Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus. (Q30152739)

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English	Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.	scientific article

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21 March 2020

Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus (English)

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21 March 2020

crystal structure

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Streptomyces globisporus

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Streptomyces globisporus

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inferred from title

Chin-Yuan Chang

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21 March 2020

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21 March 2020

Jeffrey D. Rudolf

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Ragothaman Yennamalli

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Andrzej Joachimiak

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George N Phillips

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Craig A Bingman

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Kemin Tan

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Ming Ma

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Weijun Xu

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21 March 2020

Lance Bigelow

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Gyorgy Babnigg

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Xiaohui Yan

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Ben Shen

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1 September 2016

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21 March 2020

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21 March 2020

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21 March 2020

5142-5154

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21 March 2020

36

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21 March 2020

Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery

1 reference

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The radiomimetic enediyne, 20'-deschloro-C-1027 induces inter-strand DNA crosslinks in hypoxic cells and overcomes cytotoxic radioresistance

1 reference

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Identification of promiscuous ene-reductase activity by mining structural databases using active site constellations

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3 June 2018

Flavin dependent monooxygenases

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1 reference

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1 reference

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1 reference

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1 reference

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Characterization of Chlorophenol 4-Monooxygenase (TftD) and NADH:FAD Oxidoreductase (TftC) of Burkholderia cepacia AC1100

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Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027.

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3 June 2018

Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis

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3 June 2018

Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027

1 reference

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12 December 2020

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Biosynthesis of the enediyne antitumor antibiotic C-1027

1 reference

https://pubmed.ncbi.nlm.nih.gov/27560143

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1021/ACS.BIOCHEM.6B00713

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