Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution (Q30479736)

12 October 2017

Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution (English)

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12 October 2017

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inferred from abstract

fitness landscape

1 reference

https://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-2-17#article-info

25 October 2022

binding site

object named as

Substrate Binding Pocket

1 reference

https://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-2-17#article-info

25 October 2022

Neutral network

1 reference

https://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-2-17#article-info

25 October 2022

genetic drift

object named as

Neutral Evolution

1 reference

https://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-2-17#article-info

25 October 2022

enzyme promiscuity

object named as

promiscuous protein functions

1 reference

inferred from abstract

adaptive evolution

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inferred from abstract

author

Jesse D. Bloom

series ordinal

1

1 reference

12 October 2017

4

Frances H Arnold

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12 October 2017

Philip A Romero

2

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12 October 2017

Zhongyi Lu

3

1 reference

12 October 2017

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28 June 2007

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12 October 2017

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12 October 2017

2

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12 October 2017

17

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Creative Commons Attribution 2.0 Generic

12 October 2017

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describes a project that uses

cytochrome P450

object of statement has role

scientific model

biological specimen

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directed evolution

object of statement has role

methodology

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peer review URL

https://biologydirect.biomedcentral.com/articles/10.1186/1745-6150-2-17#Sec14

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cites work

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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26 November 2018

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26 November 2018

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Direct conversion of ethane to ethanol by engineered cytochrome P450 BM3.

26 November 2018

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26 November 2018

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26 November 2018

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26 November 2018

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26 November 2018

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Exploring phenotype space through neutral evolution.

26 November 2018

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Step-wise mutation of barnase to binase. A procedure for engineering increased stability of proteins and an experimental analysis of the evolution of protein stability

26 November 2018

1 reference

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Molecular recognition in cytochrome P-450: mechanism for the control of uncoupling reactions.

26 November 2018

1 reference

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Continuity in evolution: on the nature of transitions

26 November 2018

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12 December 2020

In search of the limits of evolution

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12 December 2020

The catalytic mechanism of cytochrome P450 BM3 involves a 6 Å movement of the bound substrate on reduction

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12 December 2020

Are branched chain fatty acids the natural substrates for P450(BM3)?

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12 December 2020

Modelling neutral and selective evolution of protein folding

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12 December 2020

A continuous spectrophotometric assay for P450 BM-3, a fatty acid hydroxylating enzyme, and its mutant F87A

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12 December 2020

In vivo activation of zoxazolamine metabolism by flavone

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12 December 2020

Why are proteins marginally stable?

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12 December 2020

Evolutionary Divergence and Convergence in Proteins

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1186/1745-6150-2-17

Finite populations induce metastability in evolutionary search

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1186/1745-6150-2-17

Identifiers

DOI

10.1186/1745-6150-2-17

1 reference

Dimensions Publication ID

12 October 2017

1 reference

0 references

1 reference

PMC publication ID

1914045

12 October 2017

PubMed publication ID

17598905

1 reference

PMC publication ID

1914045