Allosteric modulation of muscarinic acetylcholine receptors. (Q51755527)

11 April 2018

title

Allosteric modulation of muscarinic acetylcholine receptors. (English)

1 reference

11 April 2018

author

Patrick M. Sexton

series ordinal

2

1 reference

11 April 2018

author name string

Karen J Gregory

series ordinal

1

1 reference

11 April 2018

Arthur Christopoulos

series ordinal

3

1 reference

11 April 2018

publication date

1 September 2007

1 reference

11 April 2018

Current Neuropharmacology

published in

1 reference

11 April 2018

volume

5

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11 April 2018

issue

3

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11 April 2018

page(s)

157-167

1 reference

11 April 2018

Structural requirements of transmembrane domain 3 for activation by the M1 muscarinic receptor agonists AC-42, AC-260584, clozapine, and N-desmethylclozapine: evidence for three distinct modes of receptor activation

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Allosteric modulation of muscarinic receptor signaling: alcuronium-induced conversion of pilocarpine from an agonist into an antagonist

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Cholinergic dilation of cerebral blood vessels is abolished in M(5) muscarinic acetylcholine receptor knockout mice

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Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean.

22 May 2018

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Modes of allosteric interactions with free and [3H]N-methylscopolamine-occupied muscarinic M2 receptors as deduced from buffer-dependent potency shifts

22 May 2018

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Interactions of alcuronium, TMB-8, and other allosteric ligands with muscarinic acetylcholine receptors: studies with chimeric receptors.

22 May 2018

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22 May 2018

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Subtype-selective positive cooperative interactions between brucine analogs and acetylcholine at muscarinic receptors: functional studies

22 May 2018

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Muscarinic receptor subtypes involved in hippocampal circuits

22 May 2018

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Characterization of the subtype selectivity of the allosteric modulator heptane-1,7-bis-(dimethyl-3'-phthalimidopropyl) ammonium bromide (C7/3-phth) at cloned muscarinic acetylcholine receptors

22 May 2018

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Identification of a [3H]Ligand for the common allosteric site of muscarinic acetylcholine M2 receptors.

22 May 2018

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Allosteric interactions at muscarinic cholinoceptors

22 May 2018

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Subtype-selective positive cooperative interactions between brucine analogues and acetylcholine at muscarinic receptors: radioligand binding studies.

22 May 2018

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Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors

22 May 2018

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Three allosteric modulators act at a common site, distinct from that of competitive antagonists, at muscarinic acetylcholine M2 receptors.

22 May 2018

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Interactions of agonists with an allosteric antagonist at muscarinic acetylcholine M2 receptors

22 May 2018

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Opposite effects of alcuronium on agonist and on antagonist binding to muscarinic receptors

22 May 2018

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Two-point kinetic experiments to quantify allosteric effects on radioligand dissociation

22 May 2018

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Activation of muscarinic acetylcholine receptors via their allosteric binding sites.

22 May 2018

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Role of acidic amino acids in the allosteric modulation by gallamine of antagonist binding at the m2 muscarinic acetylcholine receptor

22 May 2018

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Mechanisms of steric and cooperative actions of alcuronium on cardiac muscarinic acetylcholine receptors

22 May 2018

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Use of chimeric muscarinic receptors to investigate epitopes involved in allosteric interactions.

22 May 2018

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Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetylcholine at muscarinic receptors.

22 May 2018

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Muscarinic receptors--characterization, coupling and function

22 May 2018

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The kinetics of competitive radioligand binding predicted by the law of mass action.

22 May 2018

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The effect of McN-A-343 on muscarinic receptors in the cerebral cortex and heart

22 May 2018

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Influence of ligand choice on the apparent binding profile of gallamine to cardiac muscarinic receptors. Identification of three main types of gallamine-muscarinic receptor interactions

22 May 2018

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Effects of tetrahydroaminoacridine on M1 and M2 muscarine receptors

22 May 2018

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Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods.

22 May 2018

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Expression of muscarinic acetylcholine and dopamine receptor mRNAs in rat basal ganglia

22 May 2018

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Localization of m5 muscarinic receptor mRNA in rat brain examined by in situ hybridization histochemistry.

22 May 2018

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Positive cooperativity in the binding of alcuronium and N-methylscopolamine to muscarinic acetylcholine receptors.

22 May 2018

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Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies

22 May 2018

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Muscarinic subtype selectivity of tetrahydroaminoacridine: Possible relationship to its capricious efficacy

22 May 2018

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22 May 2018

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The autoinhibitory feedback control of acetylcholine release in human neocortex tissue

22 May 2018

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The inhibitory effect of gallamine on muscarinic receptors

22 May 2018

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Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency

22 May 2018

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Interaction studies of multiple binding sites on m4 muscarinic acetylcholine receptors.

13 August 2018

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Design, synthesis, and action of oxotremorine-related hybrid-type allosteric modulators of muscarinic acetylcholine receptors

13 August 2018

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Opposing functions of spinal M2, M3, and M4 receptor subtypes in regulation of GABAergic inputs to dorsal horn neurons revealed by muscarinic receptor knockout mice

13 August 2018

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Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist

13 August 2018

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Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2/M5 chimeric receptors

13 August 2018

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Critical amino acid residues of the common allosteric site on the M2 muscarinic acetylcholine receptor: more similarities than differences between the structurally divergent agents gallamine and bis(ammonio)alkane-type hexamethylene-bis-[dimethyl-(3

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Quantitative analysis of binding parameters of [3H]N-methylscopolamine in central nervous system of muscarinic acetylcholine receptor knockout mice

13 August 2018

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Asparagine, valine, and threonine in the third extracellular loop of muscarinic receptor have essential roles in the positive cooperativity of strychnine-like allosteric modulators

13 August 2018

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Regulation of M2 muscarinic acetylcholine receptor expression and signaling by prolonged exposure to allosteric modulators

13 August 2018

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Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity

13 August 2018

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Application of a kinetic model to the apparently complex behavior of negative and positive allosteric modulators of muscarinic acetylcholine receptors

13 August 2018

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A model of the human M2 muscarinic acetylcholine receptor

13 August 2018

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Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors

13 August 2018

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Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-o

13 August 2018

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The muscarinic M1/M4 receptor agonist xanomeline exhibits antipsychotic-like activity in Cebus apella monkeys

13 August 2018

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Cooperative interactions at M2 muscarinic acetylcholine receptors: structure/activity relationships in stepwise shortened bispyridinium- and bis(ammonio)alkane-type allosteric modulators

13 August 2018

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Analogs of WIN 62,577 define a second allosteric site on muscarinic receptors

13 August 2018

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Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice

13 August 2018

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Substituted pentacyclic carbazolones as novel muscarinic allosteric agents: synthesis and structure-affinity and cooperativity relationships

13 August 2018

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Allosteric site on muscarinic acetylcholine receptors: a single amino acid in transmembrane region 7 is critical to the subtype selectivities of caracurine V derivatives and alkane-bisammonium ligands

13 August 2018

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Changes of cooperativity between N-methylscopolamine and allosteric modulators alcuronium and gallamine induced by mutations of external loops of muscarinic M(3) receptors

13 August 2018

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Hyperactivity and intact hippocampus-dependent learning in mice lacking the M1 muscarinic acetylcholine receptor.

13 August 2018

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The allosteric interaction of otenzepad (AF-DX 116) at muscarinic M2 receptors in guinea pig atria.

13 August 2018

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Modeling the functional effects of allosteric modulators at pharmacological receptors: an extension of the two-state model of receptor activation.

13 August 2018

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Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site

13 August 2018

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Pharmacological analysis of the mode of interaction of McN-A-343 at atrial muscarinic M2 receptors

13 August 2018

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Development of antisera selective for m4 and m5 muscarinic cholinergic receptors: distribution of m4 and m5 receptors in rat brain.

13 August 2018

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Binding of the muscarine receptor antagonist heptane-1,7-bis(dimethyl-3'-phthalimidopropyl)ammonium bromide at cholinoceptor sites.

13 August 2018

1 reference

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Assessment of the allosteric interactions of the bisquaternary heptane-1,7-bis(dimethyl-3'-phthalimidopropyl)ammonium bromide at M1 and M2 muscarine receptors

13 August 2018

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Potentiation by alcuronium of the antimuscarinic effect of N-methylscopolamine in guinea pig left atria

13 August 2018

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Competition between positive and negative allosteric effectors on muscarinic receptors.

13 August 2018

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Inhibition of the actions of carbachol and DFP on guinea pig isolated atria by alkane-bis-ammonium compounds

13 August 2018

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Tetrahydroaminoacridine and other allosteric antagonists of hippocampal M1 muscarine receptors.

13 August 2018

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Allosteric Modulation of G Protein–Coupled Receptors

13 August 2018

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An unusual type of sympathetic ganglionic stimulant

29 September 2018

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12 December 2020

Activation of solubilized G-proteins by muscarinic acetylcholine receptors

1 reference

12 December 2020

Site-directed mutagenesis reveals two epitopes involved in the subtype selectivity of the allosteric interactions of gallamine at muscarinic acetylcholine receptors

1 reference

12 December 2020

Expression of m1-m4 muscarinic acetylcholine receptor proteins in rat hippocampus and regulation by cholinergic innervation

1 reference

12 December 2020

Positive and negative allosteric interactions on muscarinic receptors

1 reference

12 December 2020

Competitive and allosteric interactions of 6-chloro-5,10-dihydro-5-[(1-methyl-4-piperidinyl)acetyl]-11H-di benzo[b,e][1, 4]diazepine-11-one hydrochloride (UH-AH 37) at muscarinic receptors, via distinct epitopes

1 reference

12 December 2020

The interaction of McN-A-343 with pirenzepine and other selective muscarine receptor antagonists at a prejunctional muscarine receptor

1 reference

12 December 2020

Probing of the location of the allosteric site on m1 muscarinic receptors by site-directed mutagenesis

1 reference

12 December 2020

Evidence for a multiple binding mode of bispyridinium-type allosteric modulators of muscarinic receptors

1 reference

12 December 2020

Subtype selectivity of the positive allosteric action of alcuronium at cloned M1-M5 muscarinic acetylcholine receptors

1 reference

12 December 2020

Identification of drugs competing with d-tubocurarine for an allosteric site on cardiac muscarinic receptors

1 reference

12 December 2020

Allosteric interactions with muscarinic acetylcholine receptors: complex role of the conserved tryptophan M2422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity

1 reference

12 December 2020

Heterogeneity of binding sites on cardiac muscarinic receptors induced by the neuromuscular blocking agents gallamine and pancuronium

1 reference

12 December 2020

Localization of a family of muscarinic receptor mRNAs in rat brain

1 reference

12 December 2020

Multiple in vitro interactions with and differential in vivo regulation of muscarinic receptor subtypes by tetrahydroaminoacridine

1 reference

12 December 2020

Divergent modes of action among cationic allosteric modulators of muscarinic M2 receptors

1 reference

12 December 2020

Two allosteric modulators interact at a common site on cardiac muscarinic receptors

1 reference

12 December 2020

Effects of d-tubocurarine on rat cardiac muscarinic receptors: a comparison with gallamine

1 reference

12 December 2020

Using a radioalloster to test predictions of the cooperativity model for gallamine binding to the allosteric site of muscarinic acetylcholine M(2) receptors

1 reference

12 December 2020

Positive allosteric action of eburnamonine on cardiac muscarinic acetylcholine receptors

1 reference

12 December 2020

Allosteric interactions at the m1, m2 and m3 muscarinic receptor subtypes

1 reference

12 December 2020

Effects of an agonist, allosteric modulator, and antagonist on guanosine-gamma-[35S]thiotriphosphate binding to liposomes with varying muscarinic receptor/Go protein stoichiometry

1 reference

12 December 2020

Modification of the binding properties of muscarinic receptors by gallamine

1 reference

12 December 2020

10.2174/157015907781695946

Identifiers

DOI

1 reference

11 April 2018

PMCID

2656816

1 reference

11 April 2018

PubMed ID

19305798

1 reference

11 April 2018