Mechanism of interaction of human mitochondrial DNA polymerase γ with the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine indicates a low potential for host toxicity. (Q35806294)

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scientific article published on 12 December 2011

Language	Label	Description	Also known as
English	Mechanism of interaction of human mitochondrial DNA polymerase γ with the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine indicates a low potential for host toxicity.	scientific article published on 12 December 2011

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scholarly article

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18 January 2020

Mechanism of interaction of human mitochondrial DNA polymerase γ with the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine indicates a low potential for host toxicity (English)

1 reference

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18 January 2020

mitochondrial DNA

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Stefan G. Sarafianos

6

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18 January 2020

William C Copeland

4

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18 January 2020

author name string

Christal D Sohl

1

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18 January 2020

Kamlendra Singh

2

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18 January 2020

Rajesh Kasiviswanathan

3

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18 January 2020

Hiroaki Mitsuya

5

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18 January 2020

Karen S Anderson

7

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18 January 2020

language of work or name

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publication date

12 December 2011

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18 January 2020

Antimicrobial Agents and Chemotherapy

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18 January 2020

56

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18 January 2020

1630-1634

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18 January 2020

3

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18 January 2020

The sugar ring conformation of 4'-ethynyl-2-fluoro-2'-deoxyadenosine and its recognition by the polymerase active site of HIV reverse transcriptase.

1 reference

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Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA.

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1 reference

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Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations

1 reference

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Interaction of 2'-deoxyguanosine triphosphate analogue inhibitors of HIV reverse transcriptase with human mitochondrial DNA polymerase gamma

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A brief overview of mechanisms of mitochondrial toxicity from NRTIs

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Functional human mitochondrial DNA polymerase gamma forms a heterotrimer

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Potent activity of a nucleoside reverse transcriptase inhibitor, 4'-ethynyl-2-fluoro-2'-deoxyadenosine, against human immunodeficiency virus type 1 infection in a model using human peripheral blood mononuclear cell-transplanted NOD/SCID Janus kinase

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Activity against human immunodeficiency virus type 1, intracellular metabolism, and effects on human DNA polymerases of 4'-ethynyl-2-fluoro-2'-deoxyadenosine

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Exonuclease proofreading by human mitochondrial DNA polymerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22155823

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial toxicity of nucleoside analogue reverse transcriptase inhibitors: a looming obstacle for long-term antiretroviral therapy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/22155823

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.05729-11

1 reference

Europe PubMed Central

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18 January 2020

1 reference

Europe PubMed Central

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18 January 2020

1 reference

Europe PubMed Central

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18 January 2020

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