Decreased expression and promoter methylation of the menin tumor suppressor in pancreatic ductal adenocarcinoma. (Q33402990)

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20 January 2020

title

Decreased expression and promoter methylation of the menin tumor suppressor in pancreatic ductal adenocarcinoma (English)

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20 January 2020

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1

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20 January 2020

Micol Silic-Benussi

2

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20 January 2020

Annalisa Martines

4

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20 January 2020

Vincenzo Ciminale

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20 January 2020

author name string

Francesca Rende

3

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20 January 2020

Paola Fogar

5

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20 January 2020

Daniela Basso

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20 January 2020

Manuela Della Vella

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20 January 2020

Sergio Pedrazzoli

8

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20 January 2020

James G Herman

9

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20 January 2020

Luigi Chieco-Bianchi

10

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20 January 2020

Giovanni Esposito

11

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20 January 2020

Donna M D'Agostino

13

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publication date

1 May 2009

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Genes, Chromosomes and Cancer

20 January 2020

published in

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20 January 2020

volume

48

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20 January 2020

issue

5

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20 January 2020

page(s)

383-396

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Distribution of menin-occupied regions in chromatin specifies a broad role of menin in transcriptional regulation

20 January 2020

cites work

1 reference

7 January 2021

Menin molecular interactions: insights into normal functions and tumorigenesis.

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7 January 2021

Analysis of molecular pathways in sporadic neuroendocrine tumors of the gastro-entero-pancreatic system.

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7 January 2021

Menin and its interacting proteins: elucidation of menin function

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7 January 2021

Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type 1

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7 January 2021

In situ analysis of human menin in normal and neoplastic pancreatic tissues: evidence for differential expression in exocrine and endocrine cells

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A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors

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Global gene expression in neuroendocrine tumors from patients with the MEN1 syndrome

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Cancer biology. A matter of dosage

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Functional characterization of a promoter region in the human MEN1 tumor suppressor gene

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7 January 2021

Identifying molecular markers for the early detection of pancreatic neoplasia

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7 January 2021

Menin, the product of the MEN1 gene, is a nuclear protein

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7 January 2021

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands

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7 January 2021

Genetics and biology of pancreatic ductal adenocarcinoma.

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7 January 2021

Proliferation-associated expression of the MEN1 gene as revealed by in situ hybridization: possible role of the menin as a negative regulator of cell proliferation under DNA damage

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7 January 2021

Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c

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7 January 2021

Stable overexpression of MEN1 suppresses tumorigenicity of RAS.

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7 January 2021

Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1.

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7 January 2021

Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene

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7 January 2021

MethPrimer: designing primers for methylation PCRs

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7 January 2021

Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1

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7 January 2021

Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region.

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7 January 2021

Molecular genetics of multiple endocrine neoplasia types 1 and 2.

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7 January 2021

Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors

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7 January 2021

Global expression profiling of murine MEN1-associated tumors reveals a regulatory role for menin in transcription, cell cycle and chromatin remodelling.

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7 January 2021

Reduction of menin expression enhances cell proliferation and is tumorigenic in intestinal epithelial cells

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7 January 2021

Epigenetic alterations in intraductal papillary mucinous neoplasms of the pancreas

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7 January 2021

Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis

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7 January 2021

Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells

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7 January 2021

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression

1 reference

7 January 2021