Gene therapy targeting leiomyoma: adenovirus-mediated delivery of dominant-negative estrogen receptor gene shrinks uterine tumors in Eker rat model (Q30477786)

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English	Gene therapy targeting leiomyoma: adenovirus-mediated delivery of dominant-negative estrogen receptor gene shrinks uterine tumors in Eker rat model	scientific article

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scholarly article

1 reference

Europe PubMed Central

12 October 2017

Gene therapy targeting leiomyoma: adenovirus-mediated delivery of dominant-negative estrogen receptor gene shrinks uterine tumors in Eker rat model (English)

1 reference

Europe PubMed Central

12 October 2017

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based on heuristic

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8

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Ayman Al-Hendy

1 reference

Europe PubMed Central

12 October 2017

author name string

Memy H Hassan

1

1 reference

Europe PubMed Central

12 October 2017

Salama A Salama

2

1 reference

Europe PubMed Central

12 October 2017

Dong Zhang

3

1 reference

Europe PubMed Central

12 October 2017

Hossam M M Arafa

4

1 reference

Europe PubMed Central

12 October 2017

Farid M A Hamada

5

1 reference

Europe PubMed Central

12 October 2017

Hala Fouad

6

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Europe PubMed Central

12 October 2017

Cheryl C Walker

7

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Europe PubMed Central

12 October 2017

language of work or name

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publication date

14 January 2009

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Europe PubMed Central

12 October 2017

Fertility and Sterility

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Europe PubMed Central

12 October 2017

93

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Europe PubMed Central

12 October 2017

239-250

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Europe PubMed Central

12 October 2017

1

1 reference

Europe PubMed Central

12 October 2017

Toward gene therapy of uterine fibroids: targeting modified adenovirus to human leiomyoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Leiomyomata uteri: hormonal and molecular determinants of growth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Progesterone regulates catechol-O-methyl transferase gene expression in breast cancer cells: distinct effect of progesterone receptor isoforms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Adenovirus-mediated delivery of a dominant-negative estrogen receptor gene in uterine leiomyoma cells abrogates estrogen- and progesterone-regulated gene expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Toward gene therapy of endometriosis: adenovirus-mediated delivery of dominant negative estrogen receptor genes inhibits cell proliferation, reduces cytokine production, and induces apoptosis of endometriotic cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Treatment of ovarian cancer with a novel dual targeted conditionally replicative adenovirus (CRAd).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Gene therapy of uterine leiomyoma: adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir treatment inhibits growth of human and rat leiomyoma cells in vitro and in a nude mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Clinical laboratory, virologic, and pathologic changes in hamsters experimentally infected with Pirital virus (Arenaviridae): a rodent model of Lassa fever.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Gene therapy and uterine leiomyoma: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Expanding treatment options for women with symptomatic uterine leiomyomas: timely medical breakthroughs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Uterine fibroids: the elephant in the room

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

The Eker rat: establishing a genetic paradigm linking renal cell carcinoma and uterine leiomyoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Gene therapy of uterine leiomyomas: adenovirus-mediated expression of dominant negative estrogen receptor inhibits tumor growth in nude mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Apoptosis - the p53 network

1 reference

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14 July 2018

Defining the actions of transforming growth factor beta in reproduction

1 reference

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14 July 2018

SOGC clinical guidelines. Hysterectomy.

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14 July 2018

Interactions of cytokines, growth factors, and the extracellular matrix in the cellular biology of uterine leiomyomata

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

p53AIP1 regulates the mitochondrial apoptotic pathway.

1 reference

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14 July 2018

Multiple roles of the tumor suppressor p53.

1 reference

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14 July 2018

A prospective controlled study of the effect of intramural uterine fibroids on the outcome of assisted conception

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14 July 2018

Dominant negative ER induces apoptosis in GH(4) pituitary lactotrope cells and inhibits tumor growth in nude mice.

1 reference

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14 July 2018

A new mathematical model for relative quantification in real-time RT-PCR

1 reference

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14 July 2018

Host responses and persistence of vector genome following intrabronchial administration of an E1(-)E3(-) adenovirus gene transfer vector to normal individuals

1 reference

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14 July 2018

Uterine leiomyomas: mechanisms of tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Uterine fibroids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Impact of intramural leiomyomata in patients with a normal endometrial cavity on in vitro fertilization-embryo transfer cycle outcome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Effects of progesterone on uterine leiomyoma growth and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Tumor volume measurements of acoustic neuromas with three-dimensional constructive interference in steady state and conventional spin-echo MR imaging.

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14 July 2018

CD95's deadly mission in the immune system

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14 July 2018

A cancer gene therapy approach utilizing an anti-erbB-2 single-chain antibody-encoding adenovirus (AD21): a phase I trial.

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14 July 2018

Targetable gene delivery vectors

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14 July 2018

Ovarian cancer gene therapy: repeated treatment with thymidine kinase in an adenovirus vector and ganciclovir improves survival in a novel immunocompetent murine model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Apaf1 and the apoptotic machinery

1 reference

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14 July 2018

Variability of human systemic humoral immune responses to adenovirus gene transfer vectors administered to different organs

1 reference

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14 July 2018

Maintenance of increased Bcl-2 expression in uterine leiomyomas after GnRH agonist therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

A visceral pain pathway in the dorsal column of the spinal cord

1 reference

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14 July 2018

Ordering the cytochrome c-initiated caspase cascade: hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner

1 reference

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14 July 2018

Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx

1 reference

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14 July 2018

Applying the herpes simplex virus thymidine kinase/ganciclovir approach to ovarian cancer: an effective in vitro drug-sensitization system

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14 July 2018

Leiomyoma-related bleeding: a classic hypothesis updated for the molecular era.

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14 July 2018

Apoptosis by death factor

1 reference

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14 July 2018

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

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14 July 2018

Established immunity precludes adenovirus-mediated gene transfer in rat carotid arteries. Potential for immunosuppression and vector engineering to overcome barriers of immunity

1 reference

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14 July 2018

Cyclin D1 is a nuclear protein required for cell cycle progression in G1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

The histopathology of uterine leiomyomas following treatment with gonadotropin-releasing hormone analogues

1 reference

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14 July 2018

Changing trends in treatment of leiomyomata uteri

1 reference

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14 July 2018

Bcl-2 blocks p53-dependent apoptosis

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14 July 2018

Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses

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14 July 2018

Progesterone: a critical role in the pathogenesis of uterine myomas

1 reference

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14 July 2018

Rodent model of reproductive tract leiomyomata. Clinical and pathological features

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Risk factors for uterine fibroids: reduced risk associated with oral contraceptives.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Therapeutic uses of gonadotropin-releasing hormone analogs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Expression of proliferating cell nuclear antigen (PCNA)/cyclin during the cell cycle

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Uterine insulin-like growth factor-1: regulation of expression and its role in estrogen-induced uterine proliferation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Cancer. p53, guardian of the genome

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

14 July 2018

Ethnic distribution of estrogen receptor-alpha polymorphism is associated with a higher prevalence of uterine leiomyomas in black Americans.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

26 November 2018

Soluble Fas, a mediator of apoptosis, C-reactive protein, and coronary and extracoronary atherosclerosis. The Rotterdam Coronary Calcification Study.

1 reference

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26 November 2018

Growth dynamics of human leiomyoma cells and inhibitory effects of the peroxisome proliferator-activated receptor-gamma ligand, pioglitazone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

26 November 2018

Serious complications of uterine artery embolization for conservative treatment of fibroids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

26 November 2018

p53 Tumor suppressor protein content in human uterine leiomyomas and its down-regulation by 17 beta-estradiol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

26 November 2018

Cell proliferation and apoptosis in human uterine leiomyomas and myometria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

26 November 2018

Down-regulation of proliferation and up-regulation of apoptosis by gonadotropin-releasing hormone agonist in cultured uterine leiomyoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

26 November 2018

MR microscopy of cobalt-labeled nerve cells and pathways in an invertebrate brain (Sepia officinalis, Cephalopoda).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

26 November 2018

Altered hormonal responsiveness of proliferation and apoptosis during myometrial maturation and the development of uterine leiomyomas in the rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

26 November 2018

Apoptotic cytosol facilitates Bax translocation to mitochondria that involves cytosolic factor regulated by Bcl-2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

26 November 2018

Adenovirus-mediated delivery of a dominant negative estrogen receptor gene abrogates estrogen-stimulated gene expression and breast cancer cell proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

26 November 2018

Bcl-2 family proteins and mitochondria.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

26 November 2018

Evidence for tight coupling of gonadotropin-releasing hormone receptor to stimulated Fas ligand expression in reproductive tract tumors: possible mechanism for hormonal control of apoptotic cell death.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

26 November 2018

Ornithine-delta-aminotransferase expression and ornithine metabolism in cultured epidermal keratinocytes: toward metabolic sink therapy for gyrate atrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2812608

26 November 2018

Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration.

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26 November 2018

Adenovirus mediated expression of therapeutic plasma levels of human factor IX in mice

1 reference

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26 November 2018

Long-acting gonadotropin hormone-releasing hormone analog used to treat uteri

1 reference

https://pubmed.ncbi.nlm.nih.gov/19144333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/19144333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitotic activity in uterine leiomyomas during the menstrual cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/19144333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Submucous myomas treated with gonadotropin releasing hormone agonist and resulting in vaginal hemorrhage. A case report

1 reference

https://pubmed.ncbi.nlm.nih.gov/19144333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Powerful dominant negative mutants of the human estrogen receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/19144333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progesterone receptor messenger ribonucleic acid and protein are overexpressed in human uterine leiomyomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/19144333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen receptor gene expression in human uterine leiomyomata

1 reference

https://pubmed.ncbi.nlm.nih.gov/19144333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of uterine leiomyomata on the results of in-vitro fertilization treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/19144333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reproductive Factors and Risk of Uterine Fibroids

1 reference

https://pubmed.ncbi.nlm.nih.gov/19144333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Abdominal myomectomy for infertility: a comprehensive review

1 reference

https://pubmed.ncbi.nlm.nih.gov/19144333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pregnancy outcome after laparoscopic electromyolysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19144333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of intramural, subserosal, and submucosal uterine fibroids on the outcome of assisted reproductive technology treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/19144333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogen receptors (ERalpha/ERbeta) in normal and pathological growth of the human myometrium: pregnancy and leiomyoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19144333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracoronary delivery of an adenovirus encoding fibroblast growth factor-4 in myocardial ischemia: effect of serum antibodies and previous exposure to adenovirus

1 reference

https://pubmed.ncbi.nlm.nih.gov/19144333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preclinical evidence for therapeutic efficacy of selective estrogen receptor modulators for uterine leiomyoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19144333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of Bcl-2, Bcl-x, Mcl-1, Bax and Bak in human uterine leiomyomas and myometrium during the menstrual cycle and after menopause

1 reference

https://pubmed.ncbi.nlm.nih.gov/19144333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Low-dose mifepristone for uterine leiomyomata

1 reference

https://pubmed.ncbi.nlm.nih.gov/19144333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene expression profile of leiomyoma and myometrium and the effect of gonadotropin releasing hormone analogue therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19144333

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.FERTNSTERT.2008.09.086

1 reference

Europe PubMed Central

12 October 2017

1 reference

Europe PubMed Central

12 October 2017

1 reference

Europe PubMed Central

12 October 2017

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