The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing (Q39481136)

12 September 2017

title

The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing (English)

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ribonucleoprotein complex

12 September 2017

main subject

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Maniatis T

1

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12 September 2017

Reed R

series ordinal

2

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12 September 2017

publication date

1 February 1987

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12 September 2017

language of work or name

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12 September 2017

volume

325

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12 September 2017

issue

6106

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12 September 2017

page(s)

673-678

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publication type of scholarly work

12 September 2017

review article

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Biological catalysis by RNA.

cites work

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7 January 2021

Are snRNPs involved in splicing?

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7 January 2021

A mechanism for RNA splicing

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7 January 2021

Sequence of U1 RNA from Drosophila melanogaster: implications for U1 secondary structure and possible involvement in splicing

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7 January 2021

Splicing of adenovirus RNA in a cell-free transcription system

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7 January 2021

Splicing of in vitro synthesized messenger RNA precursors in HeLa cell extracts

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7 January 2021

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

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7 January 2021

Human beta-globin pre-mRNA synthesized in vitro is accurately spliced in Xenopus oocyte nuclei

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7 January 2021

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

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7 January 2021

Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus

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7 January 2021

Isolation and characterization of rabbit anti-m3 2,2,7G antibodies

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7 January 2021

The 3' splice site of pre-messenger RNA is recognized by a small nuclear ribonucleoprotein

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7 January 2021

Evidence for the existence of snRNAs U4 and U6 in a single ribonucleoprotein complex and for their association by intermolecular base pairing

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7 January 2021

U4 and U6 RNAs coexist in a single small nuclear ribonucleoprotein particle

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7 January 2021

Biochemical complementation with RNA in the Xenopus oocyte: A small rna is required for the generation of 3′ histone mRNA termini

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7 January 2021

A small nuclear ribonucleoprotein is required for splicing of adenoviral early RNA sequences

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7 January 2021

Splicing of messenger RNA precursors is inhibited by antisera to small nuclear ribonucleoprotein

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7 January 2021

The 5′ terminus of the RNA moiety of U1 small nuclear ribonucleoprotein particles is required for the splicing of messenger RNA precursors

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7 January 2021

Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro

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7 January 2021

U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing

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7 January 2021

U1, U2, and U4/U6 small nuclear ribonucleoproteins are required for in vitro splicing but not polyadenylation

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7 January 2021

Pre-mRNA splicing in vitro requires intact U4/U6 small nuclear ribonucleoprotein

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7 January 2021

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

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7 January 2021

Lariat RNA's as Intermediates and Products in the Splicing of Messenger RNA precursors

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7 January 2021

Splicing of messenger RNA precursors

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7 January 2021

In vivo splicing products of the rabbit β-globin pre-mRNA

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7 January 2021

Intron splicing: a conserved internal signal in introns of animal pre-mRNAs

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7 January 2021

Intron sequences involved in lariat formation during pre-mRNA splicing

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7 January 2021

A role for branchpoints in splicing in vivo

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7 January 2021

Cryptic branch point activation allows accurate in vitro splicing of human beta-globin intron mutants

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7 January 2021

Specific and stable intron-factor interactions are established early during in vitro pre-mRNA splicing

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7 January 2021

The U1 small nuclear RNA-protein complex selectively binds a 5' splice site in vitro

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7 January 2021

U1 RNA-protein complex preferentially binds to both 5' and 3' splice junction sequences in RNA or single-stranded DNA

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7 January 2021

Novel models for RNA splicing that involve a small nuclear RNA

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7 January 2021

Intron splicing: a conserved internal signal in introns of Drosophila pre-mRNAs

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7 January 2021

Base-pairing interactions between small nuclear RNAs and nuclear RNA precursors as revealed by psoralen cross-linking in vivo

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7 January 2021

Small Nuclear RNA U2 Is Base-Paired to Heterogeneous Nuclear RNA

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7 January 2021

A compensatory base change in U1 snRNA suppresses a 5' splice site mutation

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7 January 2021

Three distinct activities possibly involved in mRNA splicing are found in a nuclear fraction lacking U1 and U2 RNA.

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7 January 2021

A protein that specifically recognizes the 3' splice site of mammalian pre-mRNA introns is associated with a small nuclear ribonucleoprotein

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7 January 2021

A protein associated with small nuclear ribonucleoprotein particles recognizes the 3' splice site of premessenger RNA

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7 January 2021

Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit β-globin gene

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7 January 2021

Specific transcription and RNA splicing defects in five cloned β-thalassaemia genes

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7 January 2021

A role for exon sequences and splice-site proximity in splice-site selection

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7 January 2021

Heterogeneous nuclear ribonucleoproteins: role in RNA splicing

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7 January 2021

Isolation and characterization of two fractions from HeLa cells required for mRNA splicing in vitro

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7 January 2021

RNA splicing products formed with isolated fractions from HeLa cells are associated with fast-sedimenting complexes

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7 January 2021

The "spliceosome": yeast pre-messenger RNA associates with a 40S complex in a splicing-dependent reaction

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7 January 2021

Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences

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7 January 2021

A multicomponent complex is involved in the splicing of messenger RNA precursors

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7 January 2021

Assembly in an in vitro splicing reaction of a mouse insulin messenger RNA precursor into a 60-40S ribonucleoprotein complex

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7 January 2021

Ribonucleoprotein complex formation during pre-mRNA splicing in vitro

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7 January 2021

Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs

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7 January 2021

Affinity chromatography of splicing complexes: U2, U5, and U4 + U6 small nuclear ribonucleoprotein particles in the spliceosome

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7 January 2021

Lariat structures are in vivo intermediates in yeast pre-mRNA splicing

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7 January 2021

In vivo characterization of yeast mRNA processing intermediates

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7 January 2021

Molecular consequences of specific intron mutations on yeast mRNA splicing in vivo and in vitro

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7 January 2021

Evidence for an intron-contained sequence required for the splicing of yeast RNA polymerase II transcripts

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7 January 2021

Evidence for the biochemical role of an internal sequence in yeast nuclear mRNA introns: implications for U1 RNA and metazoan mRNA splicing

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7 January 2021

Point mutations identify the conserved, intron-contained TACTAAC box as an essential splicing signal sequence in yeast

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7 January 2021

A point mutation in the conserved hexanucleotide at a yeast 5' splice junction uncouples recognition, cleavage, and ligation

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7 January 2021

Activation of a cryptic TACTAAC box in the Saccharomyces cerevisiae actin intron

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7 January 2021

Mutations in conserved intron sequences affect multiple steps in the yeast splicing pathway, particularly assembly of the spliceosome.

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7 January 2021

Cleavage of 5′ splice site and lariat formation are independent of 3′ splice site in yeast mRNA splicing

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7 January 2021

Fractionation and characterization of a yeast mRNA splicing extract

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7 January 2021

Role of the 3' splice site consensus sequence in mammalian pre-mRNA splicing

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7 January 2021

Yeast is unable to excise foreign intervening sequences from hybrid gene transcripts

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7 January 2021

Aberrant splicing of Drosophila alcohol dehydrogenase transcripts in Saccharomyces cerevisiae.

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7 January 2021

Alternative branch points are selected during splicing of a yeast pre-mRNA in mammalian and yeast extracts

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7 January 2021

Yeast contains small nuclear RNAs encoded by single copy genes

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7 January 2021

A U4-like small nuclear RNA is dispensable in yeast.

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7 January 2021

Small nuclear RNAs from Saccharomyces cerevisiae: unexpected diversity in abundance, size, and molecular complexity

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7 January 2021

A subset of yeast snRNA's contains functional binding sites for the highly conserved Sm antigen

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7 January 2021

Specific small nuclear RNAs are associated with yeast spliceosomes

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7 January 2021

Electrophoresis of ribonucleoproteins reveals an ordered assembly pathway of yeast splicing complexes

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7 January 2021

U2 RNA from yeast is unexpectedly large and contains homology to vertebrate U4, U5, and U6 small nuclear RNAs

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7 January 2021

Fission yeast Schizosaccharomyces pombe correctly excises a mammalian RNA transcript intervening sequence

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7 January 2021

Schizosaccharomyces pombe and Saccharomyces cerevisiae: a look at yeasts divided

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7 January 2021

Macromolecule Synthesis in Temperature-sensitive Mutants of Yeast

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7 January 2021

Identification of ten genes that control ribosome formation in yeast

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7 January 2021

The yeast RNA gene products are essential for mRNA splicing in vitro

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7 January 2021

Transcription termination and 3' processing: the end is in site!

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7 January 2021

Compensatory mutations suggest that base-pairing with a small nuclear RNA is required to form the 3' end of H3 messenger RNA

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7 January 2021

Accurate cleavage and polyadenylation of exogenous RNA substrate

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7 January 2021

A small nuclear ribonucleoprotein associates with the AAUAAA polyadenylation signal in vitro

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7 January 2021

Requirements for accurate and efficient mRNA 3' end cleavage and polyadenylation of a simian virus 40 early pre-RNA in vitro

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7 January 2021

Aspects of biochemical catalysis

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7 January 2021

Ribosomal activity of the 16 S.23 S RNA complex

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7 January 2021

Secondary structure of 16S ribosomal RNA.

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7 January 2021

A self-splicing RNA excises an intron lariat

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7 January 2021

Excised group II introns in yeast mitochondria are lariats and can be formed by self-splicing in vitro

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7 January 2021

Identifiers

DOI

10.1038/325673A0

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Dimensions Publication ID

12 September 2017

1027380581

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