Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity (Q30493579)

13 September 2017

Mechanism of amyloid plaque formation suggests an intracellular basis of Abeta pathogenicity (English)

1 reference

13 September 2017

Ralf P Friedrich

1

1 reference

13 September 2017

Katharina Tepper

2

1 reference

13 September 2017

Raik Rönicke

3

1 reference

13 September 2017

Malle Soom

4

1 reference

13 September 2017

Martin Westermann

5

1 reference

13 September 2017

Klaus Reymann

6

1 reference

13 September 2017

Christoph Kaether

7

1 reference

13 September 2017

Marcus Fändrich

8

1 reference

13 September 2017

language of work or name

English

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publication date

19 January 2010

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13 September 2017

6

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Proceedings of the National Academy of Sciences of the United States of America

inferred from page(s)

published in

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13 September 2017

107

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13 September 2017

5

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13 September 2017

1942-1947

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Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

13 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Abeta(1-40) fibril polymorphism implies diverse interaction patterns in amyloid fibrils.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Structural classification of toxic amyloid oligomers

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Paired beta-sheet structure of an Abeta(1-40) amyloid fibril revealed by electron microscopy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Abeta42 mutants with different aggregation profiles induce distinct pathologies in Drosophila

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Directed selection of a conformational antibody domain that prevents mature amyloid fibril formation by stabilizing Abeta protofibrils

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Alzheimer disease models and human neuropathology: similarities and differences

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Autophagy, amyloidogenesis and Alzheimer disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Heat shock proteins and amateur chaperones in amyloid-Beta accumulation and clearance in Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Investigation into the role of macrophages in the formation and degradation of beta2-microglobulin amyloid fibrils

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

On the structural definition of amyloid fibrils and other polypeptide aggregates

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Biogenesis and function of multivesicular bodies

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Atomic structures of amyloid cross-beta spines reveal varied steric zippers

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

20 June 2018

Amyloid-beta aggregation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Polymorphism in the intermediates and products of amyloid assembly

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Protein misfolding, functional amyloid, and human disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

3D structure of Alzheimer's amyloid-beta(1-42) fibrils

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Amyloid: toward terminology clarification. Report from the Nomenclature Committee of the International Society of Amyloidosis.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Subcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Contribution of glial cells to the development of amyloid plaques in Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Therapeutic approaches to protein-misfolding diseases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Myoglobin forms amyloid fibrils by association of unfolded polypeptide segments

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Pathology, diagnosis and pathogenesis of AA amyloidosis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Intraneuronal Abeta42 accumulation in human brain.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Abeta1-42 pathogenesis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Kinetic theory of fibrillogenesis of amyloid beta-protein

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Beta-amyloid formation by myocytes of leptomeningeal vessels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Amyloid neuropathy: immunocytochemical localization of intra- and extracellular immunoglobulin light chains

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

The complex of microglial cells and amyloid star in three-dimensional reconstruction.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Image analysis microspectroscopy shows that neurons participate in the genesis of a subset of early primitive (diffuse) senile plaques

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Ultrastructural studies of the cells forming amyloid in the cortical vessel wall in Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

20 June 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0904532106

Extracellular amyloid formation and associated pathology in neural grafts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0904532106

Increased Abeta production leads to intracellular accumulation of Abeta in flotillin-1-positive endosomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0904532106

Alzheimer-like plaque formation by human macrophages is reduced by fibrillation inhibitors and lovastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0904532106

Thermodynamic analysis of the aggregation propensity of oxidized Alzheimer's beta-amyloid variants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0904532106

Mutagenic analysis of the nucleation propensity of oxidized Alzheimer's beta-amyloid peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0904532106

Internalization of beta-amyloid peptide by primary neurons in the absence of apolipoprotein E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0904532106

Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0904532106

Early intraneuronal Abeta deposition in the hippocampus of APP transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0904532106

Morphological and biochemical analyses of amyloid plaque core proteins purified from Alzheimer disease brain tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0904532106

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0904532106

Alternate aggregation pathways of the Alzheimer beta-amyloid peptide: Abeta association kinetics at endosomal pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0904532106

The effect of cholesterol and monosialoganglioside (GM1) on the release and aggregation of amyloid beta-peptide from liposomes prepared from brain membrane-like lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0904532106

Effect of different salt ions on the propensity of aggregation and on the structure of Alzheimer's abeta(1-40) amyloid fibrils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0904532106

Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2836607

Intracellular distribution of a biotin-labeled ganglioside, GM1, by immunoelectron microscopy after endocytosis in fibroblasts

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20133839

12 December 2020

inferred from PubMed ID database lookup

Interpreting the aggregation kinetics of amyloid peptides

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20133839

12 December 2020

inferred from PubMed ID database lookup

Apomyoglobin reveals a random-nucleation mechanism in amyloid protofibril formation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20133839

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.0904532106

1 reference

13 September 2017

0 references

1 reference

13 September 2017

1 reference