Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex. (Q33569765)

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English	Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex.	scientific article

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11 February 2020

Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex (English)

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11 February 2020

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11 February 2020

author name string

Yaping Yu

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11 February 2020

Brandi L Mahaney

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11 February 2020

Brandon Cai

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11 February 2020

Ruiqiong Ye

5

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11 February 2020

Barry M Phipps

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11 February 2020

Robert P Rambo

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11 February 2020

Greg L Hura

8

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11 February 2020

Martin Pelikan

9

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11 February 2020

Sairei So

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11 February 2020

Ramin M Abolfath

11

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11 February 2020

David J Chen

12

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11 February 2020

Susan P Lees-Miller

13

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5 November 2009

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11 February 2020

Journal of Biological Chemistry

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11 February 2020

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11 February 2020

1414-1423

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11 February 2020

2

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11 February 2020

Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases

1 reference

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21 June 2018

Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair

1 reference

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21 June 2018

Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, Polynucleotide Kinase.

1 reference

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21 June 2018

The Structure and Conformation of Lys63-Linked Tetraubiquitin

1 reference

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21 June 2018

Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS)

1 reference

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21 June 2018

Structure and flexibility within proteins as identified through small angle X-ray scattering

1 reference

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21 June 2018

Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

1 reference

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21 June 2018

DNA-PK: the means to justify the ends?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801267

21 June 2018

Integration of small-angle X-ray scattering data into structural modeling of proteins and their assemblies

1 reference

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21 June 2018

A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801267

21 June 2018

Cryo-EM structure of the DNA-dependent protein kinase catalytic subunit at subnanometer resolution reveals alpha helices and insight into DNA binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801267

21 June 2018

The endless tale of non-homologous end-joining

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801267

21 June 2018

X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801267

21 June 2018

Ku recruits XLF to DNA double-strand breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801267

21 June 2018

Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

1 reference

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21 June 2018

Structural characterization of flexible proteins using small-angle X-ray scattering

1 reference

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21 June 2018

DNA double-strand break repair: from mechanistic understanding to cancer treatment

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21 June 2018

trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801267

21 June 2018

Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801267

21 June 2018

The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801267

21 June 2018

Terminal DNA structure and ATP influence binding parameters of the DNA-dependent protein kinase at an early step prior to DNA synapsis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801267

21 June 2018

The role of double-strand break repair — insights from human genetics

1 reference

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21 June 2018

Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801267

21 June 2018

The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis

1 reference

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21 June 2018

Global rigid body modeling of macromolecular complexes against small-angle scattering data

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21 June 2018

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

1 reference

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21 June 2018

Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks.

1 reference

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21 June 2018

Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs)

1 reference

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21 June 2018

Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends

1 reference

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21 June 2018

Structure and function of the double-strand break repair machinery.

1 reference

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21 June 2018

Analysis of binding reactions by fluorescence recovery after photobleaching

1 reference

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21 June 2018

The 3D solution structure of the C-terminal region of Ku86 (Ku86CTR)

1 reference

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21 June 2018

Visualization of DNA-induced conformational changes in the DNA repair kinase DNA-PKcs

1 reference

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21 June 2018

Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801267

21 June 2018

Subnuclear localization of Ku protein: functional association with RNA polymerase II elongation sites.

1 reference

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21 June 2018

Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

1 reference

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21 June 2018

Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase

1 reference

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21 June 2018

Synapsis of DNA ends by DNA-dependent protein kinase

1 reference

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21 June 2018

DNA double-strand break repair from head to tail

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21 June 2018

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801267

21 June 2018

The three-dimensional structure of the C-terminal DNA-binding domain of human Ku70

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801267

21 June 2018

Determination of domain structure of proteins from X-ray solution scattering

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801267

21 June 2018

Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801267

21 June 2018

Mapping of protein-protein interactions within the DNA-dependent protein kinase complex

1 reference

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21 June 2018

Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing

1 reference

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21 June 2018

The Fab and Fc fragments of IgA1 exhibit a different arrangement from that in IgG: a study by X-ray and neutron solution scattering and homology modelling

1 reference

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21 June 2018

Structure of DNA-dependent protein kinase: implications for its regulation by DNA.

1 reference

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21 June 2018

Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini

1 reference

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21 June 2018

Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies

1 reference

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21 June 2018

The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.065615

21 January 2018

Solution structure of the C-terminal domain of Ku80 suggests important sites for protein-protein interactions.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.065615

21 January 2018

Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).

1 reference

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21 January 2018

Cryo-EM imaging of the catalytic subunit of the DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.065615

21 January 2018

The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation

1 reference

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21 January 2018

Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair

2 references

https://api.crossref.org/works/10.1074%2FJBC.M109.065615

21 January 2018

https://pubmed.ncbi.nlm.nih.gov/19893054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-specific proteolytic cleavage of Ku protein bound to DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/19893054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/19893054

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.065615

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19893054%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19893054%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19893054%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

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