Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology. (Q30805627)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26921617%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

title

Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26921617%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

0 references

1 reference

0 references

6

1 reference

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9 March 2020

Brian West

7

1 reference

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9 March 2020

author name string

Elizabeth E Spangenberg

1

1 reference

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9 March 2020

Rafael J Lee

2

1 reference

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9 March 2020

Allison R Najafi

3

1 reference

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9 March 2020

Rachel A Rice

4

1 reference

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9 March 2020

Monica R P Elmore

5

1 reference

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9 March 2020

Kim N Green

8

1 reference

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9 March 2020

language of work or name

English

0 references

publication date

26 February 2016

1 reference

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9 March 2020

1 reference

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9 March 2020

volume

139

1 reference

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9 March 2020

issue

Pt 4

1 reference

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9 March 2020

page(s)

1265-1281

1 reference

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describes a project that uses

9 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5006229/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus.

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IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior.

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Microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function.

21 June 2018

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Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old

21 June 2018

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Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain.

21 June 2018

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Increased KIT inhibition enhances therapeutic efficacy in gastrointestinal stromal tumor

21 June 2018

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Identification of a unique TGF-β-dependent molecular and functional signature in microglia

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Inhibition of CSF-1 receptor improves the antitumor efficacy of adoptive cell transfer immunotherapy

21 June 2018

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CD2-associated protein regulates plasmacytoid dendritic cell migration, but is dispensable for their development and cytokine production.

21 June 2018

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CSF-1R inhibition alters macrophage polarization and blocks glioma progression

21 June 2018

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Synaptic deficits in layer 5 neurons precede overt structural decay in 5xFAD mice

21 June 2018

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Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice.

21 June 2018

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CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

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21 June 2018

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Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling

21 June 2018

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Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal β-catenin pathway function in an Alzheimer's disease model

21 June 2018

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21 June 2018

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Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

21 June 2018

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21 June 2018

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21 June 2018

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Genome-wide analysis of genetic loci associated with Alzheimer disease

21 June 2018

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CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice

21 June 2018

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Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

21 June 2018

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21 June 2018

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Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia

21 June 2018

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Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

21 June 2018

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Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals

21 June 2018

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Inflammation triggers synaptic alteration and degeneration in experimental autoimmune encephalomyelitis

21 June 2018

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Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model

21 June 2018

1 reference

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Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology

21 June 2018

1 reference

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Spatial relationship between synapse loss and beta-amyloid deposition in Tg2576 mice

21 June 2018

1 reference

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Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

21 June 2018

1 reference

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Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease

21 June 2018

1 reference

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Cytokines in neuroinflammation and Alzheimer's disease

21 June 2018

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Isolation and characterization of apolipoproteins from murine microglia. Identification of a low density lipoprotein-like apolipoprotein J-rich but E-poor spherical particle

21 June 2018

1 reference

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Cell mediators of inflammation in the Alzheimer disease brain

21 June 2018

1 reference

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Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signalin

21 June 2018

1 reference

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Complement component C1q modulates the phagocytosis of Abeta by microglia

21 June 2018

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Brain inflammation in Alzheimer disease and the therapeutic implications

21 June 2018

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Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease.

21 June 2018

1 reference

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Activation of microglial cells by beta-amyloid protein and interferon-gamma.

21 June 2018

1 reference

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The small pyramidal neuron of the rat cerebral cortex. The perikaryon, dendrites and spines

21 June 2018

1 reference

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Role of microglia in plaque formation in senile dementia of the Alzheimer type. An immunohistochemical study.

21 June 2018

1 reference

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Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques

21 June 2018

1 reference

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Elevated circulating tumor necrosis factor levels in Alzheimer's disease

21 June 2018

1 reference

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Astrocyte Depletion Impairs Redox Homeostasis and Triggers Neuronal Loss in the Adult CNS.

21 June 2018

1 reference

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Blockage of CR1 prevents activation of rodent microglia

25 November 2018

1 reference

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PPARγ/RXRα-induced and CD36-mediated microglial amyloid-β phagocytosis results in cognitive improvement in amyloid precursor protein/presenilin 1 mice.

25 November 2018

1 reference

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Motor deficits, neuron loss, and reduced anxiety coinciding with axonal degeneration and intraneuronal Aβ aggregation in the 5XFAD mouse model of Alzheimer's disease.

25 November 2018

1 reference

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Powerful beneficial effects of macrophage colony-stimulating factor on beta-amyloid deposition and cognitive impairment in Alzheimer's disease.

25 November 2018

1 reference

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Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment.

25 November 2018

1 reference

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Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006229

Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006229

Chronic brain inflammation results in cell loss in the entorhinal cortex and impaired LTP in perforant path-granule cell synapses

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006229

In-vivo measurement of activated microglia in dementia

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006229

Application of triple immunohistochemistry to characterize amyloid plaque-associated inflammation in brains with Alzheimer's disease.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006229

Microglia in cerebellar plaques in Alzheimer's disease

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006229

Long-term two-photon transcranial imaging of synaptic structures in the living brain

25 November 2018

1 reference

12 December 2020

Intrahippocampal LPS injections reduce Abeta load in APP+PS1 transgenic mice

1 reference

12 December 2020

Displacement of synaptic terminals from regenerating motoneurons by microglial cells

1 reference

12 December 2020

Estrogen enhances uptake of amyloid beta-protein by microglia derived from the human cortex

1 reference

12 December 2020

Identifiers

DOI

10.1093/BRAIN/AWW016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26921617%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26921617%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26921617%20AND%20SRC:MED&resulttype=core&format=json