Constraining cyclic peptides to mimic protein structure motifs. (Q30367509)

21 June 2017

1 reference

title

Constraining cyclic peptides to mimic protein structure motifs. (English)

1 reference

21 June 2017

2

Nicholas E Shepherd

1 reference

21 June 2017

Timothy A Hill

1

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Frederik Diness

object named as

Frederik Diness

series ordinal

3

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David P. Fairlie

object named as

David P Fairlie

series ordinal

4

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language of work or name

English

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publication date

6 October 2014

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Angewandte Chemie International Edition

21 June 2017

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volume

53

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21 June 2017

48

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21 June 2017

13020-13041

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

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The exploration of macrocycles for drug discovery--an underexploited structural class

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Protein epitope mimetics as anti-infectives

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The future of peptide-based drugs

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Emerging approaches in the molecular design of receptor-selective peptide ligands: conformational, topographical and dynamic considerations

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Design of beta-turn based therapeutic agents

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Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201401058

21 January 2018

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Update 1 of: Beta-strand mimetics.

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https://api.crossref.org/works/10.1002%2FANIE.201401058

Highly ordered structures of peptides by using molecular scaffolds

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Exploring beta-sheet structure and interactions with chemical model systems

21 January 2018

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The supramolecular chemistry of β-sheets

21 January 2018

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The synthesis and study of side-chain lactam-bridged peptides

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A Cyclic Metallopeptide Induces α Helicity in Short Peptide Fragments of Thermolysin

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Consecutive Cyclic Pentapeptide Modules Form Shortα-Helices that are Very Stable to Water and Denaturants

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Stapled peptides for intracellular drug targets

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Theory of the Phase Transition between Helix and Random Coil in Polypeptide Chains

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The mechanism of alpha-helix formation by peptides

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Defining solution conformations of small linear peptides

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https://api.crossref.org/works/10.1002%2FANIE.201401058

Predicting the biologically active conformations of short polypeptides

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Targeting HIV-1 protease: a test of drug-design methodologies

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Peptide drug modifications to enhance bioavailability and blood-brain barrier permeability.

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Protein drug oral delivery: the recent progress

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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Drug-like properties and the causes of poor solubility and poor permeability

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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Lead- and drug-like compounds: the rule-of-five revolution

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Molecular properties that influence the oral bioavailability of drug candidates

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The influence of drug-like concepts on decision-making in medicinal chemistry

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Conformational selection of inhibitors and substrates by proteolytic enzymes: implications for drug design and polypeptide processing

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Proteases universally recognize beta strands in their active sites

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Update 1 of: Proteases universally recognize beta strands in their active sites

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201401058

Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1.

21 January 2018

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Beta strand peptidomimetics as potent PDZ domain ligands

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Strategies for targeting protein-protein interactions with synthetic agents.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201401058

Protease inhibitors: current status and future prospects

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201401058

Protease inhibitors in the clinic.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201401058

Conformationally constrained macrocycles that mimic tripeptide beta-strands in water and aprotic solvents

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201401058

Regioselective structural and functional mimicry of peptides. Design of hydrolytically-stable cyclic peptidomimetic inhibitors of HIV-1 protease

21 January 2018

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Substrate-Based Cyclic Peptidomimetics of Phe-Ile-Val That Inhibit HIV-1 Protease Using a Novel Enzyme-Binding Mode

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Countering cooperative effects in protease inhibitors using constrained beta-strand-mimicking templates in focused combinatorial libraries

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Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease

21 January 2018

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A Novel Bicyclic Enzyme Inhibitor as a Consensus Peptidomimetic for the Receptor-Bound Conformations of 12 Peptidic Inhibitors of HIV-1 Protease

21 January 2018

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Crystal structures of highly constrained substrate and hydrolysis products bound to HIV-1 protease. Implications for the catalytic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Macrocycles mimic the extended peptide conformation recognized by aspartic, serine, cysteine and metallo proteases.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201401058

Conformationally constrained renin inhibitory peptides: cyclic (3-1)-1-(carboxymethyl)-L-prolyl-L-phenylalanyl-L-histidinamide as a conformational restriction at the P2-P4 tripeptide portion of the angiotensinogen template

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201401058

Design and synthesis of potent macrocyclic renin inhibitors

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201401058

Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase).

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201401058

Macrocyclic peptidomimetic inhibitors of beta-secretase (BACE): first X-ray structure of a macrocyclic peptidomimetic-BACE complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Macrocyclic inhibitors of beta-secretase: functional activity in an animal model.

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201401058

Structure-based design and synthesis of macrocyclic peptidomimetic beta-secretase (BACE-1) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Hydroxyethylamine-based inhibitors of BACE1: P₁-P₃ macrocyclization can improve potency, selectivity, and cell activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Macrocyclic inhibitors of the malarial aspartic proteases plasmepsin I, II, and IV.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Synthesis and biological activity of new conformationally restricted analogues of pepstatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Peptidomimetic therapeutic agents targeting the protease enzyme of the human immunodeficiency virus and hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

In vitro activity and preclinical profile of TMC435350, a potent hepatitis C virus protease inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Macrocyclic inhibitors for the serine protease plasmin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Comparison of the structures of the cyclotheonamide A complexes of human alpha-thrombin and bovine beta-trypsin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Molecular modeling, synthesis, and biological evaluation of macrocyclic calpain inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Peptides and peptidomimetics in medicine, surgery and biotechnology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Clinically validated peptides as templates for de novo peptidomimetic drug design at G-protein-coupled receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Contemporary strategies for peptide macrocyclization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Native chemical ligation applied to the synthesis and bioengineering of circular peptides and proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

The cyclization of peptides and depsipeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

N-methylated cyclic pentaalanine peptides as template structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Conformational preference and potential templates of N-methylated cyclic pentaalanine peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

The backbone N-(4-azidobutyl) linker for the preparation of peptide chimera.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Synthesis of a biologically active triazole-containing analogue of cystatin A through successive peptidomimetic alkyne-azide ligations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Pseudoprolines as removable turn inducers: tools for the cyclization of small peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Update 1 of: Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Small molecular probes for G-protein-coupled C5a receptors: conformationally constrained antagonists derived from the C terminus of the human plasma protein C5a.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Potent cyclic antagonists of the complement C5a receptor on human polymorphonuclear leukocytes. Relationships between structures and activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Function, structure and therapeutic potential of complement C5a receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Multiconformational NMR analysis of sandostatin (octreotide): equilibrium between beta-sheet and partially helical structures

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https://api.crossref.org/works/10.1002%2FANIE.201401058

Structure of octreotide, a somatostatin analogue

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https://api.crossref.org/works/10.1002%2FANIE.201401058

Novel octreotide dicarba-analogues with high affinity and different selectivity for somatostatin receptors

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https://api.crossref.org/works/10.1002%2FANIE.201401058

Template-constrained somatostatin analogues: a biphenyl linker induces a type-V' turn

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201401058

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Identification of putative agouti-related protein(87-132)-melanocortin-4 receptor interactions by homology molecular modeling and validation using chimeric peptide ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Growth hormone secretagogues: characterization, efficacy, and minimal bioactive conformation

21 January 2018

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https://api.crossref.org/works/10.1002%2FANIE.201401058

Structure-activity studies of the melanocortin peptides: discovery of potent and selective affinity antagonists for the hMC3 and hMC4 receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-DPhe-Arg-Trp-Lys]-NH(2).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Integrins as therapeutic targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Cilengitide: the first anti-angiogenic small molecule drug candidate design, synthesis and clinical evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Ligands for mapping alphavbeta3-integrin expression in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Beta-turn modified gramicidin S analogues containing arylated sugar amino acids display antimicrobial and hemolytic activity comparable to the natural product

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Sequence inversion and phenylalanine surrogates at the beta-turn enhance the antibiotic activity of gramicidin S.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Beta-turn Phe in HIV-1 Env binding site of CD4 and CD4 mimetic miniprotein enhances Env binding affinity but is not required for activation of co-receptor/17b site

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Synthesis and evaluation of pseudopeptide analogues of a specific CXCR4 inhibitor, T140: the insertion of an (E)-alkene dipeptide isostere into the betaII'-turn moiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Protein α-turns recreated in structurally stable small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

New selective AT2 receptor ligands encompassing a gamma-turn mimetic replacing the amino acid residues 4-5 of angiotensin II act as agonists.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Beta-hairpin peptidomimetics: design, structures and biological activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Conformationally constrained peptides from CD2 to modulate protein-protein interactions between CD2 and CD58.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Properties and structure-activity studies of cyclic beta-hairpin peptidomimetics based on the cationic antimicrobial peptide protegrin I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Positional effects of click cyclization on β-hairpin structure, stability, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Systematic analysis of helical protein interfaces reveals targets for synthetic inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Stabilized helical peptides: overview of the technologies and therapeutic promises.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Inhibition of α-helix-mediated protein-protein interactions using designed molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

New modalities in conformationally constrained peptides for potency, selectivity and cell permeation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Lactam bridge stabilization of alpha-helical peptides: ring size, orientation and positional effects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Probing the functional conformation of neuropeptide Y through the design and study of cyclic analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Synthesis and opioid activity of conformationally constrained dynorphin A analogues. 1. Conformational constraint in the "message" sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Design, synthesis, and biological activities of cyclic lactam peptide analogues of dynorphine A(1-11)-NH2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Cyclic parathyroid hormone-related protein antagonists: lysine 13 to aspartic acid 17 [i to (i + 4)] side chain to side chain lactamization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Synthesis and relative potencies of new constrained CRF antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

The glycine residue in cyclic lactam analogues of galanin(1-16)-NH2 is important for stabilizing an N-terminal helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

The effect of C-terminal helix stabilization on specific DNA binding by monomeric GCN4 peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Lactam constraints provide insights into the receptor-bound conformation of secretin and stabilize a receptor antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

An inhibitor of the interaction of thyroid hormone receptor beta and glucocorticoid interacting protein 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Novel selective inhibitors of the interaction of individual nuclear hormone receptors with a mutually shared steroid receptor coactivator 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Steroid receptor coactivator peptidomimetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Ligand-selective inhibition of the interaction of steroid receptor coactivators and estrogen receptor isoforms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Single turn peptide alpha helices with exceptional stability in water

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Modular alpha-helical mimetics with antiviral activity against respiratory syncitial virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Targeting quorum sensing and competence stimulation for antimicrobial chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Novel helix-constrained nociceptin derivatives are potent agonists and antagonists of ERK phosphorylation and thermal analgesia in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Truncated and helix-constrained peptides with high affinity and specificity for the cFos coiled-coil of AP-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Lactam-stabilized helical analogues of the analgesic μ-conotoxin KIIIA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Side chain cyclization based on serine residues: synthesis, structure, and activity of a novel cyclic analogue of the parathyroid hormone fragment 1-11.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Ring-closing metathesis of olefinic peptides: design, synthesis, and structural characterization of macrocyclic helical peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Stereochemical effects of all-hydrocarbon tethers in i,i+4 stapled peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Monosubstituted alkenyl amino acids for peptide "stapling".

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

A stapled BID BH3 helix directly binds and activates BAX

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Direct inhibition of the NOTCH transcription factor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

A stapled p53 helix overcomes HDMX-mediated suppression of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Stapled peptides with improved potency and specificity that activate p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Inhibition of nutlin-resistant HDM2 mutants by stapled peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Design and structure of stapled peptides binding to estrogen receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Antiviral activity of α-helical stapled peptides designed from the HIV-1 capsid dimerization domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Membrane permeability of hydrocarbon-cross-linked peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Helix stabilization of amphipathic peptides by hydrocarbon stapling increases cholesterol efflux by the ABCA1 transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Synthesis and conformational analysis of a cyclic peptide obtained via i to i+4 intramolecular side-chain to side-chain azide-alkyne 1,3-dipolar cycloaddition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Design of triazole-stapled BCL9 α-helical peptides to target the β-catenin/B-cell CLL/lymphoma 9 (BCL9) protein-protein interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Thioether side chain cyclization for helical peptide formation: inhibitors of estrogen receptor-coactivator interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Potent inhibitors of LXXLL-based protein-protein interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Achieving cell penetration with distance-matching cysteine cross-linkers: a facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Development of α-helical calpain probes by mimicking a natural protein-protein interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

A perfluoroaryl-cysteine S(N)Ar chemistry approach to unprotected peptide stapling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Facile synthesis of stapled, structurally reinforced peptide helices via a photoinduced intramolecular 1,3-dipolar cycloaddition reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Synthesis of cell-permeable stapled peptide dual inhibitors of the p53-Mdm2/Mdmx interactions via photoinduced cycloaddition

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Photocontrollable peptide-based switches target the anti-apoptotic protein Bcl-xL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

NMR solution structure of a photoswitchable apoptosis activating Bak peptide bound to Bcl-xL

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Comparative α-helicity of cyclic pentapeptides in water

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Nucleation and stability of hydrogen-bond surrogate-based alpha-helices

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Contemporary strategies for the stabilization of peptides in the alpha-helical conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

A hydrogen bond surrogate approach for stabilization of short peptide sequences in alpha-helical conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Solid-phase synthesis of short α-helices stabilized by the hydrogen bond surrogate approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

End-Capped α-Helices as Modulators of Protein Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

A highly stable short alpha-helix constrained by a main-chain hydrogen-bond surrogate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Solid phase synthesis of hydrogen bond surrogate derived alpha-helices: resolving the case of a difficult amide coupling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Reversible α-helix formation controlled by a hydrogen bond surrogate

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Design, synthesis and protein-targeting properties of thioether-linked hydrogen bond surrogate helices

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

High specificity in protein recognition by hydrogen-bond-surrogate α-helices: selective inhibition of the p53/MDM2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Enhanced metabolic stability and protein-binding properties of artificial alpha helices derived from a hydrogen-bond surrogate: application to Bcl-xL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Inhibition of hypoxia inducible factor 1-transcription coactivator interaction by a hydrogen bond surrogate alpha-helix

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

An orthosteric inhibitor of the Ras-Sos interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Using a beta-hairpin to mimic an alpha-helix: cyclic peptidomimetic inhibitors of the p53-HDM2 protein-protein interaction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Design of beta-hairpin peptidomimetics that inhibit binding of alpha-helical HIV-1 Rev protein to the rev response element RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Essential structural requirements for specific recognition of HIV TAR RNA by peptide mimetics of Tat protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Peptidomimetic inhibitors targeting the CCR5-binding site on the human immunodeficiency virus type-1 gp120 glycoprotein complexed to CD4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Chemistry. Seamless proteins tie up their loose ends

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Form and function in cyclic peptide natural products: a pharmacokinetic perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Various mechanisms in cyclopeptide production from precursors synthesized independently of non-ribosomal peptide synthetases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Cyclosporin A, a Peptide Metabolite from Trichoderma polysporum (Link ex Pers.) Rifai, with a remarkable immunosuppressive activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

The discovery, isolation, elucidation of structure, and synthesis of antamanide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Structure elucidation at the nanomole scale. 1. Trisoxazole macrolides and thiazole-containing cyclic peptides from the nudibranch Hexabranchus sanguineus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Total Synthesis, Structure, and Oral Absorption of a Thiazole Cyclic Peptide, Sanguinamide A

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Azole-based cyclic peptides from the sea squirt Lissoclinum patella: old scaffolds, new avenues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Thiazole and oxazole alkaloids: isolation and synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

From amino acids to heteroaromatics--thiopeptide antibiotics, nature's heterocyclic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Antibiotic GE2270 a: a novel inhibitor of bacterial protein synthesis. I. Isolation and characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Total synthesis of thiopeptide antibiotics GE2270A, GE2270T, and GE2270C1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Structure and activity of largazole, a potent antiproliferative agent from the Floridian marine cyanobacterium Symploca sp.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Largazole: from discovery to broad-spectrum therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Structure--activity relationships of polymyxin antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

On the chemistry, toxicology and genetics of the cyanobacterial toxins, microcystin, nodularin, saxitoxin and cylindrospermopsin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Tumor promoters--microcystin-LR, nodularin and TNF-α and human cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Exploration of the conformational space of oxytocin and arginine-vasopressin using the electrostatically driven Monte Carlo and molecular dynamics methods.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Crystal structure of the neurophysin-oxytocin complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Designing peptide receptor agonists and antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

FR901228, a potent antitumor antibiotic, is a novel histone deacetylase inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Multifaceted roles of disulfide bonds. Peptides as therapeutics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Spider-venom peptides that target voltage-gated sodium channels: pharmacological tools and potential therapeutic leads.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Spider venoms: a rich source of acylpolyamines and peptides as new leads for CNS drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Overview of scorpion toxins specific for Na+ channels and related peptides: biodiversity, structure-function relationships and evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Structure and function of snake venom cysteine-rich secretory proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

The toxicogenomic multiverse: convergent recruitment of proteins into animal venoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Complex cocktails: the evolutionary novelty of venoms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

High-resolution structure of a potent, cyclic proteinase inhibitor from sunflower seeds

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Conus venoms: a rich source of novel ion channel-targeted peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Diversity of the neurotoxic Conus peptides: a model for concerted pharmacological discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Alpha-conotoxins as pharmacological probes of nicotinic acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Conotoxins: natural product drug leads

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

The synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

The yin and yang of human Beta-defensins in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

21 January 2018

Human beta-defensin-2

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

The NMR structure of human beta-defensin-2 reveals a novel alpha-helical segment

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

The cystine knot motif in toxins and implications for drug design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Decoding the membrane activity of the cyclotide kalata B1: the importance of phosphatidylethanolamine phospholipids and lipid organization on hemolytic and anti-HIV activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

The pharmacokinetics, pharmacodynamics, clinical efficacy, safety and tolerability of linaclotide

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Pharmacology and clinical potential of guanylyl cyclase C agonists in the treatment of ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Aflibercept: a novel VEGF targeted agent to explore the future perspectives of anti-angiogenic therapy for the treatment of multiple tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Structural basis of transcription: alpha-amanitin-RNA polymerase II cocrystal at 2.8 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Treatment of amatoxin poisoning: 20-year retrospective analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Über die Giftstoffe des Knollenblätterpilzes. IV

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Modification of actins by phallotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Bouvardin and deoxybouvardin, antitumor cyclic hexapeptides from Bouvardia ternifolia (Rubiaceae)

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Structural studies on the peptide moroidin from laportea moroides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Phage-encoded combinatorial chemical libraries based on bicyclic peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Bicyclic peptide inhibitor reveals large contact interface with a protease target

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Structurally diverse cyclisation linkers impose different backbone conformations in bicyclic peptides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Polycyclic peptide therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Screening bicyclic peptide libraries for protein-protein interaction inhibitors: discovery of a tumor necrosis factor-α antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Peptide bicycles that inhibit the Grb2 SH2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Bicyclic peptide inhibitor of urokinase-type plasminogen activator: mode of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Biosynthesis and mode of action of lantibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Vancomycin, teicoplanin, and ramoplanin: synthetic and mechanistic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Different modes of vancomycin and D-alanyl-D-alanine peptidase binding to cell wall peptide and a possible role for the vancomycin resistance protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

CuI-Catalyzed Azideâ Alkyne Intramoleculari-to-(i+4) Side-Chain-to-Side-Chain Cyclization Promotes the Formation of Helix-Like Secondary Structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

Disulfide and amide-bridged cyclic peptide analogues of the VEGF81–91 fragment: Synthesis, conformational analysis and biological evaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

A potent cyclic hexapeptide analogue of somatostatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201401058

FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.47.301

Identifiers

DOI

10.1002/ANIE.201401058

1 reference

21 June 2017

1 reference

PubMed ID

25287434