Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics. (Q35077278)

From Wikidata

Jump to navigation Jump to search

scientific article

Language	Label	Description	Also known as
English	Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615314%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

1 reference

Europe PubMed Central

Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615314%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

0 references

Elisabeth P Carpenter

6

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615314%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Michael H. Gelb

1

object named as

Michael H Gelb

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615314%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Frederick S Buckner

3

object named as

Frederick S Buckner

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615314%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

4

object named as

Kohei Yokoyama

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615314%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Richard T Eastman

5

object named as

Richard Eastman

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615314%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Wesley C Van Voorhis

2

object named as

Wesley C Van Voorhis

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615314%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

author name string

Chrysoula Panethymitaki

7

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615314%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Katherine A Brown

8

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615314%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Deborah F Smith

9

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615314%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

publication date

1 February 2003

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615314%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Molecular and Biochemical Parasitology

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615314%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

126

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615314%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

155-163

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615314%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

2

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615314%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Prenyl proteins in eukaryotic cells: a new type of membrane anchor

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein prenyltransferases.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Brain G protein gamma subunits contain an all-trans-geranylgeranylcysteine methyl ester at their carboxyl termini

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Binding of the delta subunit to rod phosphodiesterase catalytic subunits requires methylated, prenylated C-termini of the catalytic subunits

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The delta subunit of type 6 phosphodiesterase reduces light-induced cGMP hydrolysis in rod outer segments

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Prenylation of proteins in Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterisation of protein isoprenylation in procyclic form Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The effects of protein farnesyltransferase inhibitors on trypanosomatids: inhibition of protein farnesylation and cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Protein prenyl transferase activities of Plasmodium falciparum.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Farnesyltransferase inhibitors: a new class of cancer chemotherapeutics

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Current status of clinical trials of farnesyltransferase inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Cloning, heterologous expression, and distinct substrate specificity of protein farnesyltransferase from Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

GTPases in protozoan parasites: tools for cell biology and chemotherapy.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

TcRho1, a farnesylated Rho family homologue from Trypanosoma cruzi: cloning, trans-splicing, and prenylation studies

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Geranylgeranylated proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic and biochemical studies of protein N-myristoylation

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The biology and enzymology of protein N-myristoylation

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Electrostatic interaction of myristoylated proteins with membranes: simple physics, complicated biology

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The structure of myristoyl-CoA:protein N-myristoyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of the anti-fungal target N-myristoyl transferase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Drosophila embryos lacking N-myristoyltransferase have multiple developmental defects.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Disruption of the yeast N-myristoyl transferase gene causes recessive lethality.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic studies reveal that myristoylCoA:protein N-myristoyltransferase is an essential enzyme in Candida albicans

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular cloning, genomic organization, and biochemical characterization of myristoyl-CoA:protein N-myristoyltransferase from Arabidopsis thaliana

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

A second mammalian N-myristoyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifung

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Myristic acid analogs are inhibitors of Junin virus replication

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic and biochemical studies establish that the fungicidal effect of a fully depeptidized inhibitor of Cryptococcus neoformans myristoyl-CoA:protein N-myristoyltransferase (Nmt) is Nmt-dependent.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Fatty acid synthesis in African trypanosomes: a solution to the myristate mystery.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

An analog of myristic acid with selective toxicity for African trypanosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Toxicity of myristic acid analogs toward African trypanosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of a hydrophilic surface protein in infective stages of Leishmania major

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterisation of a second protein encoded by the differentially regulated LmcDNA16 gene family of Leishmania major.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunization with a recombinant stage-regulated surface protein from Leishmania donovani induces protection against visceral leishmaniasis

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Acylation-dependent Protein Export in Leishmania

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Flagellar protein localization mediated by a calcium-myristoyl/palmitoyl switch mechanism

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

A novel phosphatidylinositol-phospholipase C of Trypanosoma cruzi that is lipid modified and activated during trypomastigote to amastigote differentiation.

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

CAP5.5, a life-cycle-regulated, cytoskeleton-associated protein is a member of a novel family of calpain-related proteins in Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of N-myristoyltransferase from Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Comparative protein modelling by satisfaction of spatial restraints

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Human N-myristoyltransferase amino-terminal domain involved in targeting the enzyme to the ribosomal subcellular fraction

1 reference

https://api.crossref.org/works/10.1016%2FS0166-6851%2802%2900282-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0166-6851(02)00282-7

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615314%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12615314%20AND%20SRC:MED&resulttype=core&format=json

1 November 2019

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q35077278&oldid=1742897608"