Opportunities and Challenges in Antiparasitic Drug Discovery (Q29999214)

Europe PubMed Central

title

Opportunities and Challenges in Antiparasitic Drug Discovery (English)

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20 May 2017

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Richard Pink

1

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20 May 2017

Alan Hudson

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2

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20 May 2017

Marie-Annick Mouriès

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3

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20 May 2017

Mary Bendig

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4

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20 May 2017

publication date

September 2005

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Nature Reviews Drug Discovery

20 May 2017

published in

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20 May 2017

volume

4

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20 May 2017

issue

9

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20 May 2017

page(s)

727-740

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Drug development for neglected diseases: a deficient market and a public-health policy failure

20 May 2017

cites work

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Traditional herbal medicines for malaria

22 May 2017

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Insights into antifolate resistance from malarial DHFR-TS structures

22 May 2017

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In vivo antimalarial activity of the beta-carboline alkaloid manzamine A

22 May 2017

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22 May 2017

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Hit and lead generation: beyond high-throughput screening

22 May 2017

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Identification of an antimalarial synthetic trioxolane drug development candidate

22 May 2017

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Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum

22 May 2017

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Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

22 May 2017

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Structure of 2C-methyl-D-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development

22 May 2017

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Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani

22 May 2017

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Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design

22 May 2017

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Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum

22 May 2017

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Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum

22 May 2017

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Identification and recombinant expression of glyceraldehyde-3-phosphate dehydrogenase of Plasmodium falciparum

22 May 2017

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Molecular characterization of bifunctional hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase from Plasmodium falciparum

22 May 2017

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Virtual drug discovery and development for neglected diseases through public-private partnerships

22 May 2017

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Engaging biotechnology companies in the development of innovative solutions for diseases of poverty

31 March 2020

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Research on infectious diseases requires better coordination

31 March 2020

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Antimalarial drug discovery: old and new approaches

31 March 2020

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Tuberculosis – strategies towards anti-infectives for a chronic disease

31 March 2020

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Trading on traditional medicines

31 March 2020

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Combination of eflornithine and melarsoprol for melarsoprol-resistant Gambian trypanosomiasis

31 March 2020

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Antimalarial combinations

31 March 2020

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Specific chemotherapy of Chagas disease: controversies and advances

31 March 2020

1 reference

31 March 2020

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Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity.

31 March 2020

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The antiparasitic moxidectin: safety, tolerability, and pharmacokinetics in humans

31 March 2020

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Medicines for Malaria Venture new developments in antimalarials

31 March 2020

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Antiparasitic properties of medicinal plants and other naturally occurring products

31 March 2020

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Qinghaosu (artemisinin): an antimalarial drug from China

31 March 2020

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Structure-activity relationships of antileishmanial and antimalarial chalcones

31 March 2020

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In vitro and in vivo antimalarial activities of a non-glycosidic 18-membered macrolide antibiotic, borrelidin, against drug-resistant strains of Plasmodia

31 March 2020

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In vitro and in vivo activities of a triterpenoid saponin extract (PX-6518) from the plant Maesa balansae against visceral leishmania species

31 March 2020

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Computational analysis of Plasmodium falciparum metabolism: organizing genomic information to facilitate drug discovery

31 March 2020

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Taking inventory: antibacterial agents currently at or beyond phase 1.

31 March 2020

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Antibiotics: where did we go wrong?

31 March 2020

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Antibacterial research and development in the 21(st) Century--an industry perspective of the challenges

31 March 2020

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High-throughput drug discovery: what can we expect from HTS?

31 March 2020

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Chemistry-to-gene screens in Caenorhabditis elegans

31 March 2020

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RNAi-based discovery and validation of new drug targets in filarial nematodes

31 March 2020

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Cysteine proteases of parasitic organisms

31 March 2020

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Application of combinatorial and parallel synthesis chemistry methodologies to antiparasitic drug discovery

31 March 2020

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Antimalarial drug discovery: efficacy models for compound screening

31 March 2020

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Antimalarial activities of novel synthetic cysteine protease inhibitors

31 March 2020

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The chemotherapy of rodent malaria. LX. The importance of formulation in evaluating the blood schizontocidal activity of some endoperoxide antimalarials

31 March 2020

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Public – private 'partnerships' in health – a global call to action

31 March 2020

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31 March 2020

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Conquering the intolerable burden of malaria: what's new, what's needed: a summary.

31 March 2020

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Fosmidomycin, a novel chemotherapeutic agent for malaria

31 March 2020

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Miltefosine, an oral agent, for the treatment of Indian visceral leishmaniasis

31 March 2020

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Site of action of the antimalarial hydroxynaphthoquinone, 2-[trans-4-(4'-chlorophenyl) cyclohexyl]-3- hydroxy-1,4-naphthoquinone (566C80)

31 March 2020

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Fosmidomycin-clindamycin for Plasmodium falciparum Infections in African children

31 March 2020

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Current situation of African trypanosomiasis

31 March 2020

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A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents.

31 March 2020

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Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy

31 March 2020

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Modes of action of anthelmintic drugs

31 March 2020

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Mode of action of benzimidazoles.

31 March 2020

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The life and times of ivermectin - a success story

31 March 2020

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Molecular biology and electrophysiology of glutamate-gated chloride channels of invertebrates

31 March 2020

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High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

31 March 2020

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Cysteine proteases of malaria parasites

31 March 2020

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Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.

31 March 2020

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Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.

31 March 2020

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Specialized fatty acid synthesis in African trypanosomes: myristate for GPI anchors

31 March 2020

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Peptide deformylase of eukaryotic protists: a target for new antiparasitic agents?

31 March 2020

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The hexose transporter of Plasmodium falciparum is a worthy drug target.

31 March 2020

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Expression, localization and alternative function of cytoplasmic asparaginyl-tRNA synthetase in Brugia malayi

31 March 2020

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Identification and activity of a series of azole-based compounds with lactate dehydrogenase-directed anti-malarial activity.

31 March 2020

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An alpha-proteobacterial type malate dehydrogenase may complement LDH function in Plasmodium falciparum. Cloning and biochemical characterization of the enzyme

31 March 2020

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Proteases involved in erythrocyte invasion by the malaria parasite: function and potential as chemotherapeutic targets

31 March 2020

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Cyclin-dependent kinase homologues of Plasmodium falciparum

31 March 2020

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Rational inhibitor design and iterative screening in the identification of selective plasmodial cyclin dependent kinase inhibitors.

31 March 2020

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In vitro assays for evaluation of drug activity against Leishmania spp.

31 March 2020

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Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.

31 March 2020

1 reference

The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro

31 March 2020

1 reference

O-alkoxyamidine prodrugs of furamidine: in vitro transport and microsomal metabolism as indicators of in vivo efficacy in a mouse model of Trypanosoma brucei rhodesiense infection

31 March 2020

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A method to assess invasion and intracellular replication of Trypanosoma cruzi based on differential uracil incorporation.

31 March 2020

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Parasitological cure of acute and chronic experimental Chagas disease using the long-acting experimental triazole TAK-187. Activity against drug-resistant Trypanosoma cruzi strains

31 March 2020

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In vitro responses of praziquantel-resistant and -susceptible Schistosoma mansoni to praziquantel

31 March 2020

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Determination of ED50 values for praziquantel in praziquantel-resistant and -susceptible Schistosoma mansoni isolates

31 March 2020

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Comparative study of the effects of artemether and artesunate on juvenile and adult Schistosoma mansoni in experimentally infected mice

31 March 2020

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An overview of animal models in experimental schistosomiasis and refinements in the use of non-human primates

31 March 2020

1 reference

Dipetalonema viteae and Brugia pahangi transplant infections in gerbils for use in antifilarial screening

31 March 2020

1 reference

Chemotherapy of Onchocerca lienalis microfilariae in mice: a model for the evaluation of novel compounds for the treatment of onchocerciasis.

31 March 2020

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Eflornithine for the treatment of human African trypanosomiasis

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Experimental models of Schistosoma mansoni infection

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1824

2 references

20 May 2017

Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

3399433

1049738468

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3399433

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference