Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human β1 and α2 integrin (Q28730030)

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scientific article (publication date: 2012)

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English	Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human β1 and α2 integrin	scientific article (publication date: 2012)

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1 February 2020

Development of transgenic cloned pig models of skin inflammation by DNA transposon-directed ectopic expression of human β1 and α2 integrin (English)

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Nicklas Heine Staunstrup

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Maria Nascimento Primo

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Frederik Dagnæs-Hansen

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Henrik Callesen

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Jacob Giehm Mikkelsen

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Johannes Madsen

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Juan Li

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Ying Liu

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Peter M Kragh

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Rong Li

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Mette Schmidt

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Stig Purup

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Lars Svensson

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Thomas K Petersen

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Lars Bolund

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10 May 2012

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e36658

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Creative Commons Attribution 4.0 International

10 May 2012

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Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

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Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex

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Molecular cloning, occurrence, and expression of a novel partially secreted protein "psoriasin" that is highly up-regulated in psoriatic skin

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Integrins and signal transduction pathways: the road taken

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Induced keratinocyte hyper-proliferation in alpha2beta1 integrin transgenic mice results in systemic immune cell activation

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S100A7 (Psoriasin), highly expressed in ductal carcinoma in situ (DCIS), is regulated by IFN-gamma in mammary epithelial cells

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Piglets born from handmade cloning, an innovative cloning method without micromanipulation

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Mitogen- and stress-activated protein kinase 1 is critical for interleukin-1-induced, CREB-mediated, c-fos gene expression in keratinocytes.

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Sustained FVIII expression and phenotypic correction of hemophilia A in neonatal mice using an endothelial-targeted sleeping beauty transposon

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{beta}1 Integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation.

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A regulatory role for p38 delta MAPK in keratinocyte differentiation. Evidence for p38 delta-ERK1/2 complex formation

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Regulation of interleukin-1alpha expression by integrins and epidermal growth factor receptor in keratinocytes from a mouse model of inflammatory skin disease

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3 June 2018

Structure-function analysis of the inverted terminal repeats of the sleeping beauty transposon

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Mosaic gene expression in nuclear transfer-derived embryos and the production of cloned transgenic pigs from ear-derived fibroblasts

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Production of nuclear transfer-derived swine that express the enhanced green fluorescent protein.

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A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis

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Specific residues within the alpha 2 integrin subunit cytoplasmic domain regulate migration and cell cycle progression via distinct MAPK pathways

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Function and regulation of AP-1 subunits in skin physiology and pathology

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p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression

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alpha 2 integrin subunit cytoplasmic domain-dependent cellular migration requires p38 MAPK.

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Cloned pigs produced by nuclear transfer from adult somatic cells

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Integrin alpha 2 beta 1-dependent EGF receptor activation at cell-cell contact sites.

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beta1 integrins regulate keratinocyte adhesion and differentiation by distinct mechanisms

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Integrin alpha2beta1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the alpha2 cytoplasmic tail

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3 June 2018

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Effect of in vivo interleukin-1 on adhesion molecule expression in normal human skin

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3 June 2018

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3 June 2018

Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis

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21 January 2018

Integrin expression by human epidermal keratinocytes can be modulated by interferon-gamma, transforming growth factor-beta, tumor necrosis factor-alpha, and culture on a dermal equivalent

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21 January 2018

Cloning of mice to six generations.

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21 January 2018

Cloning of male mice from adult tail-tip cells.

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21 January 2018

Eight calves cloned from somatic cells of a single adult.

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21 January 2018

Production of cloned pigs from in vitro systems.

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21 January 2018

Pig cloning by microinjection of fetal fibroblast nuclei.

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21 January 2018

Production of transgenic porcine blastocysts by hand-made cloning

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21 January 2018

Production of nuclear transfer-derived piglets using porcine fetal fibroblasts transfected with the enhanced green fluorescent protein

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21 January 2018

A novel method for the production of transgenic cloned pigs: electroporation-mediated gene transfer to non-cultured cells and subsequent selection with puromycin.

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21 January 2018

Helper-Independent Sleeping Beauty transposon-transposase vectors for efficient nonviral gene delivery and persistent gene expression in vivo

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21 January 2018

Efficient gene delivery and gene expression in zebrafish using the Sleeping Beauty transposon.

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21 January 2018

Generation of trangenic Xenopus laevis using the Sleeping Beauty transposon system.

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21 January 2018

PKCepsilon is a permissive link in integrin-dependent IFN-gamma signalling that facilitates JAK phosphorylation of STAT1.

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21 January 2018

The antimicrobial protein psoriasin (S100A7) is upregulated in atopic dermatitis and after experimental skin barrier disruption.

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21 January 2018

Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression

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21 January 2018

Influence of beta1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: alpha3beta1, but not alpha2beta1, suppresses malignant conversion

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27 November 2018

CD56brightCD16(-) NK cells accumulate in psoriatic skin in response to CXCL10 and CCL5 and exacerbate skin inflammation

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12 December 2020

based on heuristic

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Pregnancies and piglets from large white sow recipients after two transfer methods of cloned and transgenic embryos of different pig breeds

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the c-fos enhancer by the erk MAP kinase pathway through two sequence elements: the c-fos AP-1 and p62TCF sites

1 reference

https://pubmed.ncbi.nlm.nih.gov/22590584

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2

1 reference

https://pubmed.ncbi.nlm.nih.gov/22590584

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skin permeability in vivo: comparison in rat, rabbit, pig and man

1 reference

https://pubmed.ncbi.nlm.nih.gov/22590584

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cells involved in psoriasis vulgaris belong to the Th1 subset

1 reference

https://pubmed.ncbi.nlm.nih.gov/22590584

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0036658

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22590584%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

2012PLoSO...736658S

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22590584%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22590584%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

ResearchGate publication ID

0 references

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