Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027. (Q42163866)

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scientific article published on 22 April 2008

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English	Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027.	scientific article published on 22 April 2008

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scholarly article

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6 January 2020

Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027 (English)

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6 January 2020

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Shuangjun Lin

1

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6 January 2020

Steven G Van Lanen

2

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6 January 2020

Ben Shen

3

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22 April 2008

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6 January 2020

Journal of the American Chemical Society

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130

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6 January 2020

6616-6623

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6 January 2020

Functional analysis of the small component of the 4-hydroxyphenylacetate 3-monooxygenase of Escherichia coli W: a prototype of a new Flavin:NAD(P)H reductase subfamily

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027 apoprotein

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of 4-hydroxyphenylacetate 3-hydroxylase (HpaB) of Escherichia coli as a reduced flavin adenine dinucleotide-utilizing monooxygenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coumarin formation in novobiocin biosynthesis: beta-hydroxylation of the aminoacyl enzyme tyrosyl-S-NovH by a cytochrome P450 NovI

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Solution structures of C-1027 apoprotein and its complex with the aromatized chromophore

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aminoacyl-S-enzyme intermediates in beta-hydroxylations and alpha,beta-desaturations of amino acids in peptide antibiotics

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein and ligand dynamics in 4-hydroxybenzoate hydroxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of beta-hydroxy histidine in the biosynthesis of nikkomycin antibiotics

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of the enediyne antitumor antibiotic C-1027

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An overview of the mechanism, substrate specificities, and structure of FMOs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel 4-methylideneimidazole-5-one-containing tyrosine aminomutase in enediyne antitumor antibiotic C-1027 biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coordinated production and utilization of FADH2 by NAD(P)H-flavin oxidoreductase and 4-hydroxyphenylacetate 3-monooxygenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and primary structure of C-1027-AG, a selective antagonist of antitumor antibiotic C-1027, from Streptomyces globisporus

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enediyne Natural Products: Biosynthesis and Prospect Towards Engineering Novel Antitumor Agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic Analysis of the 4-Methylideneimidazole-5-one-Containing Tyrosine Aminomutase in Enediyne Antitumor Antibiotic C-1027 Biosynthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis of the beta-amino acid moiety of the enediyne antitumor antibiotic C-1027 featuring beta-amino acyl-S-carrier protein intermediates

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamics involved in catalysis by single-component and two-component flavin-dependent aromatic hydroxylases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flavoprotein monooxygenases, a diverse class of oxidative biocatalysts

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substrate specificity of the adenylation enzyme SgcC1 involved in the biosynthesis of the enediyne antitumor antibiotic C-1027

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic hydroxylation of aromatic compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single chemical modifications of the C-1027 enediyne core, a radiomimetic antitumor drug, affect both drug potency and the role of ataxia-telangiectasia mutated in cellular responses to DNA double-strand breaks

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure of L-tyrosine 2,3-aminomutase from the C-1027 enediyne antitumor antibiotic biosynthetic pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Designer enediynes generate DNA breaks, interstrand cross-links, or both, with concomitant changes in the regulation of DNA damage responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of action of a new macromolecular antitumor antibiotic, C-1027.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Catabolism of aromatic biogenic amines by Pseudomonas aeruginosa PAO1 via meta cleavage of homoprotocatechuic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new macromolecular antitumor antibiotic, C-1027. I. Discovery, taxonomy of producing organism, fermentation and biological activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new macromolecular antitumor antibiotic, C-1027. II. Isolation and physico-chemical properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate,2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate. Evidence for a proton [...]

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A single binding mode of activated enediyne C1027 generates two types of double-strand DNA lesions: deuterium isotope-induced shuttling between adjacent nucleotide target sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mobile flavin of 4-OH benzoate hydroxylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular characterization of 4-hydroxyphenylacetate 3-hydroxylase of Escherichia coli. A two-protein component enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Some characteristics of DNA strand scission by macromolecular antitumor antibiotic C-1027 containing a novel enediyne chromophore

1 reference

https://pubmed.ncbi.nlm.nih.gov/18426211

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JA710601D

1 reference

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6 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18426211%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18426211%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

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