Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses (Q30465294)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

Rett syndrome mutation MeCP2 T158A disrupts DNA binding, protein stability and ERP responses (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

0 references

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Darren Goffin

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

author name string

Megan Allen

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Le Zhang

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Maria Amorim

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

I-Ting Judy Wang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Arith-Ruth S Reyes

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Amy Mercado-Berton

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Caroline Ong

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Sonia Cohen

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Linda Hu

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Julie A Blendy

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Gregory C Carlson

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Michael E Greenberg

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Zhaolan Zhou

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

language of work or name

English

0 references

publication date

27 November 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

page(s)

274-283

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

A role for glia in the progression of Rett's syndrome

17 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Gamma synchrony: towards a translational biomarker for the treatment-resistant symptoms of schizophrenia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Validating γ oscillations and delayed auditory responses as translational biomarkers of autism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

A new look at gamma? High- (>60 Hz) γ-band activity in cortical networks: function, mechanisms and impairment

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Dopamine-dependent tuning of striatal inhibitory synaptogenesis.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Abnormalities of cell packing density and dendritic complexity in the MeCP2 A140V mouse model of Rett syndrome/X-linked mental retardation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

MEG detection of delayed auditory evoked responses in autism spectrum disorders: towards an imaging biomarker for autism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Intact long-term potentiation but reduced connectivity between neocortical layer 5 pyramidal neurons in a mouse model of Rett syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

MeCP2, a key contributor to neurological disease, activates and represses transcription

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

MeCP2 binding to DNA depends upon hydration at methyl-CpG

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

The story of Rett syndrome: from clinic to neurobiology

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Reversal of neurological defects in a mouse model of Rett syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiology

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

High gamma power is phase-locked to theta oscillations in human neocortex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Neuronal oscillations in cortical networks

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Phenotypic manifestations of MECP2 mutations in classical and atypical Rett syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Oscillatory gamma activity in humans and its role in object representation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

DNA methylation specifies chromosomal localization of MeCP2.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Neurophysiological findings in the Rett syndrome, II: Visual and auditory brainstem, middle and late evoked responses.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267879

Mild overexpression of MeCP2 causes a progressive neurological disorder in mice.

28 July 2018

1 reference

Defective body-weight regulation, motor control and abnormal social interactions in Mecp2 hypomorphic mice.

21 January 2018

1 reference

Abnormal neural oscillations and synchrony in schizophrenia

21 January 2018

1 reference

Alterations of cortical and hippocampal EEG activity in MeCP2-deficient mice.

21 January 2018

1 reference

The development of visual- and auditory processing in Rett syndrome: an ERP study.

21 January 2018

1 reference

MECP2 gene mutation analysis in the British and Italian Rett Syndrome patients: hot spot map of the most recurrent mutations and bioinformatic analysis of a new MECP2 conserved region.

21 January 2018

1 reference

Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation

21 January 2018

1 reference

Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state.

21 January 2018

1 reference

Developing networks play a similar melody

21 January 2018

1 reference

Modular patterning of structure and function of the striatum by retinoid receptor signaling

21 January 2018

1 reference

A hearing and vestibular phenotyping pipeline to identify mouse mutants with hearing impairment

21 January 2018

1 reference

Schizophrenia: reduced signal-to-noise ratio and impaired phase-locking during information processing

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22119903

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Neuropathology of Rett syndrome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22119903

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pharmacological rescue of mutant p53 conformation and function

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22119903

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NN.2997

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22119903%20AND%20SRC:MED&resulttype=core&format=json