High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation (Q33523403)

27 July 2017

title

High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation (English)

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27 July 2017

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15

Eric M Reiman

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27 July 2017

David O Azorsa

1

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27 July 2017

RiLee H Robeson

2

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27 July 2017

Danielle Frost

3

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27 July 2017

Bessie Meec hoovet

4

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27 July 2017

Gillian R Brautigam

5

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27 July 2017

Chad Dickey

6

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27 July 2017

Christian Beaudry

7

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27 July 2017

Gargi D Basu

8

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27 July 2017

David R Holz

9

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27 July 2017

Joseph A Hernandez

10

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27 July 2017

Kristen M Bisanz

11

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27 July 2017

Leslie Gwinn

12

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27 July 2017

Andrew Grover

13

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27 July 2017

Joseph Rogers

14

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27 July 2017

Michael Hutton

16

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27 July 2017

Dietrich A Stephan

17

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27 July 2017

Spyro Mousses

18

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27 July 2017

Travis Dunckley

19

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27 July 2017

language of work or name

English

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publication date

12 January 2010

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27 July 2017

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27 July 2017

volume

11

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27 July 2017

page(s)

25

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https://scigraph.springernature.com/pub.10.1186/1471-2164-11-25

27 July 2017

exact match

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cites work

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21 June 2018

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DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease

21 June 2018

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A brief history of tau: the evolving view of the microtubule-associated protein tau in neurodegenerative diseases

21 June 2018

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The role of tau phosphorylation in the pathogenesis of Alzheimer's disease

21 June 2018

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The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease

21 June 2018

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Regulation of neuronal PKA signaling through AKAP targeting dynamics

21 June 2018

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GSK-3beta directly phosphorylates and activates MARK2/PAR-1.

21 June 2018

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Kinomics: methods for deciphering the kinome

21 June 2018

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Orchestration of synaptic plasticity through AKAP signaling complexes

21 June 2018

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The protein kinase complement of the human genome

21 June 2018

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21 June 2018

Tau, where are we now?

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Tau protein in normal and Alzheimer's disease brain: an update

21 June 2018

1 reference

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The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase

21 June 2018

1 reference

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alpha-synuclein binds to Tau and stimulates the protein kinase A-catalyzed tau phosphorylation of serine residues 262 and 356.

21 June 2018

1 reference

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Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820455

The regulatory Ser262 of microtubule-associated protein tau is phosphorylated by phosphorylase kinase

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820455

Tau protein is phosphorylated by cyclic AMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase II within its microtubule-binding domains at Ser-262 and Ser-356.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820455

Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules

21 June 2018

1 reference

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Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262

21 June 2018

1 reference

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Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology

21 June 2018

1 reference

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Developmentally regulated expression of specific tau sequences

21 June 2018

1 reference

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Phosphorylated tau protein is integrated into paired helical filaments in Alzheimer's disease.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820455

The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820455

Double stranded RNA activated EIF2 alpha kinase (EIF2AK2; PKR) is associated with Alzheimer's disease.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820455

Double-strand RNA dependent protein kinase (PKR) is involved in the extrastriatal degeneration in Parkinson's disease and Huntington's disease

31 October 2018

1 reference

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THE FINE STRUCTURE OF NEUROFIBRILLARY TANGLES IN ALZHEIMER'S DISEASE.

31 October 2018

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Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease

31 October 2018

1 reference

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Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820455

Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820455

Phosphorylation of microtubule-associated protein tau by Ca2+/calmodulin-dependent protein kinase II in its tubulin binding sites

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820455

Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease.

31 October 2018

1 reference

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Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles

31 October 2018

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Tau protein kinase I/GSK-3 beta/kinase FA in heparin phosphorylates tau on Ser199, Thr231, Ser235, Ser262, Ser369, and Ser400 sites phosphorylated in Alzheimer disease brain.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2820455

Calcium/calmodulin-dependent protein kinase II phosphorylates tau at Ser-262 but only partially inhibits its binding to microtubules

31 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20067632

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1471-2164-11-25

1 reference

Dimensions Publication ID

27 July 2017

1 reference

https://scigraph.springernature.com/pub.10.1186/1471-2164-11-25

9 September 2019

1 reference

27 July 2017

1 reference