The use of non-tumor data in cancer risk assessment: reflections on butadiene, vinyl chloride, and benzene (Q30781327)

26 June 2017

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title

The use of non-tumor data in cancer risk assessment: reflections on butadiene, vinyl chloride, and benzene (English)

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26 June 2017

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6

Julian Preston

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26 June 2017

2

Harvey Clewell

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26 June 2017

Richard Albertini

1

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26 June 2017

Matthew W Himmelstein

3

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26 June 2017

Eric Morinello

4

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26 June 2017

Stephen Olin

5

1 reference

26 June 2017

Louis Scarano

7

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26 June 2017

Martyn T Smith

8

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26 June 2017

James Swenberg

9

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26 June 2017

Raymond Tice

10

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26 June 2017

Curtis Travis

11

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26 June 2017

language of work or name

English

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publication date

1 February 2003

1 reference

Regulatory Toxicology and Pharmacology

26 June 2017

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26 June 2017

37

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26 June 2017

105-132

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26 June 2017

1

1 reference

Biomarkers for assessing occupational exposures to 1,3-butadiene

26 June 2017

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7 January 2021

Common themes in the pathogenesis of acute myeloid leukemia

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7 January 2021

Assessment of 1,3-butadiene exposure in polymer production workers using HPRT mutations in lymphocytes as a biomarker

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7 January 2021

A comparison of male-mediated effects in rats and mice exposed to 1,3-butadiene

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7 January 2021

Chromosome aberrations and response to gamma-ray challenge in lymphocytes of workers exposed to 1,3-butadiene

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7 January 2021

Carcinogens induce intrachromosomal recombination in human cells

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7 January 2021

Assessment of vinyl chloride-induced DNA damage in lymphocytes of plastic industry workers using a single-cell gel electrophoresis technique

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7 January 2021

Formation, detection, and role in carcinogenesis of ethenobases in DNA.

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7 January 2021

RAS and leukemia: from basic mechanisms to gene-directed therapy

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7 January 2021

Muconic acid determinations in urine as a biological exposure index for workers occupationally exposed to benzene

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7 January 2021

Biological markers of exposure to benzene: S-phenylcysteine in albumin

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7 January 2021

Biomarkers of human exposure to benzene

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7 January 2021

Species differences in urinary butadiene metabolites: comparisons of metabolite ratios between mice, rats, and humans

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7 January 2021

S-phenylcysteine in albumin as a benzene biomarker

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7 January 2021

Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group

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7 January 2021

Breath concentration as an index of the health risk from benzene. Studies on the accumulation and clearance of inhaled benzene.

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7 January 2021

Induction of sister chromatid exchange by 3,4-expoxybutane-1,2-diol in cultured human lymphocytes of different GSTT1 and GSTM1 genotypes

1 reference

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7 January 2021

Investigation of the DNA adducts formed in B6C3F1 mice treated with benzene: implications for molecular dosimetry

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7 January 2021

Red blood cell glycerol lysis and hematologic effects in occupational benzene exposure

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7 January 2021

Are chromosome aberrations in circulating lymphocytes predictive of future cancer onset in humans? Preliminary results of an Italian cohort study.

1 reference

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7 January 2021

Biological monitoring of exposure to benzene: a comparison between S-phenylmercapturic acid, trans,trans-muconic acid, and phenol

1 reference

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7 January 2021

Pharmacokinetics of vinyl chloride in the Rhesus monkey

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7 January 2021

Detection of endogenous malondialdehyde-deoxyguanosine adducts in human liver

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7 January 2021

Incorporation of biological information in cancer risk assessment: example--vinyl chloride

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7 January 2021

DNA adducts of 2,3-epoxy-4-hydroxynonanal: detection of 7-(1', 2'-dihydroxyheptyl)-3H-imidazo[2,1-i]purine and 1,N6-ethenoadenine by gas chromatography/negative ion chemical ionization/mass spectrometry

1 reference

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7 January 2021

The reaction of 3,4-epoxy-1-butene with deoxyguanosine and DNA in vitro: synthesis and characterization of the main adducts.

1 reference

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7 January 2021

Considering pharmacokinetic and mechanistic information in cancer risk assessments for environmental contaminants: examples with vinyl chloride and trichloroethylene.

1 reference

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7 January 2021

Mutagenicity of butadiene and its epoxide metabolites: I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-1,2-butanediol in cultured human lymphoblasts

1 reference

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7 January 2021

Evaluation of lymphopenia among workers with low-level benzene exposure and the utility of routine data collection

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Mortality, morbidity, and haematological results from a cohort of long-term workers involved in 1,3-butadiene monomer production

1 reference

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7 January 2021

Tissue distribution and macromolecular binding of extremely low doses of [14C]-benzene in B6C3F1 mice

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Comparison of the biotransformation of 1,3-butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

A follow-up study of synthetic rubber workers

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Genotoxic properties of 1,3-butadiene

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Mortality update of butadiene production workers

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https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Effects of exposure to vinyl chloride. An assessment of the evidence.

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Mortality among workers at a butadiene facility

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

trans,trans-Muconic acid, a reliable biological indicator for the detection of individual benzene exposure down to the ppm level.

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Human liver microsomes are efficient catalysts of 1,3-butadiene oxidation: evidence for major roles by cytochromes P450 2A6 and 2E1.

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Formation of 1,N6-ethenoadenine and 3,N4-ethenocytosine by lipid peroxidation products and nucleic acid bases

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Pharmacokinetics of ethylene in man; body burden with ethylene oxide and hydroxyethylation of hemoglobin due to endogenous and environmental ethylene

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Chromosome Changes and Their Evolution in Subjects With Past Exposure to Benzene

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Inter-individual variability of benzene metabolism to trans,trans-muconic acid and its implications in the biological monitoring of occupational exposure

1 reference

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7 January 2021

Roles of the vinyl chloride oxidation products 1-chlorooxirane and 2-chloroacetaldehyde in the in vitro formation of etheno adducts of nucleic acid bases [corrected]

1 reference

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7 January 2021

Mechanism of formation of ethenoguanine adducts from 2-haloacetaldehydes: 13C-labeling patterns with 2-bromoacetaldehyde

1 reference

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7 January 2021

Immunoaffinity/gas chromatography/high-resolution mass spectrometry method for the detection of N(2),3-ethenoguanine

1 reference

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7 January 2021

4-Hydroxy-2-nonenal and ethyl linoleate form N(2),3-ethenoguanine under peroxidizing conditions

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Benzene and the dose-related incidence of hematologic neoplasms in China. Chinese Academy of Preventive Medicine--National Cancer Institute Benzene Study Group.

1 reference

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7 January 2021

Genotoxic markers among butadiene polymer workers in China.

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Benzene and lymphohematopoietic malignancies in China

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Metabolism of 1,3-butadiene: species differences

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Toxicology and epidemiology of 1,3-butadiene

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Gasoline pump mechanics had increased frequencies and sizes of micronuclei in lymphocytes stimulated by pokeweed mitogen

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

p53 mutations at A:T base pairs in angiosarcomas of vinyl chloride-exposed factory workers

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Multiple organ carcinogenicity of 1,3-butadiene in B6C3F1 mice after 60 weeks of inhalation exposure.

1 reference

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7 January 2021

Susceptibility to 1,3-butadiene-induced leukemogenesis correlates with endogenous ecotropic retroviral background in the mouse

1 reference

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7 January 2021

Synergistic action of the benzene metabolite hydroquinone on myelopoietic stimulating activity of granulocyte/macrophage colony-stimulating factor in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

MutS recognition of exocyclic DNA adducts that are endogenous products of lipid oxidation

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https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Vinyl chloride: still a cause for concern

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Molecular dosimetry of N-7 guanine adduct formation in mice and rats exposed to 1,3-butadiene

1 reference

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7 January 2021

32P-postlabelling/HPLC assay reveals an enantioselective adduct formation in N7 guanine residues in vivo after 1,3-butadiene inhalation exposure.

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

DNA adducts in mouse testis and lung after inhalation exposure to 1,3-butadiene

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7 January 2021

Butadiene diolepoxide- and diepoxybutane-derived DNA adducts at N7-guanine: a high occurrence of diolepoxide-derived adducts in mouse lung after 1,3-butadiene exposure

1 reference

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7 January 2021

Tissue distribution of DNA adducts and their persistence in blood of mice exposed to benzene

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7 January 2021

Differential inhibition of DNA synthesis in human T cells by the cigarette tar components hydroquinone and catechol

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7 January 2021

Molecular analysis of hprt mutant lymphocytes from 1, 3-butadiene-exposed workers

1 reference

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7 January 2021

Carcinogenicity bioassays of vinyl chloride monomer: a model of risk assessment on an experimental basis

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7 January 2021

Carcinogenicity of vinyl chloride in Sprague-Dawley rats after prenatal and postnatal exposure.

1 reference

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7 January 2021

Activation of Ki-ras gene by point mutation in human liver angiosarcoma associated with vinyl chloride exposure

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7 January 2021

Environmental epidemiologic investigation of the styrene-butadiene rubber industry

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7 January 2021

Mutagenicity at the Hprt locus in T cells of female mice following inhalation exposures to low levels of 1,3-butadiene

1 reference

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7 January 2021

Genetic profile of acute myeloid leukemia

1 reference

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7 January 2021

Exhaled breath analysis as a measure of workplace exposure to benzene ppm

1 reference

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7 January 2021

Simultaneous quantitation of N(2),3-ethenoguanine and 1,N(2)-ethenoguanine with an immunoaffinity/gas chromatography/high-resolution mass spectrometry assay

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

1,N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytine in liver DNA from humans and untreated rodents detected by immunoaffinity/32P-postlabeling

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Hemoglobin adducts and urinary mercapturic acids in rats as biological indicators of butadiene exposure

1 reference

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7 January 2021

Inhalation toxicity studies with 1,3-butadiene. 3. Two year toxicity/carcinogenicity study in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Genetic effects of 1,3-butadiene and associated risk for heritable damage.

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

DNA adduct formation in the bone marrow of B6C3F1 mice treated with benzene

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Biological monitoring of occupational exposure to low levels of benzene

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Haemoglobin adducts of epoxybutanediol from exposure to 1,3-butadiene or butadiene epoxides

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

No increase in micronuclei frequency in cultured blood lymphocytes from a group of filling station attendants

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

1,N2-Propanodeoxyguanosine Adducts of the 1,3-Butadiene Metabolite, Hydroxymethylvinyl Ketone

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Mutagenic response to benzene and tris(2,3-dibromopropyl)-phosphate in the lambda lacI transgenic mouse mutation assay: a standardized approach to in vivo mutation analysis.

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

The use of protein adducts to investigate the disposition of reactive metabolites of benzene

1 reference

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7 January 2021

Benzene induces gene-duplicating but not gene-inactivating mutations at the glycophorin A locus in exposed humans

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Hematotoxicity among Chinese workers heavily exposed to benzene

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Bone marrow morphology in patients with neutropenia due to chronic exposure to organic solvents (benzene): early lesions

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Lymphohematopoietic cancer in styrene-butadiene polymerization workers

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Review of epidemiologic evidence on benzene and lymphatic and hematopoietic cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Carcinogens induce reversion of the mouse pink-eyed unstable mutation

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Species differences in the formation of butadiene monoxide from 1,3-butadiene

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Oxidation of 1,2-epoxy-3-butene to 1,2:3,4-diepoxybutane by cDNA-expressed human cytochromes P450 2E1 and 3A4 and human, mouse and rat liver microsomes

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

The mechanism of benzene-induced leukemia: a hypothesis and speculations on the causes of leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Report on the workshop entitled: "Modeling chemically induced leukemia--implications for benzene risk assessment"

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Molecular epidemiology of p53 protein mutations in workers exposed to vinyl chloride.

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Structural characterization of adducts formed in the reaction of 2,3-epoxy-4-hydroxynonanal with deoxyguanosine

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

IPCS conceptual framework for evaluating a mode of action for chemical carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Human cytogenetic biomonitoring of occupational exposure to 1,3-butadiene

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Assessment of exposure to butadiene in the process industry

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Chromosomal aberrations, sister-chromatid exchanges, cells with high frequency of SCE, micronuclei and comet assay parameters in 1, 3-butadiene-exposed workers

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Molecular cytogenetic analysis of buccal cells and lymphocytes from benzene-exposed workers.

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Using DNA and hemoglobin adducts to improve the risk assessment of butadiene

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Biological effect monitoring in industrial workers from the Czech Republic exposed to low levels of butadiene

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Relationship of chromosome 21 and acute leukemia in children with Down syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Monitoring of benzene-exposed workers for genotoxic effects of benzene: improved-working-condition-related decrease in the frequencies of chromosomal aberrations in peripheral blood lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Identification and quantitation of DNA adducts from calf thymus DNA exposed to 3,4-epoxy-1-butene

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Quantitative analysis of 1,3-butadiene-induced DNA adducts in vivo and in vitro using liquid chromatography electrospray ionization tandem mass spectrometry

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Influence of GSTM1 genotype on sister chromatid exchange induction by styrene-7,8-oxide and 1,2-epoxy-3-butene in cultured human lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

hprt mutant lymphocyte frequencies in workers at a 1,3-butadiene production plant

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Biological monitoring for mutagenic effects of occupational exposure to butadiene

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Risk of low red or white blood cell count related to estimated benzene exposure in a rubberworker cohort (1940-1975)

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Fate of [14C]vinyl chloride following inhalation exposure in rats

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Allelotyping of butadiene-induced lung and mammary adenocarcinomas of B6C3F1 mice: frequent losses of heterozygosity in regions homologous to human tumor-suppressor genes

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

The nature of chromosomal aberrations detected in humans exposed to benzene

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Human DNA adducts of 1,3-butadiene, an important environmental carcinogen

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

Molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases to 1-1.5 Mb and preparation of a PAC-based physical map.

1 reference

https://api.crossref.org/works/10.1016%2FS0273-2300%2802%2900019-3

7 January 2021

10.1016/S0273-2300(02)00019-3

Identifiers

DOI

1 reference

26 June 2017

1 reference