Investigation into the role of macrophages in the formation and degradation of beta2-microglobulin amyloid fibrils (Q40096568)

17 September 2017

Investigation into the role of macrophages in the formation and degradation of beta2-microglobulin amyloid fibrils (English)

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17 September 2017

3

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17 September 2017

Eric W Hewitt

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author name string

Isobel J Morten

series ordinal

1

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PubMed ID

17686767

17 September 2017

Walraj S Gosal

series ordinal

2

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PubMed ID

17686767

17 September 2017

language of work or name

English

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publication date

8 August 2007

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Journal of Biological Chemistry

17 September 2017

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17 September 2017

282

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17 September 2017

29691-29700

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17 September 2017

40

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Protein misfolding, functional amyloid, and human disease

17 September 2017

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

Serum levels of beta 2-microglobulin as a new form of amyloid protein in patients undergoing long-term hemodialysis.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

Mechanisms of MHC class I--restricted antigen processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

A systematic study of the effect of physiological factors on beta2-microglobulin amyloid formation at neutral pH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

Apolipoprotein E inhibits the depolymerization of beta 2-microglobulin-related amyloid fibrils at a neutral pH.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

Removal of the N-terminal hexapeptide from human beta2-microglobulin facilitates protein aggregation and fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

Unfolding, aggregation, and seeded amyloid formation of lysine-58-cleaved beta 2-microglobulin.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

Glycosaminoglycan and proteoglycan inhibit the depolymerization of beta2-microglobulin amyloid fibrils in vitro

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

Specific glycosaminoglycans promote unseeded amyloid formation from beta2-microglobulin under physiological conditions.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

A cell culture system for the study of amyloid pathogenesis. Amyloid formation by peritoneal macrophages cultured with recombinant serum amyloid A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

Amyloidogenesis recapitulated in cell culture: a peptide inhibitor provides direct evidence for the role of heparan sulfate and suggests a new treatment strategy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

Partially unfolded states of beta(2)-microglobulin and amyloid formation in vitro

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

Beta(2)-microglobulin and its deamidated variant, N17D form amyloid fibrils with a range of morphologies in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

A systematic investigation into the effect of protein destabilisation on beta 2-microglobulin amyloid formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

Competing pathways determine fibril morphology in the self-assembly of beta2-microglobulin into amyloid.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

Role of the N and C-terminal strands of beta 2-microglobulin in amyloid formation at neutral pH.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

Histological characteristics of sternoclavicular beta 2-microglobulin amyloidosis and clues for its histogenesis.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

Conformational Abs recognizing a generic amyloid fibril epitope

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

Quantifying amyloid by congo red spectral shift assay

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

Isolation and characterization of amyloid fibrils from tissue.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

Cellular uptake of beta2M and AGE-beta2M in synovial fibroblasts and macrophages

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

Phorbol ester induces elevated oxidative activity and alkalization in a subset of lysosomes

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

Stopped-flow kinetics reveal multiple phases of thioflavin T binding to Alzheimer beta (1-40) amyloid fibrils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

Hierarchical assembly of beta2-microglobulin amyloid in vitro revealed by atomic force microscopy.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

Amyloid formation under physiological conditions proceeds via a native-like folding intermediate.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

Role of the single disulphide bond of beta(2)-microglobulin in amyloidosis in vitro

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

The role of disulfide bond in the amyloidogenic state of beta(2)-microglobulin studied by heteronuclear NMR.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

Phagosome dynamics and function

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

myo-Inositol 1,4,5-trisphosphate and Ca(2+)/calmodulin-dependent factors mediate transduction of compression-induced signals in bovine articular chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

Proteomics of beta2-microglobulin amyloid fibrils.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705004200

The regions of the sequence most exposed to the solvent within the amyloidogenic state of a protein initiate the aggregation process.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

Slow degradation of aggregates of the Alzheimer's disease amyloid beta-protein by microglial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

Fibrillar islet amyloid polypeptide (amylin) is internalised by macrophages but resists proteolytic degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

beta 2-Microglobulin modified with advanced glycation end products is a major component of hemodialysis-associated amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

Involvement of beta 2-microglobulin modified with advanced glycation end products in the pathogenesis of hemodialysis-associated amyloidosis. Induction of human monocyte chemotaxis and macrophage secretion of tumor necrosis factor-alpha and interleu

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

Collagen plays an active role in the aggregation of beta2-microglobulin under physiopathological conditions of dialysis-related amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

Establishment of a kinetic model of dialysis-related amyloid fibril extensionin vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

Variants of β2-microglobulin cleaved at lysine-58 retain the main conformational features of the native protein but are more conformationally heterogeneous and unstable at physiological temperature

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

Thioflavine T interaction with amyloid β-sheet structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705004200

21 January 2018

Identifiers

DOI

10.1074/JBC.M705004200

1 reference

17 September 2017

1 reference

PubMed ID

17686767