Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling. (Q30378420)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26310622%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

title

Synonymous variants in HTRA1 implicated in AMD susceptibility impair its capacity to regulate TGF-β signaling (English)

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22 February 2020

3

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22 February 2020

Felix Grassmann

6

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22 February 2020

Rudolf Fuchshofer

7

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22 February 2020

Gernot Längst

9

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22 February 2020

Bernhard H Weber

10

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22 February 2020

author name string

Ulrike Friedrich

1

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22 February 2020

Shyamtanu Datta

2

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22 February 2020

Karolina Plössl

4

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22 February 2020

Magdalena Schneider

5

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22 February 2020

Klaus-Jürgen Tiefenbach

8

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22 February 2020

publication date

26 August 2015

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22 February 2020

published in

Human Molecular Genetics

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22 February 2020

volume

24

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22 February 2020

page(s)

6361-6373

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22 February 2020

issue

22

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Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ

22 February 2020

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Serine protease HTRA1 antagonizes transforming growth factor-β signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer

21 January 2018

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21 January 2018

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Down-regulation of HtrA1 activates the epithelial-mesenchymal transition and ATM DNA damage response pathways

21 January 2018

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Two novel HTRA1 mutations in a European CARASIL patient

21 January 2018

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A novel mutation of the high-temperature requirement A serine peptidase 1 (HTRA1) gene in a Chinese family with cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL).

21 January 2018

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A missense HTRA1 mutation expands CARASIL syndrome to the Caucasian population

21 January 2018

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A novel mutation in the HTRA1 gene identified in Chinese CARASIL pedigree.

21 January 2018

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HTRA1 promoter polymorphism in wet age-related macular degeneration

21 January 2018

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Seven new loci associated with age-related macular degeneration

21 January 2018

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Alleles in the HtrA serine peptidase 1 gene alter the risk of neovascular age-related macular degeneration

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications

21 January 2018

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Hairpin structure of a biarsenical-tetracysteine motif determined by NMR spectroscopy

21 January 2018

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Determining protein stability in cell lysates by pulse proteolysis and Western blotting

21 January 2018

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A "silent" polymorphism in the MDR1 gene changes substrate specificity

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor

21 January 2018

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Rare codons regulate KRas oncogenesis

21 January 2018

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Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure.

21 January 2018

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21 January 2018

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21 January 2018

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Binding properties of insulin-like growth factor binding protein-3 (IGFBP-3), IGFBP-3 N- and C-terminal fragments, and structurally related proteins mac25 and connective tissue growth factor measured using a biosensor

21 January 2018

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Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity

21 January 2018

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Identification of urinary biomarkers for age-related macular degeneration

21 January 2018

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Polyethylene glycol (PEG)-induced mouse model of choroidal neovascularization

21 January 2018

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NBHA reduces acrolein-induced changes in ARPE-19 cells: possible involvement of TGFβ.

21 January 2018

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Subtoxic oxidative stress induces senescence in retinal pigment epithelial cells via TGF-beta release

21 January 2018

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21 January 2018

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Microglia: The constant gardeners.

21 January 2018

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Microglia: a sensor for pathological events in the CNS

21 January 2018

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Microglia: gatekeepers of central nervous system immunology.

21 January 2018

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The complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's disease

21 January 2018

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Inflammation, apoptosis, and Alzheimer's disease

21 January 2018

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The microglial phagocytic role with specific plaque types in the Alzheimer disease brain

21 January 2018

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Neuroinflammation in Alzheimer's disease; A source of heterogeneity and target for personalized therapy

21 January 2018

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What happens to microglial TREM2 in Alzheimer's disease: Immunoregulatory turned into immunopathogenic?

21 January 2018

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Microglial degeneration in the aging brain--bad news for neurons?

21 January 2018

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Microglia activation in retinal degeneration

21 January 2018

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Gene expression changes in aging retinal microglia: relationship to microglial support functions and regulation of activation

21 January 2018

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A2E accumulation influences retinal microglial activation and complement regulation

21 January 2018

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Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation

21 January 2018

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21 January 2018

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Microglia in the aging retina

21 January 2018

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Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice

21 January 2018

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TGF-beta1 blockade of microglial chemotaxis toward Abeta aggregates involves SMAD signaling and down-regulation of CCL5

21 January 2018

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TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation

21 January 2018

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21 January 2018

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Risk- and non-risk-associated variants at the 10q26 AMD locus influence ARMS2 mRNA expression but exclude pathogenic effects due to protein deficiency.

21 January 2018

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An integrated map of genetic variation from 1,092 human genomes

21 January 2018

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A Candidate Gene Association Study Identifies DAPL1 as a Female-Specific Susceptibility Locus for Age-Related Macular Degeneration (AMD).

21 January 2018

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Docosahexaenoic acid attenuates microglial activation and delays early retinal degeneration.

21 January 2018

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

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The novel activated microglia/macrophage WAP domain protein, AMWAP, acts as a counter-regulator of proinflammatory response

21 January 2018

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21 January 2018

Identifiers

DOI

10.1093/HMG/DDV346

1 reference

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22 February 2020

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