Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer's disease-related pathogenesis (Q28833244)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27462420%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

author name string

Jin Cui

1

1 reference

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11 June 2020

Xiaoyin Wang

2

1 reference

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11 June 2020

Xiaohang Li

3

1 reference

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11 June 2020

Xin Wang

4

1 reference

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11 June 2020

Chenlu Zhang

5

1 reference

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11 June 2020

Wei Li

6

1 reference

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11 June 2020

Yangming Zhang

7

1 reference

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11 June 2020

Haifeng Gu

8

1 reference

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11 June 2020

Xin Xie

9

1 reference

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11 June 2020

Fajun Nan

10

1 reference

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11 June 2020

Gang Pei

12

1 reference

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11 June 2020

language of work or name

English

0 references

publication date

2015

0 references

2 references

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11 June 2020

volume

1

1 reference

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11 June 2020

page(s)

15021

1 reference

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Creative Commons Attribution 4.0 International

11 June 2020

copyright license

start time

18 August 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Antagonistic effects of beta-site amyloid precursor protein-cleaving enzymes 1 and 2 on beta-amyloid peptide production in cells

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Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

16 March 2017

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Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

16 March 2017

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

16 March 2017

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

16 March 2017

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

16 March 2017

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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

16 March 2017

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The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

16 March 2017

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

7 April 2017

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Targeting the β secretase BACE1 for Alzheimer's disease therapy

7 April 2017

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A fast growing spectrum of biological functions of γ-secretase in development and disease

3 June 2018

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Development and mechanism of γ-secretase modulators for Alzheimer's disease

3 June 2018

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Efficacy of SPI-1865, a novel gamma-secretase modulator, in multiple rodent models

3 June 2018

1 reference

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γ-Secretase modulator (GSM) photoaffinity probes reveal distinct allosteric binding sites on presenilin

3 June 2018

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Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa

3 June 2018

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Treatment strategies targeting amyloid β-protein

3 June 2018

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Development of clickable active site-directed photoaffinity probes for γ-secretase

3 June 2018

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Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease

3 June 2018

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Developing β-secretase inhibitors for treatment of Alzheimer's disease

3 June 2018

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Cleavage of neuregulin-1 by BACE1 or ADAM10 protein produces differential effects on myelination.

3 June 2018

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Amyloid precursor protein processing and Alzheimer's disease

3 June 2018

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When will Alzheimer's disease be cured? A pharmaceutical perspective

3 June 2018

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γ-Secretase modulators as potential disease modifying anti-Alzheimer's drugs

3 June 2018

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Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.

3 June 2018

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The secretases: enzymes with therapeutic potential in Alzheimer disease

3 June 2018

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Identification of beta-secretase (BACE1) substrates using quantitative proteomics

3 June 2018

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Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio

3 June 2018

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Modulation of gamma-secretase specificity using small molecule allosteric inhibitors

3 June 2018

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Substrate specificity of gamma-secretase and other intramembrane proteases

3 June 2018

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BACE1 regulates voltage-gated sodium channels and neuronal activity

3 June 2018

1 reference

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{gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE.

3 June 2018

1 reference

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A century of Alzheimer's disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860824

Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).

3 June 2018

1 reference

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The role of presenilin cofactors in the gamma-secretase complex

3 June 2018

1 reference

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Deciphering the genesis and fate of amyloid beta-protein yields novel therapies for Alzheimer disease

3 June 2018

1 reference

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Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860824

A sensitive and quantitative assay for measuring cleavage of presenilin substrates

3 June 2018

1 reference

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Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860824

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4860824

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

3 June 2018

1 reference

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Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains

3 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FCELLDISC.2015.21

A GPCR/secretase complex regulates beta- and gamma-secretase specificity for Abeta production and contributes to AD pathogenesis.

21 January 2018

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Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation.

21 January 2018

1 reference

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Presenilin-1 interacts directly with the beta-site amyloid protein precursor cleaving enzyme (BACE1).

21 January 2018

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https://api.crossref.org/works/10.1038%2FCELLDISC.2015.21

Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes

21 January 2018

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Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis.

21 January 2018

1 reference

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Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease

21 January 2018

1 reference

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Impaired spatial learning in the APPSwe + PSEN1DeltaE9 bigenic mouse model of Alzheimer's disease.

21 January 2018

1 reference

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Optimization of a natural product-based class of γ-secretase modulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCELLDISC.2015.21

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCELLDISC.2015.21

Partial Purification and Characterization of γ-Secretase from Post-mortem Human Brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCELLDISC.2015.21

BACE1 Suppression by RNA Interference in Primary Cortical Neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCELLDISC.2015.21

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCELLDISC.2015.21

Triterpenoids of Akebia quinata callus tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FCELLDISC.2015.21

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/CELLDISC.2015.21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27462420%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

11 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27462420%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

PubMed publication ID

27462420

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27462420%20AND%20SRC:MED&resulttype=core&format=json