RNA silencing of Mcl-1 enhances ABT-737-mediated apoptosis in melanoma: role for a caspase-8-dependent pathway (Q33494047)

27 July 2017

RNA silencing of Mcl-1 enhances ABT-737-mediated apoptosis in melanoma: role for a caspase-8-dependent pathway (English)

1 reference

27 July 2017

1 reference

Angela M Keuling

1

1 reference

27 July 2017

Kathleen E A Felton

2

1 reference

27 July 2017

Arabesque A M Parker

3

1 reference

27 July 2017

Majid Akbari

4

1 reference

27 July 2017

Susan E Andrew

5

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27 July 2017

Victor A Tron

6

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27 July 2017

language of work or name

English

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publication date

17 August 2009

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27 July 2017

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27 July 2017

4

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27 July 2017

8

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27 July 2017

e6651

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Creative Commons Attribution 4.0 International

27 July 2017

start time

17 August 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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BH3 mimetic ABT-737 and a proteasome inhibitor synergistically kill melanomas through Noxa-dependent apoptosis.

21 June 2018

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Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins

21 June 2018

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Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma

21 June 2018

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Treatment approaches for advanced cutaneous melanoma.

21 June 2018

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Systemic therapy for metastatic malignant melanoma--from deeply disappointing to bright future?

21 June 2018

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Overcoming apoptosis deficiency of melanoma-hope for new therapeutic approaches

21 June 2018

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BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

21 June 2018

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ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells.

21 June 2018

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Melanoma biology and new targeted therapy

21 June 2018

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Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737.

21 June 2018

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The Bcl-2 family protein inhibitor, ABT-737, has substantial antimyeloma activity and shows synergistic effect with dexamethasone and melphalan.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2722728

Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2722728

Involvement of caspase-8 in chemotherapy-induced apoptosis of patient derived leukemia cell lines independent of the death receptor pathway and downstream from mitochondria

21 June 2018

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

21 June 2018

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

21 June 2018

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Caspase-10 involvement in cytotoxic drug-induced apoptosis of tumor cells.

21 June 2018

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2722728

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2722728

Melanoma genetics and the development of rational therapeutics

21 June 2018

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Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis.

21 June 2018

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 June 2018

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Expression of the proapoptotic protein Bid is an adverse prognostic factor for radiotherapy outcome in carcinoma of the cervix.

21 June 2018

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Death receptors in chemotherapy and cancer

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2722728

DNA mismatch repair protein Msh6 is required for optimal levels of ultraviolet-B-induced apoptosis in primary mouse fibroblasts

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2722728

Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2722728

Association of Bax and Bak homo-oligomers in mitochondria. Bax requirement for Bak reorganization and cytochrome c release

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2722728

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 June 2018

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Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2722728

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2722728

Prognostic factors in 1,521 melanoma patients with distant metastases.

21 June 2018

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Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy.

21 June 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0006651

The role of Bcl-2 family members in the progression of cutaneous melanoma

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0006651

A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0006651

Involvement of the tumor necrosis factor (TNF)/TNF receptor system in leukemic cell apoptosis induced by histone deacetylase inhibitor depsipeptide (FK228).

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0006651

Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0006651

Bcl-2 family proteins are essential for platelet survival.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2722728

The statistics of synergism

31 October 2018

1 reference

12 December 2020

Expression of apoptosis regulators in cutaneous malignant melanoma

1 reference

12 December 2020

Mcl-1, Bcl-XL and Stat3 expression are associated with progression of melanoma whereas Bcl-2, AP-2 and MITF levels decrease during progression of melanoma

1 reference

12 December 2020

A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers

1 reference

12 December 2020

Myeloid leukemia-1 expression in benign and malignant melanocytic lesions

1 reference

12 December 2020

Antiapoptotic bcl-2 and bcl-xL in advanced malignant melanoma

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0006651

Identifiers

DOI

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27 July 2017

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27 July 2017

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