A2E accumulation influences retinal microglial activation and complement regulation (Q36346763)

13 August 2017

A2E accumulation influences retinal microglial activation and complement regulation (English)

1 reference

N-retinylidene-N-retinylethanolamine

13 August 2017

0 references

1 reference

ChEBI release 2020-05-28

5

1 reference

13 August 2017

1

Wenxin Ma

1 reference

13 August 2017

3

Lian Zhao

1 reference

13 August 2017

Steven Coon

2

1 reference

PMCID

3480997

13 August 2017

Robert N Fariss

series ordinal

4

1 reference

13 August 2017

20 July 2012

1 reference

13 August 2017

Neurobiology of Aging

1 reference

13 August 2017

34

1 reference

13 August 2017

3

1 reference

13 August 2017

943-960

1 reference

PMCID

3480997

describes a project that uses

13 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3480997/fullTextXML

inferred from PubMed Central ID database lookup

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3480997/fullTextXML

inferred from PubMed Central ID database lookup

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Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration

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Complement system dysregulation and inflammation in the retinal pigment epithelium of a mouse model for Stargardt macular degeneration

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CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axes and their possible involvement in age-related macular degeneration

30 September 2017

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Pathway-based therapies for age-related macular degeneration: an integrated survey of emerging treatment alternatives

30 September 2017

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Fundus autofluorescence and the bisretinoids of retina

30 September 2017

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Decay accelerating factor (CD55)-mediated attenuation of complement: therapeutic implications for age-related macular degeneration

30 September 2017

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Microglia in the healthy and degenerating retina: insights from novel mouse models

30 September 2017

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The role of complement Factor H in age-related macular degeneration: a review.

30 September 2017

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Complement, age-related macular degeneration and a vision of the future

30 September 2017

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Assessing activation states in microglia

30 September 2017

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Aging-dependent changes of microglial cells and their relevance for neurodegenerative disorders

30 September 2017

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Microglial involvement in neuroplastic changes following focal brain ischemia in rats

30 September 2017

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Microglia in the mouse retina alter the structure and function of retinal pigmented epithelial cells: a potential cellular interaction relevant to AMD.

30 September 2017

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The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages.

30 September 2017

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Para-inflammation in the aging retina.

30 September 2017

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Inflammation and the pathogenesis of age-related macular degeneration.

30 September 2017

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Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration

30 September 2017

1 reference

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Unraveling a multifactorial late-onset disease: from genetic susceptibility to disease mechanisms for age-related macular degeneration

30 September 2017

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Complement activation by bisretinoid constituents of RPE lipofuscin

30 September 2017

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Sub-retinal drusenoid deposits in human retina: organization and composition

30 September 2017

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Systemic complement activation in age-related macular degeneration

30 September 2017

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Neuron-microglia signaling: chemokines as versatile messengers.

30 September 2017

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Evaluation of adenovirus-delivered human CD59 as a potential therapy for AMD in a model of human membrane attack complex formation on murine RPE.

30 September 2017

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Direct multiplexed measurement of gene expression with color-coded probe pairs

30 September 2017

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Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice

30 September 2017

1 reference

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CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.

30 September 2017

1 reference

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Chemokines and chemokine receptors: multipurpose players in neuroinflammation.

30 September 2017

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Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Translocation of the retinal pigment epithelium and formation of sub-retinal pigment epithelium deposit induced by subretinal deposit

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

The role of inflammation in the pathogenesis of age-related macular degeneration

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

RPE lipofuscin and its role in retinal pathobiology

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

The chemokine system in diverse forms of macrophage activation and polarization

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Prevalence of age-related macular degeneration in the United States

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

A2E: a component of ocular lipofuscin

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Distribution, markers, and functions of retinal microglia

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Microglia-Müller glia cell interactions control neurotrophic factor production during light-induced retinal degeneration.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Sensitivity of photoreceptor-derived cell line (661W) to baculoviral p35, Z-VAD.FMK, and Fas-associated death domain

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

A role for local inflammation in the formation of drusen in the aging eye.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Risk factors for age-related macular degeneration: an update

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Complement activation and inflammatory processes in Drusen formation and age related macular degeneration

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Immunological and aetiological aspects of macular degeneration

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture.

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Neuroprotective function for ramified microglia in hippocampal excitotoxicity

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Up-regulation of complement factor B in retinal pigment epithelial cells is accompanied by complement activation in the aged retina

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Analysis of complement expression in light-induced retinal degeneration: synthesis and deposition of C3 by microglia/macrophages is associated with focal photoreceptor degeneration.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Complement deposition and microglial activation in the outer retina in light-induced retinopathy: inhibition by a 5-HT1A agonist.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Reticular pseudodrusen are subretinal drusenoid deposits

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Amyloid-beta up-regulates complement factor B in retinal pigment epithelial cells through cytokines released from recruited macrophages/microglia: Another mechanism of complement activation in age-related macular degeneration

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Role of the chemokine receptor CX3CR1 in the mobilization of phagocytic retinal microglial cells

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Causes and prevalence of visual impairment among adults in the United States

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Activated microglia in human retinitis pigmentosa, late-onset retinal degeneration, and age-related macular degeneration

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Light-induced migration of retinal microglia into the subretinal space

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Inhibition of RPE lysosomal and antioxidant activity by the age pigment lipofuscin.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Co-culture with astrocytes or microglia protects metabolically impaired neurons

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Blue light-induced apoptosis of A2E-containing RPE: involvement of caspase-3 and protection by Bcl-2.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Microglial cells prevent nitric oxide-induced neuronal apoptosis in vitro

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Inflammation in the pathogenesis of age-related macular degeneration

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3480997

Retinal age pigments generated by self-assembling lysosomotropic detergents

5 December 2018

1 reference

12 December 2020

Inhibition of lysosomal degradative functions in RPE cells by a retinoid component of lipofuscin

1 reference

12 December 2020

Oxidative stress modulates complement factor H expression in retinal pigmented epithelial cells by acetylation of FOXO3

1 reference

12 December 2020

Photodamage to human RPE cells by A2-E, a retinoid component of lipofuscin

1 reference

12 December 2020

Embryonic and postnatal development of microglial cells in the mouse retina

1 reference

12 December 2020

Age-related macular degeneration

1 reference

12 December 2020

10.1016/J.NEUROBIOLAGING.2012.06.010

Identifiers

DOI

1 reference

13 August 2017

1 reference

13 August 2017

1 reference

PMCID

3480997