Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs (Q33572902)

28 July 2017

title

Effects of chemical modification on the potency, serum stability, and immunostimulatory properties of short shRNAs (English)

1 reference

28 July 2017

Brian H Johnston

6

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Mark A. Behlke

object named as

Mark A Behlke

5

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author name string

Qing Ge

1

1 reference

28 July 2017

Anne Dallas

2

1 reference

28 July 2017

Heini Ilves

3

1 reference

28 July 2017

Joshua Shorenstein

4

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28 July 2017

language of work or name

English

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publication date

30 November 2009

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28 July 2017

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28 July 2017

volume

16

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28 July 2017

issue

1

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28 July 2017

page(s)

118-130

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Minimal-length short hairpin RNAs: the relationship of structure and RNAi activity

28 July 2017

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21 June 2018

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21 June 2018

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Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing

21 June 2018

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21 June 2018

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21 June 2018

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Progress towards in vivo use of siRNAs

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Antisense technologies. Improvement through novel chemical modifications

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Substrate Specificity and Kinetics of Degradation of Antisense Oligonucleotides by a 3′ Exonuclease in Plasma

21 June 2018

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Interactions between double-stranded RNA regulators and the protein kinase DAI

21 June 2018

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Chemical modification of siRNAs to improve serum stability without loss of efficacy.

21 June 2018

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Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo

31 October 2018

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Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA.

31 October 2018

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Synthetic shRNAs as potent RNAi triggers.

31 October 2018

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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

31 October 2018

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RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.

31 October 2018

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Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3.

31 October 2018

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RNA interference in mammalian cells by chemically-modified RNA.

31 October 2018

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Toll-like receptors stimulate human neutrophil function

31 October 2018

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Gene Expression Analysis in Blood Cells in Response to Unmodified and 2′-Modified siRNAs Reveals TLR-dependent and Independent Effects

31 October 2018

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Chemical and Structural Diversity of siRNA Molecules

31 October 2018

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12 December 2020

Monocyte-derived dendritic cells from highly atopic individuals are not impaired in their pro-inflammatory response to toll-like receptor ligands

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12 December 2020

2'-O-methyl-modified RNAs act as TLR7 antagonists

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12 December 2020

Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA

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12 December 2020

Identifiers

DOI

10.1261/RNA.1901810

1 reference

28 July 2017

1 reference

28 July 2017

1 reference