In vitro RNA SELEX for the generation of chemically-optimized therapeutic RNA drugs (Q28828886)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26972786%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

title

In vitro RNA SELEX for the generation of chemically-optimized therapeutic RNA drugs (English)

1 reference

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10 March 2020

3

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10 March 2020

Shi-Jie Chen

4

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10 March 2020

author name string

Kevin T Urak

1

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10 March 2020

Sabrina Shore

2

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10 March 2020

Anton P McCaffrey

5

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10 March 2020

Paloma H Giangrande

6

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10 March 2020

language of work or name

English

0 references

publication date

10 March 2016

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10 March 2020

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10 March 2020

volume

103

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10 March 2020

page(s)

167-174

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Generation of Aptamers with an Expanded Chemical Repertoire

10 March 2020

cites work

1 reference

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Therapeutic aptamers: developmental potential as anticancer drugs

16 March 2017

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Challenges and opportunities for small molecule aptamer development

16 March 2017

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Sequencing technologies - the next generation

16 March 2017

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Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase

16 March 2017

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In vitro selection of RNA molecules that bind specific ligands

16 March 2017

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Analyzing HT-SELEX data with the Galaxy Project tools--A web based bioinformatics platform for biomedical research.

16 March 2017

1 reference

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Large scale analysis of the mutational landscape in HT-SELEX improves aptamer discovery

20 June 2018

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Targeted inhibition of prostate cancer metastases with an RNA aptamer to prostate-specific membrane antigen.

20 June 2018

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High-throughput binding characterization of RNA aptamer selections using a microplate-based multiplex microcolumn device

20 June 2018

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20 June 2018

Cell-SELEX Technology

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In vivo SELEX for Identification of Brain-penetrating Aptamers.

20 June 2018

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Therapeutic RNA aptamers in clinical trials

20 June 2018

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Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection

20 June 2018

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Screening mutant libraries of T7 RNA polymerase for candidates with increased acceptance of 2'-modified nucleotides

20 June 2018

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RNA aptamer-based functional ligands of the neurotrophin receptor, TrkB

20 June 2018

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Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers

20 June 2018

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Rational truncation of an RNA aptamer to prostate-specific membrane antigen using computational structural modeling.

20 June 2018

1 reference

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Nucleotide bias observed with a short SELEX RNA aptamer library

20 June 2018

1 reference

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Aptamer-targeted RNAi for HIV-1 therapy

20 June 2018

1 reference

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Quantitative selection of DNA aptamers through microfluidic selection and high-throughput sequencing

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921298

In vivo selection of tumor-targeting RNA motifs

20 June 2018

1 reference

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Continuous, real-time monitoring of cocaine in undiluted blood serum via a microfluidic, electrochemical aptamer-based sensor

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921298

Post-SELEX chemical optimization of a trypanosome-specific RNA aptamer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921298

Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice.

20 June 2018

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RNA aptamer-targeted inhibition of NF-kappa B suppresses non-small cell lung cancer resistance to doxorubicin.

20 June 2018

1 reference

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Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia.

20 June 2018

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SELEX--a (r)evolutionary method to generate high-affinity nucleic acid ligands

20 June 2018

1 reference

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2'-Deoxy purine, 2'-O-methyl pyrimidine (dRmY) aptamers as candidate therapeutics

20 June 2018

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Targeting the variable surface of African trypanosomes with variant surface glycoprotein-specific, serum-stable RNA aptamers.

20 June 2018

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A Y639F/H784A T7 RNA polymerase double mutant displays superior properties for synthesizing RNAs with non-canonical NTPs

20 June 2018

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RNA aptamers as reversible antagonists of coagulation factor IXa.

20 June 2018

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Systematic evolution of a DNA aptamer binding to rat brain tumor microvessels. selective targeting of endothelial regulatory protein pigpen

20 June 2018

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Novel approach to specific growth factor inhibition in vivo: antagonism of platelet-derived growth factor in glomerulonephritis by aptamers.

20 June 2018

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Oligonucleotide inhibitors of P-selectin-dependent neutrophil-platelet adhesion

20 June 2018

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2'-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain

20 June 2018

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Oligonucleotide inhibitors of human thrombin that bind distinct epitopes

20 June 2018

1 reference

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A mutant T7 RNA polymerase as a DNA polymerase.

20 June 2018

1 reference

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High-resolution molecular discrimination by RNA.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921298

Aptamers as therapeutics.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921298

Evolution of a T7 RNA polymerase variant that transcribes 2'-O-methyl RNA.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921298

In vitro selection of DNA aptamers to anthrax spores with electrochemiluminescence detection

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4921298

Aptamer Selection Technology and Recent Advances

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26972786

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.YMETH.2016.03.003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26972786%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26972786%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

1 reference