Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia (Q33558976)

28 July 2017

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia (English)

1 reference

28 July 2017

1 reference

acute myeloid leukemia

1 reference

21

Carsten Müller-Tidow

0 references

Kimberly Stegmaier

26

Kimberly Stegmaier

1 reference

28 July 2017

7

Gabriela Alexe

1 reference

28 July 2017

Federico Comoglio

3

0 references

Michael A Rieger

Michael A Rieger

18

0 references

Timm Schroeder

Timm Schroeder

19

0 references

Hubert Serve

Hubert Serve

28

0 references

Anthony R Green

Anthony R Green

24

0 references

Frank Schnütgen

12

Frank Schnütgen

1 reference

28 July 2017

25

Henning Urlaub

1 reference

28 July 2017

9

Philipp Ströbel

1 reference

28 July 2017

Sebastian Mohr

1

1 reference

28 July 2017

Carmen Doebele

2

1 reference

28 July 2017

Tobias Berg

4

1 reference

28 July 2017

Julia Beck

5

1 reference

28 July 2017

Hanibal Bohnenberger

6

1 reference

28 July 2017

Jasmin Corso

8

1 reference

28 July 2017

Astrid Wachter

10

1 reference

28 July 2017

Tim Beissbarth

11

1 reference

28 July 2017

Anjali Cremer

13

1 reference

28 July 2017

Nadine Haetscher

14

1 reference

28 July 2017

Stefanie Göllner

15

1 reference

28 July 2017

Arefeh Rouhi

16

1 reference

28 July 2017

Lars Palmqvist

17

1 reference

28 July 2017

Halvard Bönig

20

1 reference

28 July 2017

Florian Kuchenbauer

22

1 reference

28 July 2017

Ekkehard Schütz

23

1 reference

28 July 2017

R Keith Humphries

27

1 reference

28 July 2017

Thomas Oellerich

29

1 reference

28 July 2017

1 April 2017

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28 July 2017

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28 July 2017

31

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28 July 2017

4

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28 July 2017

549-562.e11

1 reference

describes a project that uses

28 July 2017

DESeq2

DESeq2

1 reference

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

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Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment

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Elucidation of tonic and activated B-cell receptor signaling in Burkitt's lymphoma provides insights into regulation of cell survival

14 July 2018

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Meis1 Is Required for Adult Mouse Erythropoiesis, Megakaryopoiesis and Hematopoietic Stem Cell Expansion

14 July 2018

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STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling

14 July 2018

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Minimal PU.1 reduction induces a preleukemic state and promotes development of acute myeloid leukemia.

14 July 2018

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Increased SYK activity is associated with unfavorable outcome among patients with acute myeloid leukemia

14 July 2018

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Predicting effective microRNA target sites in mammalian mRNAs

14 July 2018

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Orchestrating high-throughput genomic analysis with Bioconductor

14 July 2018

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FLT3-ITD and TLR9 use Bruton tyrosine kinase to activate distinct transcriptional programs mediating AML cell survival and proliferation.

14 July 2018

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Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells

14 July 2018

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Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

14 July 2018

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14 July 2018

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SYK is a critical regulator of FLT3 in acute myeloid leukemia

14 July 2018

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ISMARA: automated modeling of genomic signals as a democracy of regulatory motifs

14 July 2018

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PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway.

14 July 2018

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An optimized microRNA backbone for effective single-copy RNAi

14 July 2018

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In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling

14 July 2018

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Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia

14 July 2018

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SYK regulates mTOR signaling in AML.

14 July 2018

1 reference

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β2 integrin-derived signals induce cell survival and proliferation of AML blasts by activating a Syk/STAT signaling axis

14 July 2018

1 reference

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STAR: ultrafast universal RNA-seq aligner

14 July 2018

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An integrated encyclopedia of DNA elements in the human genome

14 July 2018

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Insights into the regulation of protein abundance from proteomic and transcriptomic analyses

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Fast gapped-read alignment with Bowtie 2

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Decoupling of tumor-initiating activity from stable immunophenotype in HoxA9-Meis1-driven AML.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

14 July 2018

ViennaRNA Package 2.0

1 reference

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Identification and characterization of Hoxa9 binding sites in hematopoietic cells

14 July 2018

1 reference

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The pathogenesis of mixed-lineage leukemia

14 July 2018

1 reference

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

14 July 2018

1 reference

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Cell of origin in AML: susceptibility to MN1-induced transformation is regulated by the MEIS1/AbdB-like HOX protein complex

14 July 2018

1 reference

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Macrophage development from HSCs requires PU.1-coordinated microRNA expression.

14 July 2018

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Comprehensive analysis of mammalian miRNA* species and their role in myeloid cells

14 July 2018

1 reference

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Global quantification of mammalian gene expression control

14 July 2018

1 reference

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miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice

14 July 2018

1 reference

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Andromeda: a peptide search engine integrated into the MaxQuant environment

14 July 2018

1 reference

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RNA-seq analysis of 2 closely related leukemia clones that differ in their self-renewal capacity.

14 July 2018

1 reference

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The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Autoinhibition and adapter function of Syk.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Proteomic and genetic approaches identify Syk as an AML target

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Hematopoietic cytokines can instruct lineage choice

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

In-depth characterization of the microRNA transcriptome in a leukemia progression model

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Model-based analysis of ChIP-Seq (MACS)

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Linkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

MLL translocations, histone modifications and leukaemia stem-cell development

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Hox genes in hematopoiesis and leukemogenesis.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Near-maximal expansions of hematopoietic stem cells in culture using NUP98-HOX fusions

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Flt3 is dispensable to the Hoxa9/Meis1 leukemogenic cooperation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Persistent transactivation by meis1 replaces hox function in myeloid leukemogenesis models: evidence for co-occupancy of meis1-pbx and hox-pbx complexes on promoters of leukemia-associated genes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Role of ITAM-containing adapter proteins and their receptors in the immune system and bone

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Effect of transcription-factor concentrations on leukemic stem cells.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Highly selective enrichment of phosphorylated peptides from peptide mixtures using titanium dioxide microcolumns.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Meis1 programs transcription of FLT3 and cancer stem cell character, using a mechanism that requires interaction with Pbx and a novel function of the Meis1 C-terminus

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Stop and go extraction tips for matrix-assisted laser desorption/ionization, nanoelectrospray, and LC/MS sample pretreatment in proteomics

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

MEIS1 and HOXA7 genes in human acute myeloid leukemia

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemias

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

The transcriptomic landscape and directed chemical interrogation of MLL-rearranged acute myeloid leukemias.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Modeling the functional heterogeneity of leukemia stem cells: role of STAT5 in leukemia stem cell self-renewal.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

The combined expression of HOXA4 and MEIS1 is an independent prognostic factor in patients with AML.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Prognostically useful gene-expression profiles in acute myeloid leukemia.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5389883

Quantitative HOX expression in chromosomally defined subsets of acute myelogenous leukemia

31 October 2018

1 reference

12 December 2020

Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny

1 reference

12 December 2020

Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1

1 reference

12 December 2020

Transplantable cell lines generated with NUP98-Hox fusion genes undergo leukemic progression by Meis1 independent of its binding to DNA

1 reference

12 December 2020

10.1016/J.CCELL.2017.03.001

Identifiers

DOI

1 reference

28 July 2017

1 reference

28 July 2017

1 reference