Downregulation of MDM2 stabilizes p53 by inhibiting p53 ubiquitination in response to specific alkylating agents (Q32062474)

6 July 2017

Downregulation of MDM2 stabilizes p53 by inhibiting p53 ubiquitination in response to specific alkylating agents (English)

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6 July 2017

protein ubiquitination

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T Inoue

1

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6 July 2017

R K Geyer

series ordinal

2

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6 July 2017

Z K Yu

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3

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6 July 2017

C G Maki

series ordinal

4

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6 July 2017

language of work or name

English

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publication date

1 February 2001

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6 July 2017

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6 July 2017

490

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6 July 2017

3

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6 July 2017

196-201

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p53, the cellular gatekeeper for growth and division

6 July 2017

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https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

WAF1, a potential mediator of p53 tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

Regulation of p53 stability by Mdm2

21 January 2018

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https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

Mdm2 promotes the rapid degradation of p53

21 January 2018

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https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

The complexity of p53 modulation: emerging patterns from divergent signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

DNA damage induces phosphorylation of the amino terminus of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

Mdm2 association with p53 targets its ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

Characterization of sequence elements involved in p53 stability regulation reveals cell type dependence for p53 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

Regulation of p53 function and stability by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

Proteolysis by calpains: a possible contribution to degradation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

MDM2--master regulator of the p53 tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

The biology of alkylating-agent cellular injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

Overexpression of MDM2 protein in intrahepatic cholangiocarcinoma: relationship with p53 overexpression, Ki-67 labeling, and clinicopathological features

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-5793%2801%2902123-8

10.1016/S0014-5793(01)02123-8

7 January 2021

Identifiers

DOI

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6 July 2017

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