Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells (Q30570451)

20 August 2017

Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells (English)

1 reference

20 August 2017

E White

7

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author name string

J J Martino

1

1 reference

20 August 2017

B A Wall

2

1 reference

20 August 2017

E Mastrantoni

3

1 reference

20 August 2017

B J Wilimczyk

4

1 reference

20 August 2017

S N La Cava

5

1 reference

20 August 2017

K Degenhardt

6

1 reference

20 August 2017

S Chen

8

1 reference

20 August 2017

language of work or name

English

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publication date

22 October 2012

1 reference

20 August 2017

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20 August 2017

32

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20 August 2017

4366-4376

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20 August 2017

37

1 reference

Functional effects of GRM1 suppression in human melanoma cells

20 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Expression of the metabotropic glutamate receptor 5 (mGluR5) induces melanoma in transgenic mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Glutamatergic pathway targeting in melanoma: single-agent and combinatorial therapies

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Metabotropic glutamate receptor-1: a potential therapeutic target for the treatment of breast cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Akt signalling in health and disease.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Annual report to the nation on the status of cancer, 1975-2007, featuring tumors of the brain and other nervous system

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

G protein-coupled receptors: novel targets for drug discovery in cancer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

The glutamate release inhibitor Riluzole decreases migration, invasion, and proliferation of melanoma cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Pathological roles of MAPK signaling pathways in human diseases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Cancer cells release glutamate via the cystine/glutamate antiporter.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

AKT2 is a downstream target of metabotropic glutamate receptor 1 (Grm1).

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Cancer cell lines release glutamate into the extracellular environment.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

A phase 0 trial of riluzole in patients with resectable stage III and IV melanoma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Targeting glutamatergic signaling for the development of novel therapeutics for mood disorders

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Metabotropic glutamate receptors in the tripartite synapse as a target for new psychotropic drugs

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Metabotropic glutamate 1 receptor: current concepts and perspectives.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Metabotropic glutamate receptors (mGlus) and cellular transformation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

The potential role of Akt phosphorylation in human cancers

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Molecular insights and therapeutic targets in amyotrophic lateral sclerosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Metabotropic glutamate receptors in stem/progenitor cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Metabotropic glutamate receptors as drug targets

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Metabotropic glutamate receptor 1 and glutamate signaling in human melanoma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND)

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Nuclear localization of functional metabotropic glutamate receptor mGlu1 in HEK293 cells and cortical neurons: role in nuclear calcium mobilization and development

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

A mouse model system to genetically dissect the molecular mechanisms regulating tumorigenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Secretion of L-glutamate from osteoclasts through transcytosis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Insulin secretion is controlled by mGlu5 metabotropic glutamate receptors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Stimulation of oncogenic metabotropic glutamate receptor 1 in melanoma cells activates ERK1/2 via PKCepsilon

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

NMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growth

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Involvement of metabotropic glutamate receptor 1, a G protein coupled receptor, in melanoma development

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Establishment of conditional vectors for hairpin siRNA knockdowns

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

BAX and BAK mediate p53-independent suppression of tumorigenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Bax and Bak independently promote cytochrome C release from mitochondria

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Neurobiology. Receptors as kissing cousins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Glutamate as a neurotransmitter in the brain: review of physiology and pathology

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Glutamate: an amino acid of particular distinction

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Cloning of novel splice variants of mouse mGluR1.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Evidence for a novel glutamate-mediated signaling pathway in keratinocytes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Positive and negative coupling of the metabotropic glutamate receptors to a G protein-activated K+ channel, GIRK, in Xenopus oocytes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Changes in the carboxyl-terminal domain of metabotropic glutamate receptor 1 by alternative splicing generate receptors with differing agonist-independent activity.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Characterization of a highly invasive and spontaneously metastatic human malignant melanoma cell line

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Molecular and cellular characterization of human renal cell carcinoma cell lines

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3910169

Metabotropic glutamate receptors: new targets for the control of tumor growth?

20 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.471

Localization and function of group III metabotropic glutamate receptors in rat pancreatic islets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.471

Immunochemical localization of the metabotropic glutamate receptors in the rat heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.471

Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.471

Development of heritable melanoma in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.471

Glutamate receptors on human melanocytes regulate the expression of MiTF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.471

Global increases in kidney cancer incidence, 1973-1992.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.471

mGlu Receptors and Cancerous Growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.471

Pharmacological blockade of mGlu2/3 metabotropic glutamate receptors reduces cell proliferation in cultured human glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.471

Glutamate release promotes growth of malignant gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.471

Group-I metabotropic glutamate receptors, mGlu1a and mGlu5a, couple to extracellular signal-regulated kinase (ERK) activation via distinct, but overlapping, signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.471

In vivo pharmacodynamics of indole-3-carbinol in the inhibition of prostate cancer in transgenic adenocarcinoma of mouse prostate (TRAMP) mice: involvement of Nrf2 and cell cycle/apoptosis signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.471

Expression of functional mGlu5 metabotropic glutamate receptors in human melanocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.471

Selective blockade of mGlu5 metabotropic glutamate receptors protects rat hepatocytes against hypoxic damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.471

Risk of second primary malignancies in patients with cutaneous melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.471

Coexistence of renal cell carcinoma and malignant lymphoma. A causal relationship or coincidental occurrence?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.471

Progressive appearance of pigmentation in amelanotic melanoma lesions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.471

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.471

1 reference

Dimensions Publication ID

20 August 2017

0 references

1 reference

20 August 2017

1 reference