Mapping of allosteric druggable sites in activation-associated conformers of the M2 muscarinic receptor (Q33577530)

28 July 2017

Mapping of allosteric druggable sites in activation-associated conformers of the M2 muscarinic receptor (English)

1 reference

28 July 2017

3

J Andrew McCammon

1 reference

28 July 2017

Yinglong Miao

1

0 references

author name string

Sara E Nichols

series ordinal

2

1 reference

PubMed ID

24112716

28 July 2017

language of work or name

1 reference

30 October 2013

1 reference

Chemical Biology and Drug Design

28 July 2017

1 reference

28 July 2017

83

1 reference

28 July 2017

2

1 reference

28 July 2017

237-246

1 reference

Activation and dynamic network of the M2 muscarinic receptor

28 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

The structural basis of G-protein-coupled receptor signaling (Nobel Lecture)

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

Routine Access to Millisecond Time Scale Events with Accelerated Molecular Dynamics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

FTMAP: extended protein mapping with user-selected probe molecules

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

Structure and dynamics of the M3 muscarinic acetylcholine receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

Activation mechanism of the β2-adrenergic receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

Studying functional dynamics in bio-molecules using accelerated molecular dynamics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

The best of both worlds? Bitopic orthosteric/allosteric ligands of g protein-coupled receptors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

Crystal structure of the β2 adrenergic receptor-Gs protein complex

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

Structure of a nanobody-stabilized active state of the β(2) adrenoceptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

G protein-coupled receptors: novel targets for drug discovery in cancer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

Atomic-level characterization of the structural dynamics of proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

Energy landscapes as a tool to integrate GPCR structure, dynamics, and function

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

Mapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

Crystal structure of opsin in its G-protein-interacting conformation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

Crystal structure of the ligand-free G-protein-coupled receptor opsin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

An improved relaxed complex scheme for receptor flexibility in computer-aided drug design

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

Constitutive activity of muscarinic acetylcholine receptors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

Allosteric binding sites on cell-surface receptors: novel targets for drug discovery

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4012891

Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects.

21 June 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12233

Allosteric modulation of muscarinic acetylcholine receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12233

Computational drug design accommodating receptor flexibility: the relaxed complex scheme

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12233

The relaxed complex method: Accommodating receptor flexibility for drug design with an improved scoring scheme

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12233

Accelerated molecular dynamics: a promising and efficient simulation method for biomolecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12233

Measurement of the millisecond activation switch of G protein-coupled receptors in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12233

Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12233

Structural biology: Muscarinic receptors become crystal clear

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FCBDD.12233

21 January 2018

Identifiers

DOI

10.1111/CBDD.12233

1 reference

release_73pctavgzfhk3m4k7sbf7qllg4

28 July 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/73pctavgzfhk3m4k7sbf7qllg4

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMCID

4012891

1 reference

28 July 2017

1 reference

PubMed ID

24112716