Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells (Q28595100)

Shivalingappa K. Swamynathan

GOA release 2020-03-11

4

Ruth Ashery-Padan

1 reference

1 February 2017

object named as

Shivalingappa K. Swamynathan

1

1 reference

ORCID Public Data File 2021

author name string

Jonathan P. Katz

2

1 reference

1 February 2017

Klaus H. Kaestner

3

1 reference

1 February 2017

Mary A. Crawford

5

1 reference

1 February 2017

Joram Piatigorsky

Molecular and Cellular Biology

6

1 reference

1 February 2017

language of work or name

English

0 references

publication date

1 January 2007

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1 February 2017

1 reference

1 February 2017

27

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1 February 2017

182–194

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1 February 2017

1

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1 February 2017

A role for chromosomal protein HMGN1 in corneal maturation

1 reference

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Molecular basis for keratoconus: lack of TrkA expression and its transcriptional repression by Sp3

17 March 2017

1 reference

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Current molecular understanding of Axenfeld-Rieger syndrome

17 March 2017

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Targeted deletion of AP-2alpha leads to disruption in corneal epithelial cell integrity and defects in the corneal stroma

17 March 2017

1 reference

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Developmentally regulated expression of KLF6 in the mouse cornea and lens

17 March 2017

1 reference

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Sonic hedgehog expression and role in healing corneal epithelium

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Neurturin-Deficient Mice Develop Dry Eye and Keratoconjunctivitis Sicca

17 March 2017

1 reference

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Aquaporin deletion in mice reduces corneal water permeability and delays restoration of transparency after swelling

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Klf4 is a transcription factor required for establishing the barrier function of the skin

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Isolation and chromosomal localization of a cornea-specific human keratin 12 gene and detection of four mutations in Meesmann corneal epithelial dystrophy

17 March 2017

1 reference

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Mutations in cornea-specific keratin K3 or K12 genes cause Meesmann's corneal dystrophy

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Keratin 12-deficient mice have fragile corneal epithelia

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

A gene for a novel zinc-finger protein expressed in differentiated epithelial cells and transiently in certain mesenchymal cells

17 March 2017

1 reference

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Identification and characterization of a gene encoding a gut-enriched Krüppel-like factor expressed during growth arrest

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

The balance between corneal transparency and edema: the Proctor Lecture

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

KLF4, p21 and context-dependent opposing forces in cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Inherited corneal disease: the evolving molecular, genetic and imaging revolution

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Drastic down-regulation of Krüppel-like factor 4 expression is critical in human gastric cancer development and progression

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Gene expression profile studies of human keratoconus cornea for NEIBank: a novel cornea-expressed gene and the absence of transcripts for aquaporin 5.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Cell and tissue specific expression of human Krüppel-like transcription factors in human ocular surface.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Corneal development associated with eyelid opening.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Ocular surface in Zn-deficient rats

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Postnatal gene expression in the normal mouse cornea by SAGE.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Preferential transcription of rabbit Aldh1a1 in the cornea: implication of hypoxia-related pathways

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Control of mucin production by ocular surface epithelial cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Talking about a Revolution

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Transcription Factors Pax6 and AP-2alpha Interact To Coordinate Corneal Epithelial Repair by Controlling Expression of Matrix Metalloproteinase Gelatinase B

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Transparency, swelling and scarring in the corneal stroma.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Changes in the Refractive Index of the Stroma and Its Extrafibrillar Matrix When the Cornea Swells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Ectopic expression of Kruppel like factor 4 (Klf4) accelerates formation of the epidermal permeability barrier

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

The molecular genetics of the corneal dystrophies--current status

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Positive influence of AP-2alpha transcription factor on cadherin gene expression and differentiation of the ocular surface

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Role of aquaporin water channels in eye function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Centripetal movement of corneal epithelial cells in the normal adult mouse

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Regulation of mucin and fluid secretion by conjunctival epithelial cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Regulation of corneal keratin-12 gene expression by the human Krüppel-like transcription factor 6.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Significance of mucin on the ocular surface

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Molecular mechanisms of water transport in the eye.

29 September 2017

1 reference

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Early eye development in vertebrates

29 September 2017

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Krüppel-like factors: three fingers in many pies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

The biology of the mammalian Krüppel-like family of transcription factors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Pax-6 expression and activity are induced in the reepithelializing cornea and control activity of the transcriptional promoter for matrix metalloproteinase gelatinase B.

29 September 2017

1 reference

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Expression patterns of retinoblastoma and E2F family proteins during corneal development

29 September 2017

1 reference

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Corneal epithelium-specific mouse keratin K12 promoter.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Identification of the DNA sequence that interacts with the gut-enriched Krüppel-like factor

29 September 2017

1 reference

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Cell lineage and the differentiation of corneal epithelial cells

29 September 2017

1 reference

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Cornea-specific expression of K12 keratin during mouse development.

29 September 2017

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On the evaluation of the corneal epithelial surface by scanning electron microscopy

29 September 2017

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Relative proliferative rates of limbal and corneal epithelia. Implications of corneal epithelial migration, circadian rhythm, and suprabasally located DNA-synthesizing keratinocytes

29 September 2017

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29 September 2017

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An involucrin promoter AP1 transcription factor binding site is required for expression of involucrin in the corneal epithelium in vivo

29 September 2017

1 reference

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3 June 2018

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3 June 2018

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Synchronization of the G1/S transition in response to corneal debridement

3 June 2018

1 reference

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An SV40-immortalized human corneal epithelial cell line and its characterization

3 June 2018

1 reference

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Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Kruppel-like factor 6 (KLF6) affects the promoter activity of the alpha1-proteinase inhibitor gene.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Expression of keratin 12 and maturation of corneal epithelium during development and postnatal growth

27 November 2018

1 reference

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Developmentally regulated expression of Sp1 in the mouse cornea.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Dominant mutations of Col4a1 result in basement membrane defects which lead to anterior segment dysgenesis and glomerulopathy

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Involucrin expression in the corneal epithelium: an essential role for Sp1 transcription factors

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Spontaneous ocular surface inflammation and goblet cell disappearance in I kappa B zeta gene-disrupted mice.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Dynamic expression of Krüppel-like factor 4 (Klf4), a target of transcription factor AP-2alpha during murine mid-embryogenesis.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Requirement for Pax6 in corneal morphogenesis: a role in adhesion

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1800665

Cis-regulatory elements of the mouse Krt1.12 gene.

27 November 2018

1 reference

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Quantification of MUC5AC protein in human tears.

27 November 2018

1 reference

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Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sjögren syndrome

27 November 2018

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12 December 2020

Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach

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12 December 2020

The X, Y, Z hypothesis of corneal epithelial maintenance

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12 December 2020

Conjunctival goblet cell densities in ocular surface disease

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12 December 2020

Goblet cell density in thermal and chemical injuries

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12 December 2020