Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter. (Q32133639)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9450972%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

title

Genetic separation of FK506 susceptibility and drug transport in the yeast Pdr5 ATP-binding cassette multidrug resistance transporter (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9450972%20AND%20SRC:MED&resulttype=core&format=json

ATP-binding cassette multidrug transporter PDR5 YOR153W

9 November 2019

main subject

multiple drug resistance

0 references

1 reference

GOA release 2020-03-11

author

Dominique Sanglard

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9450972%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

Karl Kuchler

5

1 reference

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9 November 2019

author name string

R Egner

1

1 reference

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9 November 2019

F E Rosenthal

2

1 reference

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9 November 2019

A Kralli

3

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9 November 2019

publication date

1 February 1998

1 reference

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Molecular Biology of the Cell

9 November 2019

language of work or name

1 reference

1 reference

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9 November 2019

volume

9

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9 November 2019

issue

2

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9 November 2019

page(s)

523-543

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Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene.

9 November 2019

cites work

1 reference

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21 June 2018

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Three amino acid substitutions selectively disrupt the activation but not the repression function of the glucocorticoid receptor N terminus.

21 June 2018

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MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine

21 June 2018

1 reference

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Sequence of 29 kb around the PDR10 locus on the right arm of Saccharomyces cerevisiae chromosome XV: similarity to part of chromosome I.

21 June 2018

1 reference

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Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors

21 June 2018

1 reference

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21 June 2018

1 reference

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The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo

21 June 2018

1 reference

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An FK506-sensitive transporter selectively decreases intracellular levels and potency of steroid hormones

21 June 2018

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Mutagenesis of transmembrane domain 11 of P-glycoprotein by alanine scanning

21 June 2018

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Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters

21 June 2018

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Altered drug-stimulated ATPase activity in mutants of the human multidrug resistance protein

21 June 2018

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Expression of an ATP-binding cassette transporter-encoding gene (YOR1) is required for oligomycin resistance in Saccharomyces cerevisiae

21 June 2018

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Gene SNQ2 of Saccharomyces cerevisiae, which confers resistance to 4-nitroquinoline-N-oxide and other chemicals, encodes a 169 kDa protein homologous to ATP-dependent permeases

21 June 2018

1 reference

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Prediction of protein secondary structure at better than 70% accuracy

21 June 2018

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Genetics and biochemistry of yeast multidrug resistance

21 June 2018

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Combining evolutionary information and neural networks to predict protein secondary structure

21 June 2018

1 reference

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Influence of a steroid receptor DNA-binding domain on transcriptional regulatory functions

21 June 2018

1 reference

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Mutations to amino acids located in predicted transmembrane segment 6 (TM6) modulate the activity and substrate specificity of human P-glycoprotein

21 June 2018

1 reference

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The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25282

Functional consequences of glycine mutations in the predicted cytoplasmic loops of P-glycoprotein

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25282

Functional evidence that transmembrane 12 and the loop between transmembrane 11 and 12 form part of the drug-binding domain in P-glycoprotein encoded by MDR1.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25282

Saccharomyces cerevisiae YDR1, which encodes a member of the ATP-binding cassette (ABC) superfamily, is required for multidrug resistance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25282

Membrane topology of a cysteine-less mutant of human P-glycoprotein

21 June 2018

1 reference

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LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones

21 June 2018

1 reference

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Cyclosporin A, FK506 and rapamycin: more than just immunosuppression

21 June 2018

1 reference

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The a-factor transporter (STE6 gene product) and cell polarity in the yeast Saccharomyces cerevisiae

21 June 2018

1 reference

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Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals

21 June 2018

1 reference

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Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae.

21 June 2018

1 reference

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Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity

21 June 2018

1 reference

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Degradation of CFTR by the ubiquitin-proteasome pathway

21 June 2018

1 reference

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A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus

21 June 2018

1 reference

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Analysis of membrane and surface protein sequences with the hydrophobic moment plot

21 June 2018

1 reference

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Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine

21 June 2018

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KAR1, a gene required for function of both intranuclear and extranuclear microtubules in yeast

21 June 2018

1 reference

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The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25282

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25282

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25282

Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25282

Phospholipid synthesis and lipid composition of subcellular membranes in the unicellular eukaryote Saccharomyces cerevisiae

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25282

Protein folding in the cell

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25282

A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25282

Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25282

Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25282

Amino acid substitutions in the sixth transmembrane domain of P-glycoprotein alter multidrug resistance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25282

ABC Transporters: From Microorganisms to Man

21 June 2018

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DNA sequencing with chain-terminating inhibitors

21 June 2018

1 reference

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Structure of the multidrug resistance P-glycoprotein to 2.5 nm resolution determined by electron microscopy and image analysis

21 June 2018

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The multidrug resistance-associated protein (MRP) subfamily (Yrs1/Yor1) of Saccharomyces cerevisiae is important for the tolerance to a broad range of organic anions

31 October 2018

1 reference

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Molecular cloning and expression of the Saccharomyces cerevisiae STS1 gene product. A yeast ABC transporter conferring mycotoxin resistance.

31 October 2018

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PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25282

Functional consequences of phenylalanine mutations in the predicted transmembrane domain of P-glycoprotein.

31 October 2018

1 reference

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Cystic fibrosis-type mutational analysis in the ATP-binding cassette transporter signature of human P-glycoprotein MDR1.

31 October 2018

1 reference

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Transmembrane aromatic amino acid distribution in P-glycoprotein. A functional role in broad substrate specificity

31 October 2018

1 reference

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Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=25282

Selective retention of secretory proteins in the yeast endoplasmic reticulum by treatment of cells with a reducing agent

31 October 2018

1 reference

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Functional dissection of P-glycoprotein nucleotide-binding domains in chimeric and mutant proteins. Modulation of drug resistance profiles

31 October 2018

1 reference

12 December 2020

Covalent inhibitors of P-glycoprotein ATPase activity

1 reference

12 December 2020

Direct demonstration of high affinity interactions of immunosuppressant drugs with the drug binding site of the human P-glycoprotein

1 reference

12 December 2020

Immunosuppressant Target Protein FKBP12 Is Required for P-Glycoprotein Function in Yeast

1 reference

12 December 2020

The ATP-binding cassette multidrug transporter Snq2 of Saccharomyces cerevisiae: a novel target for the transcription factors Pdr1 and Pdr3

1 reference

12 December 2020

Inhibition of Oxidative Cross-linking between Engineered Cysteine Residues at Positions 332 in Predicted Transmembrane Segments (TM) 6 and 975 in Predicted TM12 of Human P-glycoprotein by Drug Substrates

1 reference

12 December 2020

Anticancer drugs, ionophoric peptides, and steroids as substrates of the yeast multidrug transporter Pdr5p

1 reference

12 December 2020

Correction of Defective Protein Kinesis of Human P-glycoprotein Mutants by Substrates and Modulators

1 reference

12 December 2020

Identifiers

DOI

10.1091/MBC.9.2.523

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9450972%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9450972%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

PubMed publication ID

9450972

1 reference