Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice (Q30489530)

22 June 2017

Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice (English)

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22 June 2017

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James F Gusella

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22 June 2017

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Marcy E MacDonald

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22 June 2017

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Vanessa C Wheeler

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22 June 2017

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Seung Kwak

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22 June 2017

Vadim Alexandrov

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22 June 2017

Dani Brunner

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22 June 2017

Liliana B Menalled

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22 June 2017

Andrea Kudwa

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22 June 2017

Judy Watson-Johnson

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22 June 2017

Matthew Mazzella

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22 June 2017

Ian Russell

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22 June 2017

Melinda C Ruiz

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22 June 2017

Justin Torello

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22 June 2017

Emily Sabath

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22 June 2017

Ana Sanchez

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22 June 2017

Miguel Gomez

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22 June 2017

Igor Filipov

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22 June 2017

Kimberly Cox

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22 June 2017

Mei Kwan

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22 June 2017

Afshin Ghavami

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22 June 2017

Sylvie Ramboz

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22 June 2017

Brenda Lager

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22 June 2017

Jeff Aaronson

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22 June 2017

Jim Rosinski

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David Howland

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4 July 2016

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22 June 2017

838-844

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22 June 2017

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Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data

22 June 2017

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

21 January 2018

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CAG-repeat length and the age of onset in Huntington disease (HD): a review and validation study of statistical approaches

21 January 2018

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Mutation size and age at onset in Huntington's disease

21 January 2018

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Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function.

21 January 2018

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Studies on neurotransmitter markers and striatal neuronal cell density in Huntington's disease and dentatorubropallidoluysian atrophy

21 January 2018

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21 January 2018

Mouse ENU mutagenesis

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DRPLA transgenic mouse substrains carrying single copy of full-length mutant human DRPLA gene with variable sizes of expanded CAG repeats exhibit CAG repeat length- and age-dependent changes in behavioral abnormalities and gene expression profiles.

21 January 2018

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Behavioral signatures related to genetic disorders in autism

21 January 2018

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High-throughput analysis of behavior for drug discovery

21 January 2018

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Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice.

21 January 2018

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21 January 2018

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Huntington disease in a 9-year-old boy: clinical course and neuropathologic examination

21 January 2018

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21 January 2018

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Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats

21 January 2018

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Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175.

21 January 2018

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Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

21 January 2018

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CAG repeat lengths > or =335 attenuate the phenotype in the R6/2 Huntington's disease transgenic mouse

21 January 2018

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Early onset deficits on the delayed alternation task in the Hdh(Q92) knock-in mouse model of Huntington's disease.

21 January 2018

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Rule learning, visuospatial function and motor performance in the Hdh(Q92) knock-in mouse model of Huntington's disease.

21 January 2018

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Time course of choice reaction time deficits in the Hdh(Q92) knock-in mouse model of Huntington's disease in the operant serial implicit learning task (SILT).

21 January 2018

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Longitudinal analysis of the behavioural phenotype in HdhQ92 Huntington's disease knock-in mice

21 January 2018

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Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods

21 January 2018

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Rapid, computer vision-enabled murine screening system identifies neuropharmacological potential of two new mechanisms

21 January 2018

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Systemic administration of Congo red does not improve motor or cognitive function in R6/2 mice.

21 January 2018

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Comparative psychology and the grand challenge of drug discovery in psychiatry and neurodegeneration

21 January 2018

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Comprehensive behavioral testing in the R6/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline

21 January 2018

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A patient with Huntington's disease and long-surviving fetal neural transplants that developed mass lesions

21 January 2018

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Huntington's disease is a disorder of the corpus striatum: focus on Rhes (Ras homologue enriched in the striatum).

21 January 2018

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Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

21 January 2018

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A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

21 January 2018

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Endogenous kynurenines as targets for drug discovery and development

21 January 2018

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Human disease-drug network based on genomic expression profiles

21 January 2018

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Circadian Abnormalities in Motor Activity in a BAC Transgenic Mouse Model of Huntington's Disease

21 January 2018

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12 December 2020

A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease

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12 December 2020

Randomized controlled trial of ethyl-eicosapentaenoic acid in Huntington disease: the TREND-HD study

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12 December 2020

Cognitive deficits in transgenic and knock-in HTT mice parallel those in Huntington's disease

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12 December 2020

High-Throughput Automated Phenotyping of Two Genetic Mouse Models of Huntington's Disease

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12 December 2020

Multivariate assessment of locomotor behavior: pharmacological and behavioral analyses

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12 December 2020

A mixed fixed ratio/progressive ratio procedure reveals an apathy phenotype in the BAC HD and the z_Q175 KI mouse models of Huntington's disease

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12 December 2020

The rise and fall of Dimebon

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12 December 2020

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7 January 2021

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Identifiers

DOI

10.1038/NBT.3587

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22 June 2017

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