A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters (Q28609428)

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English	A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters	scientific journal article

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scholarly article

1 reference

3 February 2017

A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters (English)

2 references

3 February 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740799&resulttype=core&format=json

12 May 2020

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author name string

David Robertson

2

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3 February 2017

Europe PubMed Central

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12 May 2020

Maureen K Hahn

1

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12 May 2020

Randy D Blakely

3

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12 May 2020

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publication date

1 June 2003

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3 February 2017

Journal of Neuroscience

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3 February 2017

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12 May 2020

23

2 references

3 February 2017

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12 May 2020

4470-4478

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12 May 2020

11

2 references

3 February 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740799&resulttype=core&format=json

12 May 2020

Abnormal norepinephrine clearance and adrenergic receptor sensitivity in idiopathic orthostatic intolerance

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dominant negative isoform of rat norepinephrine transporter produced by alternative RNA splicing

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https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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Characteristics of drug interactions with recombinant biogenic amine transporters expressed in the same cell type

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https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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The reactivity of the gamma-aminobutyric acid transporter GAT-1 toward sulfhydryl reagents is conformationally sensitive. Identification of a major target residue

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effects

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https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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Studies on the acute and chronic effects of reboxetine on extracellular noradrenaline and other monoamines in the rat brain

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https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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The role of external loop regions in serotonin transport. Loop scanning mutagenesis of the serotonin transporter external domain

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https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency

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https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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Oligomerization of serotonin transporter and its functional consequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter

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https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

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Mice lacking the norepinephrine transporter are supersensitive to psychostimulants

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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Pentameric assembly of a neuronal glutamate transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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A trafficking checkpoint controls GABA(B) receptor heterodimerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

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Oligomerization of the human serotonin transporter and of the rat GABA transporter 1 visualized by fluorescence resonance energy transfer microscopy in living cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

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Interactions of tryptamine derivatives with serotonin transporter species variants implicate transmembrane domain I in substrate recognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

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The neuronal norepinephrine transporter in experimental heart failure: evidence for a posttranscriptional downregulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

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Mutation K448E in the external loop 5 of rat GABA transporter rGAT1 induces pH sensitivity and alters substrate interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

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Physiological genomics of antidepressant targets: keeping the periphery in mind.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

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Serotonin transporter function and pharmacology are sensitive to expression level: evidence for an endogenous regulatory factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

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Pharmacological properties of the naturally occurring Ala(457)Pro variant of the human norepinephrine transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determinants within the C-terminus of the human norepinephrine transporter dictate transporter trafficking, stability, and activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

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Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

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Mutations within an intramembrane leucine heptad repeat disrupt oligomer formation of the rat GABA transporter 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

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Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

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A regulated interaction of syntaxin 1A with the antidepressant-sensitive norepinephrine transporter establishes catecholamine clearance capacity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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Myocardial beta-adrenergic desensitization and neuronal norepinephrine uptake function in idiopathic dilated cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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THE UPTAKE OF NORADRENALINE BY THE ISOLATED PERFUSED RAT HEART.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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3Hnisoxetine: a radioligand for quantitation of norepinephrine uptake sites by autoradiography or by homogenate binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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Catecholamine release and arrhythmias in acute myocardial ischaemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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Cocaine inhibition of ligand binding at dopamine, norepinephrine and serotonin transporters: a structure-activity study

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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The extent of neuronal re-uptake of 3H-noradrenaline in isolated vasa deferentia and atria of the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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The catecholamine hypothesis of affective disorders: a review of supporting evidence

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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Nucleus locus ceruleus: new evidence of anatomical and physiological specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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Release of endogenous catecholamines in the ischemic myocardium of the rat. Part A: Locally mediated release.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

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The antiarrhythmic action of amitriptyline on arrhythmias associated with myocardial infarction in dogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Norepinephrine kinetics in essential hypertension. Defective neuronal uptake of norepinephrine in some patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sodium-dependent norepinephrine-induced currents in norepinephrine-transporter-transfected HEK-293 cells blocked by cocaine and antidepressants

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for reduction of norepinephrine uptake sites in the failing human heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-type-specific expression of catecholamine transporters in the rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo dynamics of norepinephrine release-reuptake in multiple terminal field regions of rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human norepinephrine transporter. Biosynthetic studies using a site-directed polyclonal antibody

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sodium- and chloride-dependent, cocaine-sensitive, high-affinity binding of nisoxetine to the human placental norepinephrine transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chromosomal mapping of the human gene for the tricyclic antidepressant-sensitive noradrenaline transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

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Reduced myocardial 123I-metaiodobenzylguanidine uptake in newly diagnosed IDDM patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

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Inability to N-glycosylate the human norepinephrine transporter reduces protein stability, surface trafficking, and transport activity but not ligand recognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural domains of catecholamine transporter chimeras involved in selective inhibition by antidepressants and psychomotor stimulants

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

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Polarized expression of the antidepressant-sensitive serotonin transporter in epinephrine-synthesizing chromaffin cells of the rat adrenal gland

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The third transmembrane domain of the serotonin transporter contains residues associated with substrate and cocaine binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of noradrenaline in depression: a review

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological profile of antidepressants and related compounds at human monoamine transporters

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible existence of quaternary structure in the high-affinity serotonin transport complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino acid residues that control pH modulation of transport-associated current in mammalian serotonin transporters.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

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The family of Na+/Cl- neurotransmitter transporters.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

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Acute regulation of norepinephrine transport: I. protein kinase C-linked muscarinic receptors influence transport capacity and transporter density in SK-N-SH cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute regulation of norepinephrine transport: II. PKC-modulated surface expression of human norepinephrine transporter proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

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Chamber-specific alterations of norepinephrine uptake sites in cardiac hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/12805287

12 December 2020

based on heuristic

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Identifiers

10.1523/JNEUROSCI.23-11-04470.2003

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740799&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740799&resulttype=core&format=json

12 May 2020

2 references

3 February 2017

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6740799&resulttype=core&format=json

12 May 2020

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