Probing the molecular mechanism of action of the HIV-1 reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) using pre-steady-state kinetics (Q33610945)

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English	Probing the molecular mechanism of action of the HIV-1 reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) using pre-steady-state kinetics	scientific article

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scholarly article

1 reference

Europe PubMed Central

28 July 2017

Probing the molecular mechanism of action of the HIV-1 reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) using pre-steady-state kinetics (English)

1 reference

Europe PubMed Central

28 July 2017

Stefan G. Sarafianos

5

1 reference

Europe PubMed Central

28 July 2017

author name string

Yagmur Muftuoglu

1

1 reference

Europe PubMed Central

28 July 2017

Christal D Sohl

2

1 reference

Europe PubMed Central

28 July 2017

Andrea C Mislak

3

1 reference

Europe PubMed Central

28 July 2017

Hiroaki Mitsuya

4

1 reference

Europe PubMed Central

28 July 2017

Karen S Anderson

6

1 reference

Europe PubMed Central

28 July 2017

publication date

12 March 2014

1 reference

Europe PubMed Central

28 July 2017

Antiviral Research

1 reference

Europe PubMed Central

28 July 2017

106

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Europe PubMed Central

28 July 2017

1-4

1 reference

Europe PubMed Central

28 July 2017

Effects of substitutions at the 4' and 2 positions on the bioactivity of 4'-ethynyl-2-fluoro-2'-deoxyadenosine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020981

21 June 2018

Preformulation studies of EFdA, a novel nucleoside reverse transcriptase inhibitor for HIV prevention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020981

21 June 2018

Hypersusceptibility mechanism of Tenofovir-resistant HIV to EFdA.

1 reference

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21 June 2018

Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients

1 reference

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21 June 2018

Understanding the molecular mechanism of sequence dependent tenofovir removal by HIV-1 reverse transcriptase: differences in primer binding site versus polypurine tract

1 reference

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21 June 2018

Balancing antiviral potency and host toxicity: identifying a nucleotide inhibitor with an optimal kinetic phenotype for HIV-1 reverse transcriptase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020981

21 June 2018

Nucleocapsid protein annealing of a primer-template enhances (+)-strand DNA synthesis and fidelity by HIV-1 reverse transcriptase

1 reference

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21 June 2018

Mechanism of interaction of human mitochondrial DNA polymerase γ with the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine indicates a low potential for host toxicity.

1 reference

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21 June 2018

Mitochondrial interference by anti-HIV drugs: mechanisms beyond Pol-γ inhibition

1 reference

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21 June 2018

Role of induced fit in limiting discrimination against AZT by HIV reverse transcriptase

1 reference

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21 June 2018

The sugar ring conformation of 4'-ethynyl-2-fluoro-2'-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020981

21 June 2018

Mutation of HIV-1 genomes in a clinical population treated with the mutagenic nucleoside KP1461

1 reference

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21 June 2018

Mechanism of inhibition of HIV-1 reverse transcriptase by 4'-Ethynyl-2-fluoro-2'-deoxyadenosine triphosphate, a translocation-defective reverse transcriptase inhibitor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020981

21 June 2018

Delayed chain termination protects the anti-hepatitis B virus drug entecavir from excision by HIV-1 reverse transcriptase

1 reference

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21 June 2018

Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020981

21 June 2018

KP-1212/1461, a nucleoside designed for the treatment of HIV by viral mutagenesis

1 reference

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21 June 2018

Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase.

1 reference

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21 June 2018

Mechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTP

1 reference

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21 June 2018

Mechanistic studies comparing the incorporation of (+) and (-) isomers of 3TCTP by HIV-1 reverse transcriptase

1 reference

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21 June 2018

RNA dependent DNA replication fidelity of HIV-1 reverse transcriptase: evidence of discrimination between DNA and RNA substrates

1 reference

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21 June 2018

2'-deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against wide spectrum of HIV-1 strains, favorable toxic profiles, and stability in plasma.

1 reference

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30 October 2018

Pre-steady-state kinetic studies establish entecavir 5'-triphosphate as a substrate for HIV-1 reverse transcriptase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020981

30 October 2018

Mechanism of action of a novel viral mutagenic covert nucleotide: molecular interactions with HIV-1 reverse transcriptase and host cell DNA polymerases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4020981

30 October 2018

Mechanistic studies to understand the progressive development of resistance in human immunodeficiency virus type 1 reverse transcriptase to abacavir

1 reference

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30 October 2018

Identifiers

10.1016/J.ANTIVIRAL.2014.03.001

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

1 reference

Europe PubMed Central

28 July 2017

ResearchGate publication ID

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