Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation (Q28594159)

Journal of Biological Chemistry

GOA release 2020-03-11

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Valeria Petronilli

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Paolo Bernardi

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Paolo Bernardi

series ordinal

4

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Emy Basso

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1

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Emy Basso

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31 January 2017

Michael A. Forte

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31 January 2017

language of work or name

English

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publication date

26 September 2008

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31 January 2017

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31 January 2017

283

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39

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31 January 2017

26307–26311

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31 January 2017

Cyclosporin A corrects mitochondrial dysfunction and muscle apoptosis in patients with collagen VI myopathies

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Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

17 March 2017

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Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

17 March 2017

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Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

17 March 2017

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The Ca2+-induced membrane transition in mitochondria. II. Nature of the Ca2+ trigger site

17 March 2017

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Mitochondrial membrane permeabilization in cell death

17 March 2017

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The mitochondrial phosphate carrier interacts with cyclophilin D and may play a key role in the permeability transition

7 April 2017

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Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death

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Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis

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Mitochondrial dysfunction in the pathogenesis of Ullrich congenital muscular dystrophy and prospective therapy with cyclosporins

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The mitochondrial permeability transition from in vitro artifact to disease target

29 September 2017

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Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.

29 September 2017

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A large, voltage-dependent channel, isolated from mitochondria by water-free chloroform extraction.

29 September 2017

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29 September 2017

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The voltage-dependent anion channel is the target for a new class of inhibitors of the mitochondrial permeability transition pore

29 September 2017

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Regulation of the mitochondrial permeability transition pore by ubiquinone analogs. A progress report

29 September 2017

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Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adeni

29 September 2017

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Relationship between configuration, function, and permeability in calcium-treated mitochondria

29 September 2017

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The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria

29 September 2017

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Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel

29 September 2017

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The Mechanism of Ion Translocation in Mitochondria. 4. Coupling of K+ Efflux with Ca2+ Uptake

3 June 2018

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Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress

3 June 2018

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Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties

3 June 2018

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The phosphate requirement for Ca2+-uptake by heart and liver mitochondria

3 June 2018

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The relationship between free and total calcium concentrations in the matrix of liver and brain mitochondria.

3 June 2018

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Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by matrix pH. Evidence that the pore open-closed probability is regulated by reversible histidine protonation.

21 January 2018

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Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, and cyclosporin A-sensitive channel.

21 January 2018

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Metabolic network control of oxidative phosphorylation: multiple roles of inorganic phosphate

21 January 2018

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Three classes of ubiquinone analogs regulate the mitochondrial permeability transition pore through a common site

21 January 2018

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Effect of cyclosporine on reperfusion injury in acute myocardial infarction

21 January 2018

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The Ca2+-induced membrane transition in mitochondria

21 January 2018

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A Ubiquinone-binding Site Regulates the Mitochondrial Permeability Transition Pore

21 January 2018

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On the nature of Pi -induced, Mg2+ -prevented Ca2+ release in rat liver mitochondria

21 January 2018

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Mitochondrial dysfunction and apoptosis in myopathic mice with collagen VI deficiency.

21 January 2018

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Glucagon effects on the membrane potential and calcium uptake rate of rat liver mitochondria

27 November 2018

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12 December 2020

Calcium transport in mitochondria

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12 December 2020

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

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12 December 2020

Action of cyclosporine on mitochondrial calcium fluxes

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12 December 2020

Intracellular pH and inorganic phosphate content of heart in vivo: a 31P-NMR study

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12 December 2020

CATION AND ANION BALANCE DURING ACTIVE ACCUMULATION OF CA++ AND MG++ BY ISOLATED MITOCHONDRIA

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12 December 2020

Ca ion uptake by rat kidney mitochondria and its dependence on respiration and phosphorylation

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12 December 2020

Respiration-dependent accumulation of inorganic phosphate and Ca ions by rat liver mitochondria

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12 December 2020

Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations

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12 December 2020

H+/site ratio and steady state distribution of divalent cations in mitochondria

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12 December 2020