cell

8

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language of work or name

English

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publication date

August 2006

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published in

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volume

17

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issue

8

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page(s)

3591-7

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cites work

A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1

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An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine

7 April 2017

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The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain

7 April 2017

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The structural basis of the activation of Ras by Sos

7 April 2017

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Regulation of Sos activity by intramolecular interactions

7 April 2017

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Tandem histone folds in the structure of the N-terminal segment of the ras activator Son of Sevenless

7 April 2017

1 reference

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Direct interaction of SOS1 Ras exchange protein with the SH3 domain of phospholipase C-gamma1

7 April 2017

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EPS8 and E3B1 transduce signals from Ras to Rac

7 April 2017

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JNK activation is critical for Aplidin-induced apoptosis.

7 April 2017

1 reference

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Grb2 regulates internalization of EGF receptors through clathrin-coated pits

28 September 2017

1 reference

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Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1525251

HSos1 contains a new amino-terminal regulatory motif with specific binding affinity for its pleckstrin homology domain

28 September 2017

1 reference

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Mechanisms through which Sos-1 coordinates the activation of Ras and Rac.

28 September 2017

1 reference

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The isoform-specific stretch of hSos1 defines a new Grb2-binding domain

28 September 2017

1 reference

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Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

28 September 2017

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Grb2 SH3 binding to peptides from Sos: evaluation of a general model for SH3-ligand interactions

28 September 2017

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A 15 amino acid stretch close to the Grb2-binding domain defines two differentially expressed hSos1 isoforms with markedly different Grb2 binding affinity and biological activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1525251

Catalytic activity of the mouse guanine nucleotide exchanger mSOS is activated by Fyn tyrosine protein kinase and the T-cell antigen receptor in T cells

28 September 2017

1 reference

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Cloning of a Grb2 isoform with apoptotic properties

28 September 2017

1 reference

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Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

28 September 2017

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Phosphorylation of the Ras nucleotide exchange factor son of sevenless by mitogen-activated protein kinase.

28 September 2017

1 reference

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The Grb2 binding domain of mSos1 is not required for downstream signal transduction

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1525251

Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1525251

Isoform-specific insertion near the Grb2-binding domain modulates the intrinsic guanine nucleotide exchange activity of hSos1.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1525251

Functional roles for the pleckstrin and Dbl homology regions in the Ras exchange factor Son-of-sevenless

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1525251

EGF induced SOS phosphorylation in PC12 cells involves P90 RSK-2

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1525251

Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation

28 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/16760435