Mammalian X-ray-sensitive mutants which are defective in non-homologous (illegitimate) DNA double-strand break repair (Q33601058)

28 July 2017

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title

Mammalian X-ray-sensitive mutants which are defective in non-homologous (illegitimate) DNA double-strand break repair (English)

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28 July 2017

Zdzienicka MZ

1

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28 July 2017

publication date

1 January 1999

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28 July 2017

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28 July 2017

volume

81

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28 July 2017

issue

1-2

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28 July 2017

page(s)

107-116

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DNA double-strand breaks: their repair and relationship to cell killing in yeast

28 July 2017

cites work

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Recombination and joining: different means to the same ends

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7 January 2021

Functions of the yeast meiotic recombination genes, MRE11 and MRE2.

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7 January 2021

The RAD52 epistasis group in mammalian double strand break repair

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7 January 2021

Model for Homologous Recombination During Transfer of DNA into Mouse L Cells: Role for DNA Ends in the Recombination Process

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7 January 2021

Relative rates of homologous and nonhomologous recombination in transfected DNA.

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7 January 2021

Homology-directed repair is a major double-strand break repair pathway in mammalian cells

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7 January 2021

Association of BRCA1 with Rad51 in mitotic and meiotic cells

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7 January 2021

RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein

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7 January 2021

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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7 January 2021

Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks

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7 January 2021

Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage

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7 January 2021

Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis

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7 January 2021

Stimulation of the DNA-dependent protein kinase by poly(ADP-ribose) polymerase.

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7 January 2021

The XRCC2 DNA repair gene: identification of a positional candidate

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7 January 2021

DNA-PK: at the cross-roads of biochemistry and genetics

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7 January 2021

Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen

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7 January 2021

DNA-dependent protein kinase: DNA binding and activation in the absence of Ku

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7 January 2021

DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

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7 January 2021

Cell cycle control and cancer

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7 January 2021

DNA-dependent protein kinase

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7 January 2021

DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus

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7 January 2021

V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair

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7 January 2021

Impairment of V(D)J recombination in double-strand break repair mutants

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7 January 2021

A severe combined immunodeficiency mutation in the mouse

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7 January 2021

The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses

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7 January 2021

Specificity in V(D)J recombination: new lessons from biochemistry and genetics

1 reference

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7 January 2021

The scid mutation in mice causes a general defect in DNA repair

1 reference

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7 January 2021

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair

1 reference

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7 January 2021

A link between double-strand break-related repair and V(D)J recombination: the scid mutation

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7 January 2021

DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK.

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7 January 2021

KARP-1: a novel leucine zipper protein expressed from the Ku86 autoantigen locus is implicated in the control of DNA-dependent protein kinase activity

1 reference

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7 January 2021

KARP-1 is induced by DNA damage in a p53- and ataxia telangiectasia mutated-dependent fashion

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https://api.crossref.org/works/10.1016%2FS0300-9084%2899%2980043-1

7 January 2021

Molecular and biochemical characterization of new X-ray-sensitive hamster cell mutants defective in Ku80.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2899%2980043-1

7 January 2021

Isolation of mammalian cell mutants that are X-ray sensitive, impaired in DNA double-strand break repair and defective for V(D)J recombination.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2899%2980043-1

7 January 2021

A DNA end-binding factor involved in double-strand break repair and V(D)J recombination

1 reference

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7 January 2021

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

1 reference

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7 January 2021

DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair

1 reference

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7 January 2021

Gene mutation and V(D)J recombination in the radiosensitive irs lines

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7 January 2021

Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA.

1 reference

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7 January 2021

Complementation of the ionizing radiation sensitivity, DNA end binding, and V(D)J recombination defects of double-strand break repair mutants by the p86 Ku autoantigen

1 reference

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7 January 2021

Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants

1 reference

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7 January 2021

Restoration of X-ray and etoposide resistance, Ku-end binding activity and V(D) J recombination to the Chinese hamster sxi-3 mutant by a hamster Ku86 cDNA.

1 reference

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7 January 2021

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

1 reference

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7 January 2021

Molecular and biochemical characterization of xrs mutants defective in Ku80.

1 reference

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7 January 2021

Disruption of DNA-PK in Ku80 mutant xrs-6 and the implications in DNA double-strand break repair

1 reference

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7 January 2021

The V(D)J recombination defect in the xrs-6 cell line results from a point mutation in the Ku80 gene

1 reference

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7 January 2021

Protein-protein and protein-DNA interaction regions within the DNA end-binding protein Ku70-Ku86.

1 reference

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7 January 2021

A central region of Ku80 mediates interaction with Ku70 in vivo

1 reference

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7 January 2021

Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2899%2980043-1

7 January 2021

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1 reference

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7 January 2021

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

1 reference

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7 January 2021

Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2899%2980043-1

7 January 2021

Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2899%2980043-1

7 January 2021

Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.

1 reference

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7 January 2021

XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation

1 reference

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7 January 2021

Murine cell line SX9 bearing a mutation in the dna-pkcs gene exhibits aberrant V(D)J recombination not only in the coding joint but also in the signal joint

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2899%2980043-1

7 January 2021

The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination.

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2899%2980043-1

7 January 2021

Biochemical and genetic defects in the DNA-dependent protein kinase in murine scid lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2899%2980043-1

7 January 2021

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse

1 reference

https://api.crossref.org/works/10.1016%2FS0300-9084%2899%2980043-1

7 January 2021

Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice

1 reference

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7 January 2021

Molecular and biochemical characterisation of DNA-dependent protein kinase-defective rodent mutant irs-20

1 reference

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7 January 2021

Characterization of two DNA double-stranded break repair-deficient cell lines that express inactive DNA-dependent protein kinase catalytic subunits

1 reference

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7 January 2021

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

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7 January 2021

Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

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7 January 2021

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

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7 January 2021

The XRCC4 gene product is a target for and interacts with the DNA-dependent protein kinase

1 reference

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7 January 2021

Human Rad50 is physically associated with human Mre11: identification of a conserved multiprotein complex implicated in recombinational DNA repair

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7 January 2021

Isolation and characterization of the human MRE11 homologue

1 reference

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7 January 2021

hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks

1 reference

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7 January 2021

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

1 reference

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7 January 2021

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

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7 January 2021

Positional cloning of the gene for Nijmegen breakage syndrome

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7 January 2021

Nijmegen Breakage syndrome: a progress report

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7 January 2021

Nijmegen breakage syndrome

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7 January 2021

Ataxia-telangiectasia: is ATM a sensor of oxidative damage and stress?

1 reference

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7 January 2021

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1 reference

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7 January 2021

Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation

1 reference

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7 January 2021

Cell cycle checkpoints and DNA repair in Nijmegen breakage syndrome

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7 January 2021

Hypersensitivity of cells from a new chromosomal-breakage syndrome to DNA-damaging agents

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7 January 2021

Fibroblasts from ataxia telangiectasia (AT) and AT heterozygotes show an enhanced level of residual DNA double-strand breaks after low dose-rate gamma-irradiation as assayed by pulsed field gel electrophoresis

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7 January 2021

The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

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7 January 2021

The sbcC and sbcD genes of Escherichia coli encode a nuclease involved in palindrome inviability and genetic recombination.

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7 January 2021

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

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7 January 2021

Mutations in two Ku homologs define a DNA end-joining repair pathway in Saccharomyces cerevisiae

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7 January 2021

Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated

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7 January 2021

Evidence for DNA-PK-dependent and -independent DNA double-strand break repair pathways in mammalian cells as a function of the cell cycle

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7 January 2021

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

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7 January 2021

Cell-cycle regulation of mammalian DNA double-strand-break repair

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7 January 2021

Genetic diversity of mitomycin C-hypersensitive Chinese hamster cell mutants: a new complementation group with chromosomal instability

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7 January 2021

A novel type of X-ray-sensitive Chinese hamster cell mutant with radioresistant DNA synthesis and hampered DNA double-strand break repair

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7 January 2021

An instance of clinical radiation morbidity and cellular radiosensitivity, not associated with ataxia-telangiectasia

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7 January 2021

Mammalian mutants defective in the response to ionizing radiation-induced DNA damage

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7 January 2021

V(D)J recombination and double-strand break repair

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7 January 2021

10.1016/S0300-9084(99)80043-1

Identifiers

DOI

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28 July 2017

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